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Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat
Authors
Abdulla
Aitkin
+146 more
Alheid
Altschuler
Anton
Ardati
Borisova
Bunzow
Butour
Byrum
Cabeza de Vaca
Ceccatelli
Champion
Champion
Champion
Chen
Civelli
Connor
Connor
Cortes
Davis
Dawson-Basoa
Devine
Devine
Doi
Dooley
Dooley
Faber
Florin
Florin
Florin
Fukuda
Gintzler
Giuliani
Gonzales
Gorski
Grisel
Guerrini
Guillamon
Gumusel
Halford
Hao
Hara
Heinricher
Henderson
Herman
Herman
Houtani
Ikeda
Jacobson
Jakab
Jenck
Jhamandas
Kachaturian
Kalkman
Kapusta
King
King
Kiyama
Knoflach
Koob
Lachowicz
Lai
Leventhal
Liebel
Lou
Ma
Madeira
Makman
Mamiya
Manabe
Mansour
Mansour
Mansour
Mansour
Mansour
Marchese
Mathis
Meng
Meunier
Minami
Mogil
Mogil
Mollereau
Mollereau
Mollereau
Monteillet-Agius
Montes
Montiel
Morgan
Murphy
Neal
Neil
Nicol
Nishi
Nishizuka
Noble
Nothacker
Okuda-Ashitaka
Pan
Paxinos
Plotsky
Pomonis
Quigley
Reinscheid
Reinscheid
Reinscheid
Ribeiro-da-Silva
Riedl
Rossi
Rossi
Saito
Saito
Saito
Sandin
Saper
Schuligoi
Schulz
Schwerdtfeger
Shimohigashi
Sim
Sim
Simerly
Simerly
Sinchak
Spencer
Standifer
Stanfa
Stratford
Swanson
Tian
Tian
Ueda
Urban
Vaughan
Vaughan
Wagner
Wang
Wang
Watson
Wick
Wu
Xu
Yamamoto
Yu
Yu
Zamboni
Zhu
Publication date
19 April 1999
Publisher
'Wiley'
Doi
Abstract
Orphanin FQ (OFQ) is the endogenous agonist of the opioid receptor-like receptor (ORL-1). It and its precursor, prepro-OFQ, exhibit structural features suggestive of the opioid peptides. A cDNA encoding the OFQ precursor sequence in the rat recently has been cloned, and the authors recently generated a polyclonal antibody directed against the OFQ peptide. In the present study, the authors used in situ hybridization and immunohistochemistry to examine the distribution of OFQ peptide and mRNA in the central nervous system of the adult rat. OFQ immunoreactivity and prepro-OFQ mRNA expression correlated virtually in all brain areas studied. In the forebrain, OFQ peptide and mRNA were prominent in the neocortex endopiriform nucleus, claustrum, lateral septum, ventral forebrain, hypothalamus, mammillary bodies, central and medial nuclei of the amygdala, hippocampal formation, paratenial and reticular nuclei of the thalamus, medial habenula, and zona incerta. No OFQ was observed in the pineal or pituitary glands. In the brainstem, OFQ was prominent in the ventral tegmental area, substantia nigra, nucleus of the posterior commissure, central gray, nucleus of Darkschewitsch, peripeduncular nucleus, interpeduncular nucleus, tegmental nuclei, locus coeruleus, raphe complex, lateral parabrachial nucleus, inferior olivary complex, vestibular nuclear complex, prepositus hypoglossus, solitary nucleus, nucleus ambiguous, caudal spinal trigeminal nucleus, and reticular formation. In the spinal cord, OFQ was observed throughout the dorsal and ventral horns. The wide distribution of this peptide provides support for its role in a multitude of functions, including not only nociception but also motor and balance control, special sensory processing, and various autonomic and physiologic processes. J. Comp. Neurol. 406:503–547, 1999. © 1999 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34452/1/7_ftp.pd
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