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Insulin-like growth factor-I (IGF-I) and IGF binding protein-5 in Schwann cell differentiation
Authors
Aplin
Baines
+49 more
Bengtsson
Bolsover
Brown
Cai
Clark
Cooper
Cunningham
Devreotes
Diamond
DiMilla
Downey
Francis
Furie
Furie
Giancotti
Grazi
Hasten
Hendey
Hendey
Hendey
Hynes
Jaconi
Jaconi
Janson
Juliano
Laemmli
Lawson
Loike
Mandeville
Mandeville
Mandeville
Marks
Marks
Marks
Matthes
Maxfield
Petersen
Ramsey
Resales
Scanlon
Schmalstieg
Sheterline
Steinberg
Stendahl
Stossel
Wang
Wang
Wells
Zigmond
Publication date
1 May 1997
Publisher
'Wiley'
Doi
Abstract
Schwann cells (SCs) are the myelin producing cells of the peripheral nervous system. During development, SCs cease proliferation and differentiate into either a myelin-forming or non-myelin forming mature phenotype. We are interested in the role of insulin-like growth factor-I (IGF-I) in SC development. We have shown previously SCs proliferate in response to IGF-I in vitro. In the current study, we investigated the role of IGF-I in SC differentiation. SC differentiation was determined by morphological criteria and expression of myelin proteins. Addition of 1 mM 8-bromo cyclic AMP (cAMP) or growth on Matrigel matrix decreased proliferation and induced differentiation of SCs. IGF-I enhanced both cAMP and Matrigel matrix-induced SC differentiation, as assessed by both morphological criteria and myelin gene expression. Cultured SCs also express IGF binding protein-5 (IGFBP-5), which can modulate the actions of IGF-I. We examined the expression of IGFBP-5 during SC differentiation. Both cAMP and Matrigel matrix treatment enhanced IGFBP-5 protein expression and cAMP increased IGFBP-5 gene expression five fold. These findings suggest IGF-I potentiates SC differentiation. The concomitant up-regulation of IGFBP-5 may play a role in targeting IGF-I to SCs and thus increase local IGF-I bioavailability. J. Cell. Physiol. 171:161–167, 1997. © 1997 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34438/1/6_ftp.pd
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