524 research outputs found

    Prediction of sleep disturbances in korean rural elderly through longitudinal follow up

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    Objectives: Sleep disturbance is a very rapidly growing disease with aging. The purpose of this study was to investigate the prevalence of sleep disturbances and its predictive factors in a three-year cohort study of people aged 60 years and over in Korea. Methods: In 2012 and 2014, we obtained data from a survey of the Korean Social Life, Health, and Aging Project. We asked participants if they had been diagnosed with stroke, myocardial infarction, angina pectoris, arthritis, pulmonary tuberculosis, asthma, cataract, glaucoma, hepatitis B, urinary incontinence, prostate hypertrophy, cancer, osteoporosis, hypertension, diabetes, hyperlipidemia, or metabolic syndrome. Cognitive function was assessed using the Mini-Mental State Examination for dementia screening in 2012, and depression was assessed using the Center for Epidemiologic Studies Depression Scale in 2012 and 2014. In 2015, a structured clinical interview for Axis I psychiatric disorders was administered to 235 people, and sleep disturbance was assessed using the Pittsburgh Sleep Quality Index. The perceived stress scale and the State-trait Anger Expression Inventory were also administered. Logistic regression analysis was used to predict sleep disturbance by gender, age, education, depression score, number of coexisting diseases in 2012 and 2014, current anger score, and perceived stress score. Results: Twenty-seven percent of the participants had sleep disturbances. Logistic regression analysis showed that the number of medical diseases three years ago, the depression score one year ago, and the current perceived stress significantly predicted sleep disturbances. Conclusion: Comorbid medical disease three years previous and depressive symptoms evaluated one year previous were predictive of current sleep disturbances. Further studies are needed to determine whether treatment of medical disease and depressive symptoms can improve sleep disturbances.ope

    ๋‹ค๋ฌธํ™” ํ™˜๊ฒฝ ๊ต์œก(MCEE) ๋‚ด์šฉ ์š”์†Œ ๋ถ„์„ํ‹€ ๊ฐœ๋ฐœ ๋ฐ ์ดˆ๋“ฑํ•™๊ต 3ยท4ํ•™๋…„๊ตฐ ๊ณผํ•™ ๊ต๊ณผ์„œ ๋ถ„์„์„ ์ค‘์‹ฌ์œผ๋กœ

