Incidence and serotype distribution of disease in Malawi are similar to those reported from industrialized countries, but case-fatality rate is high

Amos J. Phiri

Andrews

Baker

Berg

Berkley

Bomela

Dahl

Dawodu

De Mouy

English

French

Goldenberg

Guttormsen

Harrison

Heath

Isaacs

Kalliola

Kasper

Katherine J. Gray

Laving

Lyytikainen

Madhi

Milledge

Moyo

Mwapasa

Nathoo

Neil French

Persson

Sally L. Bennett

Schrag

Schuchat

Shet

Stephen M. Graham

Stoll

Suara

Taha

Vandelaer

Weisner

Emerging Infectious Diseases

PubMed

Group B streptococci (GBS) are a recently identified cause of neonatal sepsis in Malawi. In Queen Elizabeth Central Hospital, Blantyre, Malawi, during May 2004–June 2005, GBS were isolated from routine blood and cerebrospinal fluid cultures from 57 infants. The incidence of early (EOD) and late onset (LOD) invasive GBS disease was 0.92 and 0.89 cases per 1,000 live births, respectively. Sepsis (52%) was the most common manifestation of EOD; meningitis (43%) and sepsis (36%) were the principal manifestations of LOD. The case-fatality rate was 33% overall (38% EOD, 29% LOD). Serotypes Ia and III were responsible for 77% of disease. All isolates were susceptible to penicillin, but 21% were resistant to erythromycin. The rate and manifestations of neonatal GBS disease in Malawi are similar to those in industrialized countries, but the case-fatality rate is higher than in industrialized countries. Effective locally relevant prevention strategies are needed

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Invasive Group B Streptococcal Infection in Infants, Malawi

Group B streptococci (GBS) are a recently identified cause of neonatal sepsis in Malawi. In Queen Elizabeth Central Hospital, Blantyre, Malawi, during May 2004-June 2005, GBS were isolated from routine blood and cerebrospinal fluid cultures from 57 infants. The incidence of early (EOD) and late onset (LOD) invasive GBS disease was 0.92 and 0.89 cases per 1,000 live births, respectively. Sepsis (52%) was the most common manifestation of EOD; meningitis (43%) and sepsis (36%) were the principal manifestations of LOD. The case-fatality rate was 33% overall (38% EOD, 29% LOD). Serotypes Ia and III were responsible for 77% of disease. All isolates were susceptible to penicillin, but 21% were resistant to erythromycin. The rate and manifestations of neonatal GBS disease in Malawi are similar to those in industrialized countries, but the case-fatality rate is higher than in industrialized countries. Effective locally relevant prevention strategies are needed

Gray, Katherine J

Bennett, Sally L

French, Neil

Phiri, Amos J

Graham, Stephen M

LSHTM Research Online

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Invasive Group B Streptococcal Infection in Infants, Malawi

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