Horizontal gene transfer and clonal expansion contribute substantially to the dissemination of resistant strain

Altschul

Blahna

Boyd

Butaye

Carattoli

David L. Paterson

Davis

Falush

Guerra

Hald

Harbottle

Jane W. Marsh

Kidgell

Lee H. Harrison

Leverstein-van Hall

Levesque

Maguire

Mary G. Krauland

Mead

Mulvey

Ozgumus

O’Mahony

Rahn

Roumagnac

Threlfall

Toleman

Torpdahl

Voetsch

Emerging Infectious Diseases

English

PubMed

Crossref

Integron-mediated Multidrug Resistance in a Global Collection of Nontyphoidal
                    Salmonella

Salmonella enterica bacteria have become increasingly resistant to antimicrobial agents, partly as a result of genes carried on integrons. Clonal expansion and horizontal gene transfer may contribute to the spread of antimicrobial drug-resistance integrons in these organisms. We investigated this resistance and integron carriage among 90 isolates with the ACSSuT phenotype (resistance to ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline) in a global collection of S. enterica isolates. Four integrons, dfrA12/orfF/aadA2, dfrA1/aadA1, dfrA7, and arr2/blaOXA30/cmlA5/aadA2, were found in genetically unrelated isolates from 8 countries on 4 continents, which supports a role for horizontal gene transfer in the global dissemination of S. enterica multidrug resistance. Serovar Typhimurium isolates containing identical integrons with the gene cassettes blaPSE1 and aadA2 were found in 4 countries on 3 continents, which supports the role of clonal expansion. This study demonstrates that clonal expansion and horizontal gene transfer contribute to the global dissemination of antimicrobial drug resistance in S. enterica

Krauland, Mary G.

Marsh, Jane W.

Paterson, David L.

Harrison, Lee H.

University of Queensland eSpace

Integron-mediated multidrug resistance in a global collection of nontyphoidal salmonella enterica isolates

Ampliﬁ cation of an invA gene sequence of Salmonella typhimurium by polymerase chain reaction as a speciﬁ c method of detection of Salmonella. Mol Cell Probes.

Antimicrobial resistance in nontyphoidal salmonella from food sources in Colombia: evidence for an unusual plasmid-localized class 1 integron in serotypes Typhimurium and Anatum. Microb Drug Resist.

Basic local alignment search tool.

Characterization of variant Salmonella genomic island 1 multidrug resistance regions from serovars Typhimurium DT104 and Agona. Antimicrob Agents Chemother.

Comparison of multilocus sequence typing, pulsed-ﬁ eld gel electrophoresis, and antimicrobial susceptibility typing for characterization of Salmonella enterica serotype Newport isolates.

Disease Control and Prevention. National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS): human isolates ﬁ nal report,

Epidemic Salmonella typhimurium DT 104—a truly international multiresistant clone.

Evidence of extensive interspecies transfer of integronmediated antimicrobial resistance genes among multidrug-resistant Enterobacteriaceae in a clinical setting. J Infect Dis.

Expanding drug resistance through integron acquisition by IncFI plasmids of Salmonella enterica Typhimurium. Emerg Infect Dis.

Food-related illness and death in the United States. Emerg Infect Dis.

FoodNet estimate of the burden of illness caused by nontyphoidal Salmonella infections in the United States. Clin Infect Dis.

Genotypic characterization of Salmonella by multilocus sequence typing, pulsed-ﬁ eld gel electrophoresis and ampliﬁ ed fragment length polymorphism.

Global emergence of trimethoprim/sulfamethoxazole resistance in Stenotrophomonas maltophilia mediated by acquisition of sul genes. Emerg Infect Dis.

Importance of integrons in the diffusion of resistance. Vet Res.

Lo Fo Wong DM, Aarestrup FM. The attribution of human infections with antimicrobial resistant Salmonella bacteria in Denmark to sources of animal origin. Foodborne Pathog Dis.

Mismatch induced speciation in Salmonella: model and data. Philos Trans R Soc Lond B Biol Sci.

Molecular characterization of antibiotic resistant Escherichia coli strains isolated from tap and spring waters in a coastal region in Turkey.

Multidrug resistance is mediated by large plasmids carrying a class 1 integron in the emergent Salmonella enterica serotype [4,5,12:i:-]. Antimicrob Agents Chemother.

Multiresistant clones of Salmonella enterica: the importance of dissemination.

Organization. World Health Organization antimicrobial resistance fact sheet no.

Partial characterization of a genomic island associated with the multidrug resistance region of Salmonella enterica Typhimurium DT104. FEMS Microbiol Lett.

PCR mapping of integrons reveals several novel combinations of resistance genes. Antimicrob Agents Chemother.

Plasmid-mediated antimicrobial resistance in Salmonella enterica.

Rapid screening technique for class 1 integrons in Enterobacteriaceae and nonfermenting gram-negative bacteria and its use in molecular epidemiology. Antimicrob Agents Chemother.

Salmonella typhi, the causative agent of typhoid fever, is approximately 50,000 years old. Infect Genet Evol.

The clonal spread of multidrug-resistant non-typhi Salmonella serotypes. Microbes Infect.

The genetics of Salmonella genomic island 1. Microbes Infect.

The role of horizontal gene transfer in the spread of trimethoprim-sulfamethoxazole resistance among uropathogenic Escherichia coli in Europe and

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2666292

Integron-mediated Multidrug Resistance in a Global Collection of Nontyphoidal Salmonella enterica Isolates

Integron-mediated Multidrug Resistance in a Global Collection of Nontyphoidal Salmonella enterica Isolates

Abstract

Similar works

Full text

Available Versions

Crossref

University of Queensland eSpace