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    ํ•™์œ„๋…ผ๋ฌธ(์„์‚ฌ) -- ์„œ์šธ๋Œ€ํ•™๊ต๋Œ€ํ•™์› : ์‚ฌ๋ฒ”๋Œ€ํ•™ ๊ณผํ•™๊ต์œก๊ณผ(์ง€๊ตฌ๊ณผํ•™์ „๊ณต), 2023. 2. Sonya Nichole Martin.Science education is receiving new demands beyond learning about scientific knowledge or scientific methods. The Ministry of Education is asking science education to incorporate cross curricular learning topics. In particular, multicultural education and environmental education, one of the topics of cross curricular learning, are becoming increasingly important in society due to the rapid progress toward today's multicultural society and the climate change crisis. In order to respond to these demands, this study explored whether multicultural education and environmental education can be handled simultaneously within science education. In particular, it was considered values education in that both multicultural education and environmental education are education that foster specific values and lead to changes in attitudes and practices. Therefore, the common content elements shared by multicultural education and environmental education were set as the common values shared by the two education, and the possibility of coexistence of values education in science education was explored by examining how much it was included in science textbooks. To this end, the study was largely conducted in two stages. In the first stage of the study, multicultural environmental education content element analysis framework(hereinafter referred to as the MCEE analysis framework) was developed to extract common content elements of multicultural education and environmental education. To this end, the 2015 revised secondary environmental curriculum achievement standards were analyzed using the multicultural content element analysis framework of Cho et al.(2009) to explore the intersection point of multicultural education and environmental education. After that, by conducting a literature analysis related to multicultural education, environmental education, and multicultural environmental education, the basis for core elements to be added to the MCEE analysis framework was identified. In order to verify the applicability of the MCEE analysis framework, one publisher of science textbook of 3-4 grade elementary school was preliminarily analyzed. Finally, face validity and content validity were secured through expert validate procedures. The research results derived in the first stage of the study are as follows. The MCEE analysis framework consists of the common content elements of multicultural education and environmental education, that is, the content elements of multicultural environmental education(hereinafter referred to as MCEE content element). Specifically, MCEE analysis framework consists of core elements, sub elements, and detailed questions, and core elements correspond to five categories: identity, diversity, human rights and equality, interdependence and coexistence, and participation. In the second stage of the study, seven publishers of science textbooks of 3-4 grade elementary school were analyzed using the developed MCEE analysis framework