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表皮生长因子受体抑制剂对外源锌离子致大鼠急性呼吸道炎症的影响
Authors
关文池
吴卫东
+6 more
吴逸明
李冰
梁宁
燕贞
王威
贾陈志
Publication date
20 May 2011
Publisher
Abstract
目的:探讨表皮生长因子受体(EGFR)抑制剂对外源锌离子致大鼠呼吸道急性炎症的影响。方法:将100μmol/L硫酸锌溶液经气管灌注大鼠肺部复制动物炎症模型,于灌注后4h、8h和24h处死大鼠,以PBS为对照,分别测定支气管肺泡灌洗液(BALF)中白细胞计数、总蛋白、白细胞介素8(IL-8)以及乳酸脱氢酶(LDH)的含量,以选择炎症最明显的时间点。进一步用二甲基亚砜(DMSO)和EGFR抑制剂PD153035预灌注大鼠,观察其对硫酸锌溶液所致呼吸道炎症的影响。结果:不同灌注液作用后大鼠白细胞计数(F=12.149,P=0.002)和IL-8(F=48.680,P<0.001)等炎症反应指标不同,不同时间点白细胞计数(F=29.569,P<0.001)和IL-8(F=59.778,P<0.001)等炎症反应指标也不同,硫酸锌灌注后8h为炎症反应最强的时间。不同预灌注液作用后大鼠白细胞计数(F=37.872,P<0.001)和IL-8(F=24.347,P<0.001)等炎症反应指标不同,PD153035能抑制炎症反应的强度。结论:EGFR抑制剂能有效抑制外源锌离子所致大鼠呼吸道急性炎症
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Last time updated on 16/06/2016