Please read abstract in the article.The National Natural Science Foundation of China; the Ministry of Science and Technology, Taiwan; the Medical Research Council-UK; Fundação para a Ciência e a Tecnologia; the Australian Research Council the European Union’s Horizon 2020 Project Exhaustion ; the Natural Environment Research Council UK; the Australian National Health and Medical Research Council; and an Emerging Leader Fellowship of the Australian National Health and Medical Research Council.http://www.atsjournals.org/journal/ajrccm2023-06-07hj2023Geography, Geoinformatics and Meteorolog

Astrom, Christofer

Bell, Michelle L.

Breitner, Susanne

Cai, Jing

Chen, Renjie

Da Silva, Susana Pereira

De la Cruz Valencia, Cesar

Forsberg, Bertil

Fratianni, Simona

Garland, Rebecca M.

Gasparrini, Antonio

Guo, Yue-Liang Leon

Guo, Yuming

Hashizume, Masahiro

Holobac, Iulian Horia

Honda, Yasushi

Hurtado Diaz, Magali

Iniguez, Carmen

Jaakkola, Jouni J.K.

Kan, Haidong

Katsouyanni, Klea

Lavigne, Eric

Li, Shanshan

Liu, Cong

Maasikmets, Marek

Madureira, Joana

Matus Correa, Patricia

Milojevic, Ai

Ng, Chris Fook Sheng

Orru, Hans

Palomares, Alfonso Diz-Lois

Pan, Shih-Chun

Ragettli, Martina S.

Rao, Shilpa

Ryti, Niilo R.I.

Samoli, Evangelia

Schneider, Alexandra

Schwartz, Joel

Scovronick, Noah

Sera, Francesco

Tobias, Aurelio

Tong, Shilu

Valdes Ortega, Nicolas

Vicedo-Cabrera, Ana Maria

Zanobetti, Antonella

Rationale: The associations between ambient coarse particulate matter (PM2.5-10) and daily mortality are not fully understood on a global scale. Objectives: To evaluate the short-term associations between PM2.5-10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide. Methods: We collected daily mortality (total, cardiovascular, and respiratory) and air pollution data from 205 cities in 20 countries/regions. Concentrations of PM2.5-10 were computed as the difference between inhalable and fine PM. A two-stage time-series analytic approach was applied, with overdispersed generalized linear models and multilevel meta-analysis. We fitted two-pollutant models to test the independent effect of PM2.5-10 from copollutants (fine PM, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide). Exposure-response relationship curves were pooled, and regional analyses were conducted. Measurements and Main Results: A 10 μg/m3 increase in PM2.5-10 concentration on lag 0-1 day was associated with increments of 0.51% (95% confidence interval [CI], 0.18%-0.84%), 0.43% (95% CI, 0.15%-0.71%), and 0.41% (95% CI, 0.06%-0.77%) in total, cardiovascular, and respiratory mortality, respectively. The associations varied by country and region. These associations were robust to adjustment by all copollutants in two-pollutant models, especially for PM2.5. The exposure-response curves for total, cardiovascular, and respiratory mortality were positive, with steeper slopes at lower exposure ranges and without discernible thresholds. Conclusions: This study provides novel global evidence on the robust and independent associations between short-term exposure to ambient PM2.5-10 and total, cardiovascular, and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM2.5-10

Correa, Patricia Matus

Ortega, Nicolas Valdes

Jaakkola, Jouni JK

Ryti, Niilo

Diaz, Magali Hurtado

la Cruz Valencia, César De

Pereira da Silva, Susana

Holobâc, Iulian Horia

Garland, Rebecca M

Íñiguez, Carmen

Åström, Christofer

Ragettli, Martina S

Bell, Michelle L

LSHTM Research Online

Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities.

Rationale: The associations between ambient coarse particulate matter (PM2.5–10) and daily mortality are not fully understood on a global scale. Objectives: To evaluate the short-term associations between PM2.5–10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide. Methods: We collected daily mortality (total, cardiovascular, and respiratory) and air pollution data from 205 cities in 20 countries/regions. Concentrations of PM2.5–10 were computed as the difference between inhalable and fine PM. A two-stage time-series analytic approach was applied, with overdispersed generalized linear models and multilevel meta-analysis. We fitted two-pollutant models to test the independent effect of PM2.5–10 from copollutants (fine PM, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide). Exposure–response relationship curves were pooled, and regional analyses were conducted. Measurements and Main Results: A 10 μg/m3 increase in PM2.5–10 concentration on lag 0–1 day was associated with increments of 0.51% (95% confidence interval [CI], 0.18%–0.84%), 0.43% (95% CI, 0.15%–0.71%), and 0.41% (95% CI, 0.06%–0.77%) in total, cardiovascular, and respiratory mortality, respectively. The associations varied by country and region. These associations were robust to adjustment by all copollutants in two-pollutant models, especially for PM2.5. The exposure–response curves for total, cardiovascular, and respiratory mortality were positive, with steeper slopes at lower exposure ranges and without discernible thresholds. Conclusions: This study provides novel global evidence on the robust and independent associations between short-term exposure to ambient PM2.5–10 and total, cardiovascular, and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM2.5–10.</p