and the results were compared. For textbook analysis, qualitative content analysis method and quantitative content analysis method were used at the same time. Textbook analysis data was compared and analyzed by publisher, core elements and sub elements, and grade, and the analysis results were qualitatively interpreted and critically evaluated in this process. The research results derived in the second stage of the study are as follows. The MCEE content element is significantly included in the science textbooks of the 3-4 grade elementary school. However, there was an imbalance in the quantity and quality of the core and sub elements included. In addition, it was confirmed that it was necessary to reconsider how to properly reflect the elements in the science textbook. Nevertheless, it was found that MCEE content element can be sufficiently reflected while maintaining the current textbook composition through best practices in which MCEE content elements are appropriately reflected already. Thus, this research concludes that values education is possible within science education. This study shows that it is possible to incorporate MCEE content element as values into science education. This will be meaningful in that it becomes a way to respond to the policy demands of the curriculum for science education and to expand the scope of science education. In addition, it suggests the possibility of field application of the research results in that it derived the possibility of connecting science education and values education by focusing on textbooks used as a major educational medium in the educational field. Based on this study, additional efforts in various levels are required to expand the horizon of science education to values education. For example, when constructing science textbook, the perception and practice of including MCEE content element should be supported. In addition, it is necessary to develop a science education program that reflects MCEE content element and provide opportunities for prospective and incumbent teachers and students who are the subjects of education to experience them.๊ณผํ•™๊ต์œก์€ ๊ณผํ•™ ์ง€์‹ ๋˜๋Š” ๊ณผํ•™์  ๋ฐฉ๋ฒ•์— ๋Œ€ํ•œ ํ•™์Šต์„ ๋„˜์–ด ์ƒˆ๋กœ์šด ์š”๊ตฌ๋ฅผ ๋ฐ›๊ณ  ์žˆ๋‹ค. ํŠนํžˆ ๊ต์œก๋ถ€๋Š” ๊ณผํ•™๊ต์œก์— ๋ฒ”๊ต๊ณผ ํ•™์Šต ์ฃผ์ œ๋ฅผ ์ ‘๋ชฉํ•  ๊ฒƒ์„ ์š”์ฒญํ•˜๊ณ  ์žˆ๋‹ค. ๋ฒ”๊ต๊ณผ ํ•™์Šต ์ฃผ์ œ ์ค‘ ํ•˜๋‚˜์ธ ๋‹ค๋ฌธํ™”๊ต์œก๊ณผ ํ™˜๊ฒฝ๊ต์œก์€ ์˜ค๋Š˜๋‚  ๋‹ค๋ฌธํ™” ์‚ฌํšŒ๋กœ์˜ ๊ธ‰์†ํ•œ ์ „์ง„๊ณผ ๊ธฐํ›„ ๋ณ€ํ™” ์œ„๊ธฐ์— ๋”ฐ๋ผ ์‚ฌํšŒ์ ์œผ๋กœ๋„ ๊ทธ ์ค‘์š”์„ฑ์ด ์ ์ฐจ ์ปค์ง€๊ณ  ์žˆ๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋Š” ์ด๋Ÿฌํ•œ ์š”๊ตฌ์— ์‘๋‹ตํ•˜๊ธฐ ์œ„ํ•ด ๊ณผํ•™๊ต์œก ์•ˆ์—์„œ ๋‹ค๋ฌธํ™”๊ต์œก๊ณผ ํ™˜๊ฒฝ๊ต์œก์„ ๋™์‹œ์— ๋‹ค๋ฃฐ ์ˆ˜ ์žˆ๋Š”์ง€๋ฅผ ํƒ์ƒ‰ํ•˜์˜€์œผ๋ฉฐ, ๋‹ค๋ฌธํ™”๊ต์œก๊ณผ ํ™˜๊ฒฝ๊ต์œก์ด ๋ชจ๋‘ ํŠน์ •ํ•œ ๊ฐ€์น˜๋ฅผ ํ•จ์–‘ํ•˜๋„๋ก ํ•˜๊ณ  ์ด๋ฅผ ํ†ตํ•ด ํƒœ๋„์™€ ์‹ค์ฒœ์˜ ๋ณ€ํ™”๋ฅผ ์ด๋Œ๊ณ ์ž ํ•œ๋‹ค๋Š” ์ ์—์„œ ๊ฐ€์น˜๊ต์œก์ด๋ผ๊ณ  ๋ณด์•˜๋‹ค. ๋”ฐ๋ผ์„œ ๋‹ค๋ฌธํ™”๊ต์œก๊ณผ ํ™˜๊ฒฝ๊ต์œก์ด ๊ณต์œ ํ•˜๋Š” ๊ณตํ†ต ๋‚ด์šฉ ์š”์†Œ๋ฅผ ๋‘ ๊ต์œก์ด ๊ณต์œ ํ•˜๋Š” ๊ณตํ†ต ๊ฐ€์น˜๋กœ ์„ค์ •ํ•˜๊ณ  ์ด๊ฒƒ์ด ๊ณผํ•™ ๊ต๊ณผ์„œ์— ์–ผ๋งˆ๋‚˜ ํฌํ•จ๋˜์–ด ์žˆ๋Š”์ง€๋ฅผ ์‚ดํŽด๋ด„์œผ๋กœ์จ ๊ถ๊ทน์ ์œผ๋กœ ๊ณผํ•™๊ต์œก์—์„œ ๊ฐ€์น˜๊ต์œก์˜ ๊ณต์กด ๊ฐ€๋Šฅ์„ฑ์„ ํƒ์ƒ‰ํ•˜์˜€๋‹ค. ์ด๋ฅผ ์œ„ํ•ด ํฌ๊ฒŒ 2๋‹จ๊ณ„๋กœ ์—ฐ๊ตฌ๋ฅผ ์ง„ํ–‰ํ•˜์˜€๋‹ค. ์—ฐ๊ตฌ 1๋‹จ๊ณ„์—์„œ๋Š” ๋‹ค๋ฌธํ™”๊ต์œก๊ณผ ํ™˜๊ฒฝ๊ต์œก์˜ ๊ณตํ†ต ๋‚ด์šฉ ์š”์†Œ๋ฅผ ์ถ”์ถœํ•  ์ˆ˜ ์žˆ๋Š” ๋‹ค๋ฌธํ™” ํ™˜๊ฒฝ ๊ต์œก ๋‚ด์šฉ ์š”์†Œ ๋ถ„์„ํ‹€(์ดํ•˜ MCEE ๋ถ„์„ํ‹€)์„ ๊ฐœ๋ฐœํ•˜์˜€๋‹ค. ์ด๋ฅผ ์œ„ํ•ด ๋จผ์ € 2015 ๊ฐœ์ • ์ค‘๋“ฑ ํ™˜๊ฒฝ๊ณผ ๊ต์œก๊ณผ์ • ์„ฑ์ทจ๊ธฐ์ค€์„ ์กฐ์˜๋‹ฌ ๋“ฑ(2009)์˜ ๋‹ค๋ฌธํ™”์  ๋‚ด์šฉ ์š”์†Œ ๋ถ„์„ํ‹€์„ ํ™œ์šฉํ•˜์—ฌ ๋ถ„์„ํ•˜๊ณ , ๋‹ค๋ฌธํ™”๊ต์œก๊ณผ ํ™˜๊ฒฝ๊ต์œก์˜ ๊ต์ฐจ ์ง€์ ์„ ํƒ์ƒ‰ํ•˜์˜€๋‹ค. ์ดํ›„ ๋‹ค๋ฌธํ™”๊ต์œก, ํ™˜๊ฒฝ๊ต์œก, ๋‹ค๋ฌธํ™” ํ™˜๊ฒฝ ๊ต์œก ๊ด€๋ จ ๋ฌธํ—Œ ๋ถ„์„์„ ์ˆ˜ํ–‰ํ•จ์œผ๋กœ์จ ๋ถ„์„ํ‹€์— ์ถ”๊ฐ€ํ•ด์•ผ ํ•  ํ•ต์‹ฌ ์š”์†Œ์˜ ๊ทผ๊ฑฐ๋ฅผ ํ™•๋ณดํ•˜์˜€๋‹ค. ๋ถ„์„ํ‹€์˜ ์ ์šฉ ๊ฐ€๋Šฅ์„ฑ์„ ๊ฒ€์ฆํ•˜๊ณ ์ž ์ดˆ๋“ฑํ•™๊ต 3ยท4ํ•™๋…„๊ตฐ ๊ณผํ•™ ๊ต๊ณผ์„œ 1์ข…์„ ์˜ˆ๋น„ ๋ถ„์„ํ•˜์˜€๋‹ค. ๋งˆ์ง€๋ง‰์œผ๋กœ ์ „๋ฌธ๊ฐ€ ํƒ€๋‹น๋„ ๊ฒ€์ฆ์„ ๊ฑฐ์ณ ์•ˆ๋ฉด ํƒ€๋‹น๋„์™€ ๋‚ด์šฉ ํƒ€๋‹น๋„๋ฅผ ํ™•๋ณดํ•˜์˜€๋‹ค. ์—ฐ๊ตฌ 1๋‹จ๊ณ„์—์„œ ๋„์ถœํ•œ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๋Š” ๋‹ค์Œ๊ณผ ๊ฐ™๋‹ค. MCEE ๋ถ„์„ํ‹€์€ ๋‹ค๋ฌธํ™”๊ต์œก๊ณผ ํ™˜๊ฒฝ๊ต์œก์˜ ๊ณตํ†ต ๋‚ด์šฉ ์š”์†Œ(์ดํ•˜ MCEE ๋‚ด์šฉ ์š”์†Œ)๋กœ ๊ตฌ์„ฑ๋œ๋‹ค. ๊ตฌ์ฒด์ ์œผ๋กœ๋Š” ํ•ต์‹ฌ ์š”์†Œ, ํ•˜์œ„ ์š”์†Œ, ์„ธ๋ถ€ ์งˆ๋ฌธ์œผ๋กœ ์ด๋ฃจ์–ด์ ธ ์žˆ์œผ๋ฉฐ, ํ•ต์‹ฌ ์š”์†Œ๋Š” ์ •์ฒด์„ฑ, ๋‹ค์–‘์„ฑ, ์ธ๊ถŒ๊ณผ ํ‰๋“ฑ, ์ƒํ˜ธ์˜์กด์„ฑ๊ณผ ๊ณต์กด, ์ฐธ์—ฌ๋กœ ์ด 5๊ฐ€์ง€์ด๋‹ค. ์—ฐ๊ตฌ 2๋‹จ๊ณ„์—์„œ๋Š” ๊ฐœ๋ฐœํ•œ MCEE ๋ถ„์„ํ‹€์„ ํ™œ์šฉํ•˜์—ฌ ์ดˆ๋“ฑํ•™๊ต 3ยท4ํ•™๋…„๊ตฐ ๊ณผํ•™ ๊ต๊ณผ์„œ 7์ข…์„ ๋ถ„์„ํ•˜๊ณ  ๊ทธ ๊ฒฐ๊ณผ๋ฅผ ๋น„๊ตํ•˜์˜€๋‹ค. ๊ต๊ณผ์„œ ๋ถ„์„์„ ์œ„ํ•ด ์งˆ์  ๋‚ด์šฉ๋ถ„์„ ๋ฐฉ๋ฒ•๊ณผ ์–‘์  ๋‚ด์šฉ๋ถ„์„ ๋ฐฉ๋ฒ•์„ ๋™์‹œ์— ํ™œ์šฉํ•˜์˜€๋‹ค. ๊ต๊ณผ์„œ ๋ถ„์„ ์ž๋ฃŒ๋ฅผ ์ถœํŒ์‚ฌ๋ณ„, ํ•ต์‹ฌ ์š”์†Œ ๋ฐ ํ•˜์œ„ ์š”์†Œ๋ณ„, ํ•™๋…„๋ณ„๋กœ ๋น„๊ต ๋ถ„์„ํ•˜์˜€์œผ๋ฉฐ, ์ด ๊ณผ์ •์—์„œ ๋ถ„์„ ๊ฒฐ๊ณผ๋ฅผ ์งˆ์ ์œผ๋กœ ํ•ด์„ํ•˜๊ณ  ๋น„ํŒ์ ์œผ๋กœ ํ‰๊ฐ€ํ•˜์˜€๋‹ค. ์—ฐ๊ตฌ 2๋‹จ๊ณ„์—์„œ ๋„์ถœํ•œ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๋Š” ๋‹ค์Œ๊ณผ ๊ฐ™๋‹ค. MCEE ๋‚ด์šฉ ์š”์†Œ๋Š” ์ดˆ๋“ฑํ•™๊ต 3ยท4ํ•™๋…„๊ตฐ ๊ณผํ•™ ๊ต๊ณผ์„œ์ƒ์— ์ƒ๋‹นํžˆ ํฌํ•จ๋˜์–ด ์žˆ๋‹ค๋Š” ๊ฒƒ์ด๋‹ค. ๊ทธ๋Ÿฌ๋‚˜ ํฌํ•จ๋˜์–ด ์žˆ๋Š” ํ•ต์‹ฌ ์š”์†Œ ๋ฐ ํ•˜์œ„ ์š”์†Œ์˜ ์–‘๊ณผ ์งˆ์—๋Š” ๋ถˆ๊ท ํ˜•์ด ์กด์žฌํ•˜์˜€์œผ๋ฉฐ, ๋ฐ˜์˜์‹œ์˜ ์ ์ ˆ์„ฑ์— ๋Œ€ํ•ด ์žฌ๊ณ ํ•ด ๋ณผ ํ•„์š”๊ฐ€ ์žˆ์—ˆ๋‹ค. ๊ทธ๋Ÿผ์—๋„ ๋ถˆ๊ตฌํ•˜๊ณ , MCEE ๋‚ด์šฉ ์š”์†Œ๊ฐ€ ๋‹ค์ฑ„๋กญ๊ณ  ์ ์ ˆํ•˜๊ฒŒ ๋ฐ˜์˜๋œ ์šฐ์ˆ˜ ์‚ฌ๋ก€๋ฅผ ๊ทผ๊ฑฐ๋กœ ํ•˜์—ฌ ํ˜„์žฌ์˜ ๊ณผํ•™ ๊ต๊ณผ์„œ์˜ ๊ตฌ์„ฑ ํ˜•์‹๊ณผ ๋‚ด์šฉ์„ ์œ ์ง€ํ•˜๋ฉด์„œ๋„ MCEE ๋‚ด์šฉ ์š”์†Œ๋ฅผ ์ถฉ๋ถ„ํžˆ ๋ฐ˜์˜ํ•  ์ˆ˜ ์žˆ๋‹ค๋Š” ๊ฒฐ๋ก ์„ ๋‚ด๋ฆด ์ˆ˜ ์žˆ์—ˆ๋‹ค. ์ด๋Š” ๊ณผํ•™๊ต์œก ์•ˆ์—์„œ ๊ฐ€์น˜๊ต์œก์ด ๊ฐ€๋Šฅํ•˜๋‹ค๋Š” ๊ฒฐ๋ก ์œผ๋กœ ๊ท€๊ฒฐ๋œ๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋Š” ๊ณผํ•™๊ต์œก์— MCEE ๋‚ด์šฉ ์š”์†Œ, ์ฆ‰ ๊ฐ€์น˜๋ฅผ ์ ‘๋ชฉ์‹œํ‚ค๋Š” ๊ฒƒ์ด ๊ฐ€๋Šฅํ•˜๋‹ค๋Š” ๊ฒƒ์„ ๋ณด์—ฌ์ค€๋‹ค. ์ด๋Š” ๊ณผํ•™๊ต์œก์— ๋Œ€ํ•œ ๊ต์œก๊ณผ์ •์˜ ์ •์ฑ…์  ์š”๊ตฌ์— ์‘๋‹ตํ•˜๋Š” ํ•˜๋‚˜์˜ ๋ฐฉ์•ˆ์ด ๋œ๋‹ค๋Š” ์ ๊ณผ ๊ณผํ•™๊ต์œก์˜ ๋ฒ”์œ„๋ฅผ ํ™•์žฅํ•œ๋‹ค๋Š” ์ ์—์„œ ์˜๋ฏธ๊ฐ€ ์žˆ์„ ๊ฒƒ์ด๋‹ค. ๋˜ํ•œ, ๊ต์œก ํ˜„์žฅ์—์„œ ์ฃผ์š”ํ•œ ๊ต์œก ๋งค์ฒด๋กœ ํ™œ์šฉ๋˜๋Š” ๊ต๊ณผ์„œ๋ฅผ ์ค‘์‹ฌ์œผ๋กœ ์—ฐ๊ตฌํ•˜์—ฌ ๊ณผํ•™๊ต์œก๊ณผ ๊ฐ€์น˜๊ต์œก์˜ ์—ฐ๊ฒฐ ๊ฐ€๋Šฅ์„ฑ์„ ๋ชจ์ƒ‰ํ–ˆ๋‹ค๋Š” ์ ์—์„œ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ์˜ ํ˜„์žฅ ์ ์šฉ ๊ฐ€๋Šฅ์„ฑ์„ ์‹œ์‚ฌํ•œ๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋ฅผ ํ† ๋Œ€๋กœ ๊ณผํ•™๊ต์œก์˜ ์ง€ํ‰์„ ๊ฐ€์น˜๊ต์œก์œผ๋กœ๊นŒ์ง€ ๋„“ํžˆ๊ธฐ ์œ„ํ•ด์„œ๋Š” ์—ฌ๋Ÿฌ ์ฐจ์›์—์„œ์˜ ๋…ธ๋ ฅ์ด ์ถ”๊ฐ€๋กœ ์š”๊ตฌ๋œ๋‹ค. ์˜ˆ๋ฅผ ๋“ค์–ด, ๊ณผํ•™ ๊ต๊ณผ์„œ๋ฅผ ๊ตฌ์„ฑํ•  ๋•Œ MCEE ๋‚ด์šฉ ์š”์†Œ๋ฅผ ํฌํ•จ์‹œํ‚ค๋ ค๋Š” ์ธ์‹๊ณผ ์‹ค์ฒœ์ด ๋’ท๋ฐ›์นจ๋˜์–ด์•ผ ํ•  ๊ฒƒ์ด๋‹ค. ๋˜ํ•œ, MCEE ๋‚ด์šฉ ์š”์†Œ๋ฅผ ๋ฐ˜์˜ํ•œ ๊ณผํ•™๊ต์œก ํ”„๋กœ๊ทธ๋žจ์„ ๊ฐœ๋ฐœํ•˜๊ณ , ์ด๋ฅผ ๊ต์œก์˜ ์ฃผ์ฒด์ธ ์˜ˆ๋น„ ๋ฐ ํ˜„์ง ๊ต์‚ฌ์™€ ํ•™์ƒ๋“ค์ด ๊ฒฝํ—˜ํ•  ์ˆ˜ ์žˆ๋Š” ๊ธฐํšŒ๋ฅผ ์ œ๊ณตํ•ด์•ผ ํ•  ๊ฒƒ์ด๋‹ค.