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research
Head and neck squamous cell carcinoma of unknown primary: Neck dissection and radiotherapy or definitive radiotherapy
Authors
Ang
Armas
+37 more
Aslani
Bernier
Braud
Chaturvedi
Christiansen
Colletier
Coster
Dagan
Davidson
Denis
El-Mofty
Erkal
Forastiere
Frank
Freeman
Grau
Iganej
Lee
Macdonald
Machtay
Mack
Maxwell
Mendenhall
Miller
Nguyen
Nieder
Park
Patel
Perkins
Punwaney
Reddy
Strojan
Tribius
Wallace
Walter
Weir
Zengel
Publication date
1 November 2014
Publisher
'Wiley'
Doi
Cite
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on
PubMed
Abstract
Background Management of head and neck carcinoma from unknown primary (HNCUP) remains controversial, with neck dissection and radiotherapy (RT) or definitive RT both commonly used. The purpose of this study was to characterize HNCUP and retrospectively compare outcomes for patients treated with neck dissection + RT versus definitive RT. Methods From 1994 to 2009, 41 patients with HNCUP underwent either neck dissection + RT ( n = 22) or definitive RT ± concurrent chemotherapy ( n = 19) at our institution. Treatment outcomes were compared using Kaplan–Meier methods and log‐rank test. Results There were no differences between patients treated with neck dissection + RT and definitive RT in overall survival (OS), progression‐free survival (PFS), locoregional relapse‐free survival (LRFS), freedom from locoregional failure (FFLRG), or freedom from distant failure (FFDF). Among 17 patients who underwent neck dissection + RT for whom human papillomavirus (HPV) status could be determined, HPV(+) patients trended toward improved OS ( p = .06) and PFS ( p = .15). Conclusion Neck dissection and postoperative RT resulted in similar outcomes as definitive RT. The prognostic implications of HPV(+) nodes in HNCUP are similar to those in oropharyngeal primary cancers. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1589–1595, 2014Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109313/1/hed23479.pd
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info:doi/10.1002%2Fhed.23479
Last time updated on 02/01/2020
Deep Blue Documents at the University of Michigan
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oai:deepblue.lib.umich.edu:202...
Last time updated on 20/12/2016