Palomares, Alfonso Diz Lois

Guo, Yue Liang Leon

Pan, Shih Chun

Queensland University of Technology ePrints Archive

Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities

Rationale: The associations between ambient coarse particulate matter (PM2.5-10) and daily mortality are not fully understood on a global scale. Objectives: To evaluate the short-term associations between PM2.5-10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide. Methods: We collected daily mortality (total, cardiovascular, and respiratory) and air pollution data from 205 cities in 20 countries/regions. Concentrations of PM2.5-10 were computed as the difference between inhalable and fine PM. A two-stage time-series analytic approach was applied, with overdispersed generalized linear models and multilevel meta-analysis. We fitted two-pollutant models to test the independent effect of PM2.5-10 from copollutants (fine PM, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide). Exposure-response relationship curves were pooled, and regional analyses were conducted. Measurements and Main Results: A 10 μg/m3 increase in PM2.5-10 concentration on lag 0-1 day was associated with increments of 0.51% (95% confidence interval [CI], 0.18%-0.84%), 0.43% (95% CI, 0.15%-0.71%), and 0.41% (95% CI, 0.06%-0.77%) in total, cardiovascular, and respiratory mortality, respectively. The associations varied by country and region. These associations were robust to adjustment by all copollutants in two-pollutant models, especially for PM2.5. The exposure-response curves for total, cardiovascular, and respiratory mortality were positive, with steeper slopes at lower exposure ranges and without discernible thresholds. Conclusions: This study provides novel global evidence on the robust and independent associations between short-term exposure to ambient PM2.5-10 and total, cardiovascular, and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM2.5-10.Supported by the National Natural Science Foundation of China (92043301, 82030103 [H.K. and C.L.] and 92143301 [R.C.]); the Ministry of Science and Technology, Taiwan (MOST 110–2314-B-002–083 [Y.-L.L.G.]); the Medical Research Council-UK (MR/R013349/1 [A.G.]); Fundação para a Ciência e a Tecnologia through the grant SFRH/BPD/115112/2016 (J.M.); the Australian Research Council (DP210102076 [Y.G.]); the European Union’s Horizon 2020 Project Exhaustion (820655 [A.G., S.R., A.D.-L.P., and A.S.]); the Natural Environment Research Council UK (NE/R009384/1 [A.G.]); the Australian National Health and Medical Research Council (APP2000581, APP1163693, and APP2008813 [Y.G.]); and an Emerging Leader Fellowship of the Australian National Health and Medical Research Council (APP2009866 [S.L.]).Peer reviewe

Jaakkola, Jouni J. K.

Tobías, Aurelio

Digital.CSIC

RATIONALE



The associations between ambient coarse particulate matter (PM2.5-10) and daily mortality is not fully understood at a global scale.



OBJECTIVES



To evaluate the short-term associations between PM2.5-10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide.



METHODS



We collected daily mortality (total, cardiovascular, respiratory) and air pollution data from 205 cities in 20 countries/regions. Concentrations of PM2.5-10 were computed as the difference between inhalable and fine particulate matter. A two-stage time-series analytic approach was applied, with over-dispersed generalized linear models and multilevel meta-analysis. We fitted two-pollutant models to test the independent effect of PM2.5-10 from co-pollutants (fine particulate matter, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide). Exposure-response relationship curves were pooled and regional analyses were conducted.



MEASUREMENTS AND MAIN RESULTS



A 10 μg/m3 increase in PM2.5-10 concentration on lag 0-1 day was associated with increments of 0.51% (95% confidence interval [CI]: 0.18%, 0.84%), 0.43% (95%CI: 0.15%, 0.71%) and 0.41% (95%CI: 0.06%, 0.77%) in total, cardiovascular, and respiratory mortality, respectively. The associations varied by country and region. These associations were robust to adjustment by all co-pollutants in two-pollutant models, especially for PM2.5. The exposure-response curves for total, cardiovascular, and respiratory mortality were positive, with steeper slopes at lower exposure ranges and without discernible thresholds.



CONCLUSIONS



This study provides novel global evidence on the robust and independent associations between short-term exposure to ambient PM2.5-10 and total, cardiovascular and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM2.5-10

Jaakkola, Jouni J K

Samoli, Evangelina

Valencia, César De la Cruz

Silva, Susana Pereira da

Bern Open Repository and Information System (BORIS)

UPSpace at the University of Pretoria

Coarse particulate air pollution and daily mortality a global study in 205 cities

https://repository.up.ac.za/bitstream/2263/89906/1/Liu_Coarse_2022.pdf

Coarse particulate air pollution and daily mortality a global study in 205 cities

Abstract

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LSHTM Research Online

Queensland University of Technology ePrints Archive

Digital.CSIC

Bern Open Repository and Information System (BORIS)

UPSpace at the University of Pretoria