์ œ 1 ์žฅ ์„œ๋ก  1 ์ œ 1 ์ ˆ ์—ฐ๊ตฌ์˜ ํ•„์š”์„ฑ ๋ฐ ๋ชฉ์  1 1. ์—ฐ๊ตฌ์˜ ๋ฐฐ๊ฒฝ๊ณผ ํ•„์š”์„ฑ 1 2. ์—ฐ๊ตฌ์˜ ๋ชฉ์  5 3. ์—ฐ๊ตฌ์˜ ํ•œ๊ณ„์  6 ์ œ 2 ์ ˆ ์—ฐ๊ตฌ ๋ฌธ์ œ 7 ์ œ 3 ์ ˆ ์šฉ์–ด์˜ ์ •์˜ 8 1. ๊ฐ€์น˜๊ต์œก 8 2. ๋‹ค๋ฌธํ™”๊ต์œก 9 3. ํ™˜๊ฒฝ๊ต์œก 9 4. ๋‹ค๋ฌธํ™” ํ™˜๊ฒฝ ๊ต์œก 10 5. ๋‹ค๋ฌธํ™” ํ™˜๊ฒฝ ๊ต์œก ๋‚ด์šฉ ์š”์†Œ 11 ์ œ 2 ์žฅ ์ด๋ก ์  ๋ฐฐ๊ฒฝ 12 ์ œ 1 ์ ˆ ๊ณผํ•™๊ต์œก 12 1. ๊ณผํ•™๊ต์œก์—์„œ์˜ ๊ฐ€์น˜๊ต์œก 12 2. ๊ณผํ•™๊ต์œก์—์„œ์˜ ๋‹ค๋ฌธํ™”๊ต์œก 20 3. ๊ณผํ•™๊ต์œก์—์„œ์˜ ํ™˜๊ฒฝ๊ต์œก 23 ์ œ 2 ์ ˆ ๋‹ค๋ฌธํ™”๊ต์œก๊ณผ ํ™˜๊ฒฝ๊ต์œก 28 1. ๋‹ค๋ฌธํ™”๊ต์œก์˜ ์žฌ๊ฐœ๋…ํ™” 28 2. ๊ฐ€์น˜๊ต์œก์œผ๋กœ์„œ์˜ ๋‹ค๋ฌธํ™”๊ต์œก 29 3. ๊ฐ€์น˜๊ต์œก์œผ๋กœ์„œ์˜ ํ™˜๊ฒฝ๊ต์œก 31 ์ œ 3 ์ ˆ ๋‹ค๋ฌธํ™” ํ™˜๊ฒฝ๊ต์œก 34 ์ œ 3 ์žฅ ์—ฐ๊ตฌ ๋ฐฉ๋ฒ• 40 ์ œ 1 ์ ˆ ์—ฐ๊ตฌ ๋ฐฉ๋ฒ•์˜ ๊ฐœ์š” 40 ์ œ 2 ์ ˆ ์—ฐ๊ตฌ ๋ฐฉ๋ฒ• 43 1. ๋‚ด์šฉ๋ถ„์„ ์—ฐ๊ตฌ 43 2. ํƒ€๋‹น๋„ ๊ฒ€์ฆ 46 ์ œ 3 ์ ˆ ์—ฐ๊ตฌ ์ ˆ์ฐจ 50 1. MCEE ๋ถ„์„ํ‹€ ๊ฐœ๋ฐœ ์ ˆ์ฐจ 50 1) 2015 ๊ฐœ์ • ์ค‘๋“ฑ ํ™˜๊ฒฝ๊ณผ ๊ต์œก๊ณผ์ • ๋ถ„์„ 50 2) ๋ฌธํ—Œ ๋ถ„์„ 55 3) ๊ณผํ•™ ๊ต๊ณผ์„œ ์˜ˆ๋น„ ๋ถ„์„ 59 4) ์ „๋ฌธ๊ฐ€ ํƒ€๋‹น๋„ ๊ฒ€์ฆ 62 2. MCEE ๋ถ„์„ํ‹€์„ ํ™œ์šฉํ•œ ๊ต๊ณผ์„œ ๋ถ„์„ ์ ˆ์ฐจ 66 1) ์ดˆ๋“ฑํ•™๊ต 3ยท4ํ•™๋…„๊ตฐ ๊ณผํ•™ ๊ต๊ณผ์„œ ๋ถ„์„ 66 2) ๊ต๊ณผ์„œ ๋ถ„์„ ๊ฒฐ๊ณผ ๋น„๊ต ๋ฐ ํ•ด์„๊ณผ ๋น„ํŒ์  ํ‰๊ฐ€ 71 ์ œ 4 ์žฅ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ ๋ฐ ๋…ผ์˜ 72 ์ œ 1 ์ ˆ MCEE ๋ถ„์„ํ‹€ ๊ฐœ๋ฐœ 72 1. 2015 ๊ฐœ์ • ์ค‘๋“ฑ ํ™˜๊ฒฝ๊ณผ ๊ต์œก๊ณผ์ • ๋ถ„์„์„ ํ†ตํ•œ 1์ฐจ ๊ฐœ๋ฐœ 72 2. ๋ฌธํ—Œ ๋ถ„์„์„ ํ†ตํ•œ 2์ฐจ ๊ฐœ๋ฐœ 79 3. ๊ณผํ•™ ๊ต๊ณผ์„œ ์˜ˆ๋น„ ๋ถ„์„์„ ํ†ตํ•œ 3์ฐจ ๊ฐœ๋ฐœ 88 4. ํƒ€๋‹น๋„ ๊ฒ€์ฆ์„ ํ†ตํ•œ ์ตœ์ข…์•ˆ ๊ฐœ๋ฐœ 92 ์ œ 2 ์ ˆ MCEE ๋ถ„์„ํ‹€์„ ํ™œ์šฉํ•œ ๊ต๊ณผ์„œ ๋ถ„์„ 96 1. ์ดˆ๋“ฑํ•™๊ต 3ยท4ํ•™๋…„๊ตฐ ๊ณผํ•™ ๊ต๊ณผ์„œ ๋ถ„์„ 96 1) A ๊ต๊ณผ์„œ ๋ถ„์„ ๊ฒฐ๊ณผ 96 2) B ๊ต๊ณผ์„œ ๋ถ„์„ ๊ฒฐ๊ณผ 98 3) C ๊ต๊ณผ์„œ ๋ถ„์„ ๊ฒฐ๊ณผ 101 4) D ๊ต๊ณผ์„œ ๋ถ„์„ ๊ฒฐ๊ณผ 102 5) E ๊ต๊ณผ์„œ ๋ถ„์„ ๊ฒฐ๊ณผ 104 6) F ๊ต๊ณผ์„œ ๋ถ„์„ ๊ฒฐ๊ณผ 106 7) G ๊ต๊ณผ์„œ ๋ถ„์„ ๊ฒฐ๊ณผ 108 2. ์ดˆ๋“ฑํ•™๊ต 3ยท4ํ•™๋…„๊ตฐ ๊ณผํ•™ ๊ต๊ณผ์„œ ๋ถ„์„ ๊ฒฐ๊ณผ ๋น„๊ต 110 1) ์ถœํŒ์‚ฌ๋ณ„ ๋ถ„์„ ๊ฒฐ๊ณผ ๋น„๊ต 110 2) ํ•ต์‹ฌ ์š”์†Œ ๋ฐ ํ•˜์œ„ ์š”์†Œ๋ณ„ ๋ถ„์„ ๊ฒฐ๊ณผ ๋น„๊ต 121 3) ํ•™๋…„๋ณ„ ๋ถ„์„ ๊ฒฐ๊ณผ ๋น„๊ต 124 ์ œ 3 ์ ˆ ๊ต๊ณผ์„œ ๋ถ„์„ ๊ฒฐ๊ณผ ํ•ด์„ ๋ฐ ๋น„ํŒ์  ํ‰๊ฐ€ 126 1. ๊ต์œก๊ณผ์ • ์„ฑ์ทจ๊ธฐ์ค€ ๋ฐ˜์˜์˜ ์œ ์—ฐ์„ฑ์— ๋Œ€ํ•œ ํ•ด์„ ๋ฐ ํ‰๊ฐ€ 127 2. MCEE ๋‚ด์šฉ ์š”์†Œ ๋ฐ˜์˜์˜ ์ ์ ˆ์„ฑ์— ๋Œ€ํ•œ ํ•ด์„ ๋ฐ ํ‰๊ฐ€ 128 3. MCEE ๋‚ด์šฉ ์š”์†Œ ๋ฐ˜์˜์˜ ๊ฐ€๋Šฅ์„ฑ์— ๋Œ€ํ•œ ํ•ด์„ ๋ฐ ํ‰๊ฐ€ 130 ์ œ 5 ์žฅ ๊ฒฐ๋ก  134 ์ œ 1 ์ ˆ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ ์š”์•ฝ 134 ์ œ 2 ์ ˆ ์—ฐ๊ตฌ์˜ ํ•œ๊ณ„์  137 ์ œ 3 ์ ˆ ๊ณผํ•™๊ต์œก์—์˜ ํ•จ์˜ 140 ์ œ 4 ์ ˆ ๊ณผํ•™๊ต์œก์„ ์œ„ํ•œ ์ œ์–ธ 142 ์ฐธ๊ณ ๋ฌธํ—Œ 145 ๋ถ€๋ก 167 2015 ๊ฐœ์ • ์ค‘ํ•™๊ต ํ™˜๊ฒฝ๊ณผ ๊ต์œก๊ณผ์ • ๋ถ„์„ ๊ฒฐ๊ณผ 167 2015 ๊ฐœ์ • ๊ณ ๋“ฑํ•™๊ต ํ™˜๊ฒฝ๊ณผ ๊ต์œก๊ณผ์ • ๋ถ„์„ ๊ฒฐ๊ณผ 172 ์ „๋ฌธ๊ฐ€ ํƒ€๋‹น๋„ ๊ฒ€์‚ฌ ์˜๋ขฐ์„œ 179 Abstract 207์„

