Funding: This study was supported by Medtronic Europe Sàrl through an independent research grant. Medtronic was not involved in the collection and analysis of the data or in writing the manuscript.Peer reviewedPublisher PD

De Smedt, Ann

Forget, Patrice

Goudman, Lisa

Moens, Maarten

Journal of Clinical Medicine

English

Funding: This study was supported by Medtronic Europe Sàrl through an independent research grant. Medtronic was not involved in the collection and analysis of the data or in writing the manuscript.Peer reviewe

Aberdeen University Research

Determining the Minimal Clinical Important Difference for Medication Quantification Scale III and Morphine Milligram Equivalents in Patients with Failed Back Surgery Syndrome

The Medication Quantification Scale III (MQS) is a tool to represent the negative impact of medication. A reduction in medication can serve as an indicator to evaluate treatment success. However, no cut-off value has yet been determined to evaluate whether a decrease in medication is clinically relevant. Therefore, the objective is to estimate the thresholds for the MQS and morphine milligram equivalents (MMEs) that best identify a clinically relevant important improvement for patients. Data from the Discover registry, in which patients with failed back surgery syndrome were treated with high-dose spinal cord stimulation, were used. Patient satisfaction was utilized to evaluate a clinically important outcome 12 months after stimulation. Anchor-based and distribution-based methods were applied to determine the minimal clinical important difference (MCID). Distribution-based methods revealed a value of 4.28 for the MQS and 33.61 for the MME as MCID. Anchor-based methods indicated a percentage change score of 41.2% for the MQS and 28.2% for the MME or an absolute change score of 4.72 for the MQS and 22.65 for the MME. For assessing a treatment outcome, we recommend using the percentage change score, which better reflects a clinically important outcome and is not severely influenced by high medication intake at baseline

Lisa Goudman

Multidisciplinary Digital Publishing Institute

https://aura.abdn.ac.uk/bitstream/2164/15454/1/Goudman_et_al_JCM_DeterminingTheMinimal_VoR.pdf

Determining the Minimal Clinical Important Difference for Medication Quantification Scale III and Morphine Milligram Equivalents in Patients with Failed Back Surgery Syndrome

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Aberdeen University Research

Multidisciplinary Digital Publishing Institute