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Modifications of gustatory nerve synapses onto nucleus of the solitary tract neurons induced by dietary sodium-restriction during development
Authors
Applegate
Bradley
+51 more
Buchs
Buonomano
Calverley
Colonnier
Colonnier
DeFelipe
Deng
Dunaevsky
Erickson
Erisir
Erisir
Formaker
Frazier
Guillery
Guillery
Halsell
Harris
Hayat
Hill
Hill
Hill
Hubel
Kantor
Katz
King
Kitada
Krimm
Lasiter
Lasiter
Lasiter
Lasiter
Lasiter
Mangold
Mangold
May
May
Mistretta
Peters
Peters
Pierce
Pittman
Schuster
Shepherd
Smith
Sollars
Sollars
Sollars
Thaw
Vogt
Whitehead
Ye
Publication date
1 January 2008
Publisher
'Wiley'
Doi
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on
PubMed
Abstract
The terminal fields of nerves carrying gustatory information to the rat brainstem show a remarkable amount of expansion in the nucleus of the solitary tract (NTS) as a result of early dietary sodium restriction. However, the extent to which these axonal changes represent corresponding changes in synapses is not known. To identify the synaptic characteristics that accompany the terminal field expansion, the greater superficial petrosal (GSP), chorda tympani (CT), and glossopharyngeal (IX) nerves were labeled in rats fed a sodium-restricted diet during pre- and postnatal development. The morphology of these nerve terminals within the NTS region where the terminal fields of all three nerves overlap was evaluated by transmission electron microscopy. Compared to data from control rats, CT axons were the most profoundly affected. The density of CT arbors and synapses quadrupled as a result of the near life-long dietary manipulation. In contrast, axon and synapse densities of GSP and IX nerves were not modified in sodium-restricted rats. Furthermore, compared to controls, CT terminals displayed more instances of contacts with postsynaptic dendritic protrusions and IX terminals synapsed more frequently with dendritic shafts. Thus, dietary sodium restriction throughout pre- and postnatal development had differential effects on the synaptic organization of the three nerves in the NTS. These anatomical changes may underlie the impact of sensory restriction during development on the functional processing of taste information and taste-related behaviors. J. Comp. Neurol. 508:529–541, 2008. © 2008 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/58547/1/21708_ftp.pd
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Deep Blue at the University of Michigan
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