    Factors Associated with Cognitive Function in Breast Cancer Patients Complaining Cognitive Decline

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    Objectives : Cognitive complaints are reported frequently after breast cancer treatments. The causes of cognitive decline are multifactorial, a result of the effect of cancer itself, chemotherapy, and psychological factors such as depression and anxiety. However, cognitive decline does not always correlate with neuropsychological test performance. The purpose of this study was to examine the relationship of subjective cognitive decline with objective measurement and to explore associated factors of cognitive function in breast cancer survivors. Methods : We included 29 breast cancer survivors who complain cognitive decline at least 6 months after treatment and 20 age-matched healthy controls. Neuropsychological tests were performed in all participants. Multivariable regression analysis evaluated associations between neuropsychological test scores and psychological distress including depression and anxiety, also considering age, education, and comorbidity. Results : There were no statistically significant differences in neuropsychological test performances. However, the breast cancer survivors showed a significantly higher depression(p=0.002) and anxiety(p<0.001) than the healthy controls did. Among the cancer survivors, poorer executive function was strongly associated with higher depression(ฮฒ=โˆ’0.336{\beta}=-0.336 ์ˆ˜์‹ ์ด๋ฏธ์ง€, p=0.001) and anxiety(ฮฒ=โˆ’0.273{\beta}=-0.273 ์ˆ˜์‹ ์ด๋ฏธ์ง€, p=0.009), after controlling for age, education, and comorbidity. In addition, poorer attention was also significantly related with depression(ฮฒ=โˆ’0.375{\beta}=-0.375 ์ˆ˜์‹ ์ด๋ฏธ์ง€, p=0.023) and anxiety (ฮฒ=โˆ’0.404{\beta}=-0.404 ์ˆ˜์‹ ์ด๋ฏธ์ง€, p=0.013). Conclusions : The results of this study showed the discrepancies between subjective complaints and objective measures of cognitive function in breast cancer survivors. It suggests that subjective cognitive decline could be indicators of psychological distress such as depression and anxiety.ope

