Homocitrato Molybdates and their Homologues

Abstract

固氮酶是某些微生物在常温常压下固氮成氨的催化剂,其催化作用机理和化学模拟一直是国际上长期致力研究的对象。最新的钼铁蛋白单晶高分辨X光衍射分析表明,铁钼辅基的结构为MoFe7S9N(S-cys)(N-His)(homocit)。其中,Mo原子处于一端的角落位置上,并和3个μ3-硫配体、一个组氨酸和一个高柠檬酸配位,形成八面体的络合物。高柠檬酸以-烷氧基和-羧基直接同钼形成双齿配位。生物活性研究表明,含有高柠檬酸的固氮酶的固氮活性比其它羟基羧酸突变种的固氮酶活性强。但在固氮酶的固氮过程中,高柠檬酸发挥什么样的作用一直悬而未决。另外,过氧钼、钨配合物显示了独特的催化活...Nitrogenase catalyzes the reduction of dinitrogen to ammonia in the process of biological nitrogen fixation. In the past few decades, its catalytic mechanism and chemical simulation have been widely studied. The recent high resolution (1.16 Å) X-ray structural analysis of the MoFe protein of nitrogenase reveals the FeMo-co (iron molybdenum cofactor) as a cage structure, MoFe7S9N(S-cys)(N-His...学位:理学博士院系专业:化学化工学院化学系_物理化学(含化学物理)学号:B20012502

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