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戊型肝炎重组蛋白聚乳酸羟基乙酸微球疫苗的研究
Authors
伍小路
傅顺
+6 more
吴婷
吴飞
夏宁邵
耿燕
袁伟恩
金拓
Publication date
1 July 2008
Publisher
Abstract
目的:研究戊型肝炎重组蛋白(NE2)聚乳酸羟基乙酸(PLGA)微球疫苗诱导免疫应答的情况。方法:复乳法制备微球,考察粒径分布等特性。通过间接ELISA法检测其诱导BALB/c小鼠体内IgG、IgG2a和IgG1水平,并通过IFN--ELISPOT方法检测其诱导BALB/c小鼠体内抗原特异性免疫应答情况。结果:微球的平均粒径为7.1 m。注射小鼠6周后(第4周加强免疫1次),微球疫苗诱导产生的抗戊型肝炎病毒IgG抗体水平较同剂量铝佐剂组明显升高(间接ELISA:OD450/620 10.09 vs.5.32)。IgG2a抗体量略高于铝佐剂组,OD450/620分别为0.17、0.04。IgG1抗体量明显高于铝佐剂组,OD450/620分别为20.48、15.00。IFN--ELISPOT结果显示,微球疫苗能很好的诱导NE2或P34肽抗原特异性免疫应答。结论:戊型肝炎重组蛋白聚乳酸羟基乙酸微球作为疫苗输送体系能明显的提高抗原的免疫原性,有很好的应用前景
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Last time updated on 16/06/2016