    ์ž์™ธ์„ /ํŽ˜๋†€์— ์˜ํ•ด ์ƒ์„ฑ๋œ ์ˆ˜ํ™”์ „์ž์— ์˜ํ•œ PFOS์˜ ๋ถ„ํ•ด ๋ฐ ๊ณต์กด ๋ฌผ์งˆ์˜ ์˜ํ–ฅ

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    ํ•™์œ„๋…ผ๋ฌธ (์„์‚ฌ)-- ์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› : ๊ณต๊ณผ๋Œ€ํ•™ ๊ฑด์„คํ™˜๊ฒฝ๊ณตํ•™๋ถ€, 2019. 2. ์ตœ์ •๊ถŒ.1900๋…„๋Œ€ ์ค‘๋ฐ˜๋ถ€ํ„ฐ ๊ณผ๋ถˆํ™”ํ™”ํ•ฉ๋ฌผ์˜ ๋„“์€ ์‚ฐ์—…์  ์‚ฌ์šฉ์œผ๋กœ ์ธํ•ด ํ™˜๊ฒฝ ๋งค์งˆ ๋‚ด์˜ ๊ณผ๋ถˆํ™”ํ™”ํ•ฉ๋ฌผ์ด ๋นˆ๋ฒˆํ•˜๊ฒŒ ๊ฒ€์ถœ๋˜๊ณ  ์žˆ๋‹ค. ๊ณผ๋ถˆํ™”ํ™”ํ•ฉ๋ฌผ์€ ํ™˜์›์ „์œ„๊ฐ€ ๋‚ฎ์€ ํƒ„์†Œ-๋ถˆ์†Œ ๊ฒฐํ•ฉ์„ ๋‹ค์ˆ˜ ๊ฐ€์ง€๊ณ  ์žˆ์–ด ๋งค์šฐ ์•ˆ์ •๋˜์–ด ์žˆ์œผ๋ฉฐ ์ž์—ฐ์  ๋ถ„ํ•ด๊ฐ€ ์–ด๋ ค์šด ํŠน์„ฑ ๋•Œ๋ฌธ์—, ์ด์˜ ํšจ๊ณผ์ ์ธ ์ฒ˜๋ฆฌ๊ฐ€ ํ•„์š”ํ•˜๋‹ค. ๊ณผ๋ถˆํ™”ํ™”ํ•ฉ๋ฌผ ์ฒ˜๋ฆฌ ๋ฐฉ์‹ ์ค‘ ๊ด‘๋ถ„ํ•ด ๋ฐฉ์‹์€ ๋„์ž…์ด ๊ฐ„ํŽธํ•˜๋ฉฐ ํƒœ์–‘ ์—๋„ˆ์ง€๋ฅผ ์ด์šฉํ•  ์ˆ˜ ์žˆ๋‹ค. ๋”ฐ๋ผ์„œ, ๊ณผ๋ถˆํ™”ํ™”ํ•ฉ๋ฌผ์˜ ๋ณด๋‹ค ํšจ์œจ์ ์ธ ์ฒ˜๋ฆฌ๋ฅผ ์œ„ํ•ด ๊ด‘๋ถ„ํ•ด ๋ฐฉ์‹์˜ ์—ฐ๊ตฌ๊ฐ€ ๋งŽ์ด ์ง„ํ–‰๋˜์–ด ์™”๋‹ค. ๊ธฐ์กด์˜ ๊ด‘๋ถ„ํ•ด ๋ฐฉ์‹์€ ๋ฌผ์†์— ๋‹ค๋ฅธ ์ฒจ๊ฐ€๋ฌผ์„ ์ฒจ๊ฐ€ํ•˜์—ฌ ์ž์™ธ์„ ์„ ์กฐ์‚ฌ, ์ด์— ๋ฐœ์ƒ๋œ ์ˆ˜ํ™”์ „์ž๋กœ ๊ณผ๋ถˆํ™”ํ™”ํ•ฉ๋ฌผ์„ ๋ถ„ํ•ด์‹œํ‚ค๋Š” ๋ฐฉ์‹์œผ๋กœ ์ด๋ฃจ์–ด์ ธ ์žˆ๋‹ค. ํ•˜์ง€๋งŒ, ์ƒˆ๋กœ ์ฒจ๊ฐ€๋œ ๋ฌผ์งˆ์ด ๋˜ ๋‹ค๋ฅธ ์˜ค์—ผ์›์œผ๋กœ ์ž‘์šฉ๋  ์ˆ˜ ์žˆ๋Š” ๋‹จ์ ์ด ์žˆ๋‹ค. ๋”ฐ๋ผ์„œ ๋ณธ ์—ฐ๊ตฌ๋Š” ๋ฌผ์†์— ๋‹ค๋ฅธ ํ™”ํ•™ ๋ฌผ์งˆ์„ ์ฒจ๊ฐ€ํ•˜์ง€ ์•Š๊ณ  ๊ณผ๋ถˆํ™”ํ™”ํ•ฉ๋ฌผ์„ ์ฒ˜๋ฆฌํ•  ์ˆ˜ ์žˆ๋Š” ๋ฐฉ์‹์„ ๊ณ ์•ˆํ•˜๊ณ , ์ด์˜ ํšจ์œจ์„ฑ์„ ๋ถ„์„ํ•˜๊ณ ์ž ์ˆ˜ํ–‰๋˜์—ˆ๋‹ค. ์ˆ˜ํ™”์ „์ž ๊ณต์—ฌ ๋ฌผ์งˆ๋กœ ๊ธฐ์กด์˜ ์ˆ˜๊ณ„์— ๋„๋ฆฌ ๋ถ„ํฌํ•˜๊ณ  ์žˆ๋Š” ํŽ˜๋†€๋ฅ˜ ๋ฌผ์งˆ์„ ์‚ฌ์šฉํ•˜์˜€์œผ๋ฉฐ, ๋Œ€์ƒ ๊ณผ๋ถˆํ™”ํ™”ํ•ฉ๋ฌผ๋กœ ๋Œ€ํ‘œ์ ์ด๋ฉฐ ๋งŽ์€ ๊ณผ๋ถˆํ™”ํ™”ํ•ฉ๋ฌผ์˜ ์ตœ์ข… ๋Œ€์‚ฌ ์‚ฐ๋ฌผ๋กœ ์•Œ๋ ค์ง„ PFOS (perfluorooctanesulfonic acid)๋ฅผ ์‚ฌ์šฉํ•˜์˜€๋‹ค. ์ฒซ ๋ฒˆ์งธ๋กœ ์ž์™ธ์„ /ํŽ˜๋†€ ๋ฐฉ์‹์œผ๋กœ PFOS๋ฅผ ๋ถ„ํ•ดํ•  ์ˆ˜ ์žˆ๋Š”์ง€ ํ™•์ธํ•˜์˜€๊ณ , ๋‘ ๋ฒˆ์งธ๋กœ ์—ฌ๋Ÿฌ ํŽ˜๋†€๋ฅ˜ ๋ฌผ์งˆ์˜ PFOS ๋ถ„ํ•ด ํšจ์œจ์„ ๋ถ„์„ํ•˜์˜€๋‹ค. ๊ทธ ๊ฒฐ๊ณผ, ์ž์™ธ์„ /ํŽ˜๋†€ ๋ฐฉ์‹์€ PFOS๋ฅผ ๋ถ„ํ•ดํ•  ์ˆ˜ ์žˆ์—ˆ์œผ๋ฉฐ, ์‹คํ—˜์— ์‚ฌ์šฉ๋œ ์—ฌ๋Ÿฌ ํŽ˜๋†€๋ฅ˜ ๋ฌผ์งˆ ์ค‘ ํŽ˜๋†€์ด ๊ฐ€์žฅ ํšจ์œจ์ ์œผ๋กœ PFOS๋ฅผ ๋ถ„ํ•ดํ•  ์ˆ˜ ์žˆ๋Š” ๊ฒƒ์„ ํ™•์ธํ•˜์˜€๋‹ค. ์„ธ ๋ฒˆ์งธ๋กœ, ์—ฌ๋Ÿฌ ๋ฌผ์†์˜ ๊ณต์กด ๋ฌผ์งˆ์ด ์ž์™ธ์„ /ํŽ˜๋†€ ๋ฐฉ์‹์— ๋ฏธ์น˜๋Š” ์˜ํ–ฅ์„ ํ™•์ธํ•˜์˜€๋‹ค. pH๊ฐ€ ๋†’์„์ˆ˜๋ก, ์šฉ์กด ์‚ฐ์†Œ์˜ ๋†๋„๊ฐ€ ๋‚ฎ์„์ˆ˜๋ก, ์งˆ์‚ฐ์—ผ์˜ ๋†๋„๊ฐ€ ๋‚ฎ์„์ˆ˜๋ก, ์œ ๊ธฐ ํƒ„์†Œ์˜ ๋†๋„๊ฐ€ ๋‚ฎ์„์ˆ˜๋ก PFOS๊ฐ€ ๋น ๋ฅด๊ฒŒ ๋ถ„ํ•ด๋˜๋Š” ๊ฒƒ์„ ํ™•์ธํ•˜์˜€์œผ๋ฉฐ ์—ผ์†Œ ์ด์˜จ์˜ ๋†๋„๋Š” ํฐ ์˜ํ–ฅ์„ ๋ฏธ์น˜์ง€ ์•Š๋Š” ๊ฒƒ์„ ํ™•์ธํ•˜์˜€๋‹ค. ๋งˆ์ง€๋ง‰์œผ๋กœ, ์ธ๊ณตํ์ˆ˜ ์œ ์ถœ์ˆ˜ ์กฐ๊ฑด์—์„œ PFOS์˜ ๋ถ„ํ•ด๋ฅผ ํ™•์ธํ•˜์˜€๊ณ , 24์‹œ๊ฐ„ ์ด๋‚ด์— 97% ์ด์ƒ์˜ PFOS๊ฐ€ ๋ถ„ํ•ด๋จ์„ ํ™•์ธํ•˜์˜€๋‹ค. ๋ณธ ์—ฐ๊ตฌ์—์„œ ์‹คํ—˜๋œ ์ž์™ธ์„ /ํŽ˜๋†€ ๋ฐฉ์‹์„ ํ†ตํ•˜์—ฌ PFOS๋ฅผ ๋ถ„ํ•ดํ•  ์ˆ˜ ์žˆ๊ณ , ์ด๋ฅผ ์ ์šฉํ•˜๊ธฐ ์œ„ํ•ด ์—ฌ๋Ÿฌ ๊ฐ€์ง€ ์š”์ธ๋“ค์ด ๋ฏธ์น˜๋Š” ์˜ํ–ฅ์— ๋Œ€ํ•ด ๋ถ„์„ํ•  ์ˆ˜ ์žˆ์—ˆ๋‹ค. ๋”ฐ๋ผ์„œ, ์ด ๋ฐฉ์‹์˜ ์ง์ ‘์ ์ธ ์ ์šฉ์— ๋Œ€ํ•ด ๋’ท๋ฐ›์นจํ•  ์ˆ˜ ์žˆ์„ ๊ฒƒ์œผ๋กœ ํŒ๋‹จ๋œ๋‹ค.Since mid-1900s, perfluorinated compounds has frequently detected in environmental media due to its broad industrial use. Perfluorinated compounds are highly stable because it has a large number of carbon-fluorine bonds with a low reduction potential and is difficult to decompose. Therefore, its effective treatment is required. Of the perfluorinated compound treatment methods, the photolysis method is easy to introduce and there is a possibility to use solar energy. Therefore, many researches on photolysis methods have been conducted for more efficient treatment of perfluorinated compounds. Conventional photolysis methods consist of adding other additives in water like iodide and decomposing perfluorinated compounds by the generated hydrated electrons. However, there is a drawback that newly added material can act as another source of contamination. Therefore, this study was conducted to analyze the effectiveness of the method for treating perfluorinated compounds without adding other chemicals to the water. We used PFOS(perfluorooctanesulfonic acid), which is known as the final metabolite of perfluorinated compound and representative perfluorinated compound. First, it was confirmed that PFOS could be decomposed by UV/phenol method. Second, PFOS decomposition efficiency of various phenolic compounds was analyzed. As a result, UV/phenol method was able to decompose PFOS, and among the various phenolic compounds used in the experiment, it was confirmed that phenol can decompose PFOS most efficiently. Third, the effects of water constituents on UV/phenol system were examined. It was confirmed that PFOS was decomposed rapidly as the pH was higher, the concentration of dissolved oxygen was lower, the concentration of nitrate was lower, the concentration of organic carbon was lower, and the concentration of chlorine ion did not have a significant effect. Finally, the decomposition of PFOS was confirmed under synthetic wastewater effluent conditions and over 97% of PFOS was decomposed within 24 hours. PFOS can be decomposed by the UV/phenol method, and the effects of various factors on the application of PFOS were analyzed. Therefore, we can support the direct application of this method.์ œ 1 ์žฅ ์„œ๋ก  1 ์ œ 1 ์ ˆ ์—ฐ๊ตฌ์˜ ๋ฐฐ๊ฒฝ 1 ์ œ 2 ์ ˆ ์—ฐ๊ตฌ์˜ ๋ชฉ์  5 ์ œ 3 ์ ˆ ์—ฐ๊ตฌ์˜ ๋ฒ”์œ„ 6 ์ œ 2 ์žฅ ๋ฌธํ—Œ ์—ฐ๊ตฌ 7 ์ œ 1 ์ ˆ ๊ณผ๋ถˆํ™”ํ™”ํ•ฉ๋ฌผ 7 1. ๊ณผ๋ถˆํ™”ํ™”ํ•ฉ๋ฌผ์˜ ํŠน์„ฑ ๋ฐ ์œ ํ•ด์„ฑ 7 2. ๊ธฐ์กด ๊ณผ๋ถˆํ™”ํ™”ํ•ฉ๋ฌผ ์ฒ˜๋ฆฌ ๋ฐฉ์‹ 9 ์ œ 2 ์ ˆ ๊ด‘ํ™˜์›(Photoreduction) 11 1. ๊ด‘ํ™”ํ•™์  ๋ฐฉ์‹์˜ ์ด์  11 2. ๊ณ ๋„ ํ™˜์› ๊ณต์ • 12 ์ œ 3 ์žฅ ์‹คํ—˜์žฌ๋ฃŒ ๋ฐ ๋ฐฉ๋ฒ• 15 ์ œ 1 ์ ˆ ์‹คํ—˜ ์žฌ๋ฃŒ 15 1. PFOS(Perfluorooctanesulfonic acid, ๊ณผ๋ถˆํ™”์˜ฅํƒ„์ˆ ํฐ์‚ฐ) 15 2. ํŽ˜๋†€๋ฅ˜ ๋ฌผ์งˆ 16 3. ๊ธฐํƒ€ ์‹คํ—˜ ์žฌ๋ฃŒ 18 ์ œ 2 ์ ˆ PFOS ์ •๋Ÿ‰๋ถ„์„ ๋ฐฉ๋ฒ• 19 ์ œ 3 ์ ˆ ๊ด‘๋ถ„ํ•ด ์‹คํ—˜ 21 ์ œ 4 ์žฅ ์‹คํ—˜๊ฒฐ๊ณผ ๋ฐ ๋ถ„์„ 24 ์ œ 1 ์ ˆ ํŽ˜๋†€ ๋†๋„์— ๋”ฐ๋ฅธ PFOS ๊ด‘๋ถ„ํ•ด 24 ์ œ 2 ์ ˆ ํŽ˜๋†€๋ฅ˜ ๋ฌผ์งˆ์— ๋”ฐ๋ฅธ PFOS ๊ด‘๋ถ„ํ•ด 26 ์ œ 3 ์ ˆ pH์— ๋”ฐ๋ฅธ PFOS ๊ด‘๋ถ„ํ•ด 29 ์ œ 4 ์ ˆ ์Œ์ด์˜จ ๋†๋„์— ๋”ฐ๋ฅธ PFOS ๊ด‘๋ถ„ํ•ด 32 ์ œ 5 ์ ˆ NOM ๋†๋„์— ๋”ฐ๋ฅธ PFOS ๊ด‘๋ถ„ํ•ด 35 ์ œ 6 ์ ˆ ์šฉ์กด์‚ฐ์†Œ ๋†๋„์— ๋”ฐ๋ฅธ PFOS ๊ด‘๋ถ„ํ•ด 37 ์ œ 7 ์ ˆ ์ธ๊ณตํ์ˆ˜ ์กฐ๊ฑด์—์„œ์˜ PFOS ๊ด‘๋ถ„ํ•ด 39 ์ œ 5 ์žฅ ๊ฒฐ๋ก  40 ์ฐธ๊ณ ๋ฌธํ—Œ 42 Abstract 48Maste

