One-sentence summary for table of contents: Different genotypes and subtypes are linked to different clinical manifestations

Ajjampur

Alves

Bern

Bushen

Cama

Caryn Bern

Charles R. Sterling

Flanigan

Gatei

Hung

Hunter

Jacqueline Roberts

Leav

Lihua Xiao

Lilia Cabrera

Mata

Matos

Meamar

Okhuysen

Peng

Priest

Raccurt

Robert H. Gilman

Sallon

Samie

Simango

Sopwith

Spano

Sturbaum

Sulaiman

Tumwine

Tzipori

Vitaliano A. Cama

Xiao

Ynes Ortega

Yoder

Emerging Infectious Diseases

English

PubMed

Crossref

Cryptosporidium

To determine whether clinical manifestations are associated with genotypes or subtypes of Cryptosporidium spp., we studied a 4-year longitudinal birth cohort of 533 children in Peru. A total of 156 infection episodes were found in 109 children. Data from first infections showed that C. hominis was associated with diarrhea, nausea, vomiting, general malaise, and increased oocyst shedding intensity and duration. In contrast, C. parvum, C. meleagridis, C. canis, and C. felis were associated with diarrhea only. C. hominis subtype families were identified (Ia, Ib, Id, and Ie); all were associated with diarrhea. Ib was also associated with nausea, vomiting, and general malaise. All C. parvum specimens belonged to subtype family IIc. Analysis of risk factors did not show associations with specific Cryptosporidium spp. genotypes or subtypes. These findings strongly suggest that Cryptosporidium spp. and subtypes are linked to different clinical manifestations in children

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Cryptosporidium Species and Subtypes and Clinical Manifestations in Children, Peru

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Cryptosporidium Species and Subtypes and Clinical Manifestations in Children, Peru

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