    Validation of the Korean version of Center for Epidemiologic Studies Depression Scale-Revised(K-CESD-R)

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    Objectives : The Center for Epidemiologic Studies Depression scale-Revised is a recently revised scale which has been reported as a valid tool for the assessment of depressive symptoms. It encompasses cardinal symptoms of depression described in the Diagnostic and Statistical Manual of Mental disorders, fourth edition. In this study, we assessed the reliability, validity and psychometric properties of the Korean version of the CESD-R(K-CESD-R). Methods : Forty-eight patients diagnosed as major depressive disorder, dysthymia, depressive disorder NOS according to the DSM-IV criteria using Mini International Neuropsychiatric Interview and 48 healthy controls were enrolled in this study. They were assessed with K-CESD-R, K-MADRS, PHQ-9, KQIDS-SR, STAI to check cross-validation. Statistical analyses were performed using calculation of Cronbach's alpha, Pearson correlation coefficient, Principal Component Analysis, ROC curve and optimal cut-off value. Results : The Cronbach's alpha of K-CESD-R was 0.98. The total score of K-CESD-R revealed significantly high correlations with those of K-MADRS, PHQ-9, KQIDS-SR(r=0.910, 0.966 and 0.920, p<0.001, respectively). Factor analysis showed two factors account for 76.29% of total variance. We suggested the optimal cut-off value of K-CESD-R as 13 according to analysis of the ROC curve which value sensitivity and specificity both equally. Conclusions : These Results showed that the K-CESD-R could be a reliable and valid scale to assess depressive symptoms. The K-CESD-R is expected as a useful and effective tool for screening and measuring depressive symptoms not only in outpatient clinic but also epidemiologic studies.ope

    A Validation Study of the Korean-Version of the Personal and Social Performance Scale

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    Objective๏ผšPersonal and social performance scale (PSP) has been reported as useful tool for the assessment of functioning in the psychiatric population. The authors wanted to assess the reliability and validity of the Korean version of the PSP (K-PSP). Methods๏ผšOne hundred ten patients, including out-patients and in-patients, diagnosed as schizophrenia and schizoaffective disorder according to the DSM-IV criteria were participated in the study. Subjects were assessed with K-PSP, Positive and negative syndrome scale (PANSS), Global assessment functioning scale (GAF),and Clinical global impression-severity (CGI-S) to evaluate cross-validation. Statistical analysis was done by the calculation of Cronbachโ€™s alpha, Pearson correlation coefficient. Resutls๏ผšThe Cronbachโ€™s alpha coefficient of K-PSP was 0.79. The correlations of each domain of K-PSP with the total score of K-PSP were statistically significant (r= -0.46~-0.84, p๏ผœ0.001). The inter-rater reliabilities of the total score of K-PSP was 0.79 (p๏ผœ0.001) and individual score (r=0.775~0.783, p๏ผœ0.001) relatively high. The total score of K-PSP showed a meaningful correlations with those of PANSS (r=-0.60, p๏ผœ0.001), GAF (r=-0.71, p๏ผœ0.001) and CGI-S (r=0.60, p๏ผœ0.001). Conclusion๏ผšThe K-PSP is the useful tool for assessment of functioning in the psychiatric population. So K-PSP can be widely used in the clinical practice and psychiatric studies.ope

    The Reliability and Validity of the Korean Version of Medication Adherence Rating Scale

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    Objective : Finding out patientโ€™s non-adherence to medication is an important work for treating schizophrenia. The Medication Adherence Rating Scale is a self-report form, which can simply measure medication adherence in psychosis. We evaluated the reliability and validity of the Korean version of Medication Adherence Rating Scale (KMARS). Methods : Eighty-one individuals with schizophrenia completed the self-administered questionnaires including KMARS, Brief Adherence Rating Scale (BARS), Korean version of Drug Attitude Inventory-10 (KDAI-10) and Korean version of Medication Adherence Questionnaire (KMAQ). Psychometric properties of the KMARS were analyzed. Results : The KMARS has an acceptable internal consistency (ฮฑ=0.71). The KMARS total scores are moderately correlated with BARS (r=0.44, p<0.01), KDAI-10 (r=0.55, p<0.01) and KMAQ (r=0.62, p<0.01). As the result of factor analysis, the structure of the KMARS is different from original scale, but the KMARS can assess not only adherence behavior but also subjective response to medication. Among the questions item 5, โ€œI take my medication only when I am sickโ€, should be used carefully, because it has ambiguous meaning in Korean. Conclusion : KMARS is a simple and reliable tool for measuring medication adherence in psychosis.ope

    T.O.V.A. PROFILES OF CLINICALLY REFERRED CHILDREN WITH SYMPTOMS OF INATTENTION

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    Objective๏ผšThis study aims to investigate the cognitive characteristics of clinically referred children with symptoms of inattention, cach as having ADHD, tic disorder, and emotional disorder. Methods๏ผš65 boys(38 with ADHD, 17 with Tic disorder, and 10 with Emotional disorder) were individually assessed using the KEDI-WISC(FIQ, VIQ, PIQ) and T.O.V.A.(errors of omission, errors of commission, reaction time, variability, anticipatory response, multiple response), and the results of those tests were analyzed. Results๏ผšThere was significant difference among three diagnostic groups of the VIQ of KEDIWISC and the reaction time of T.O.V.A. after the correction of the effect of age difference. Conclusion๏ผšThe findings suggest that the reaction time of T.O.V.A. might be the useful variable to differentiate the ADHD from other psychiatric disorders and the effect of age and IQ difference should be considered carefully to diagnose in clinical setting.ope

    The Clinical Approaches to Learning Disorder for Primary Physicians

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    It is not uncommon for children and adolescents with learning disabilities to have neurologically based disorders and other associated psychosocial problems. Those children have learning disorder need systematic psychiatric and neuropsychological evaluations for proper managements. Moreover many educational test instruments and special educational literatures use an information processing model for understanding learning and learning disabilities. Any learning disorders can involve more than one area in various dysfunctional processes; input disabilities (visual and auditory perceptions, and other sensory integrations), integration disabilities (sequencing, abstraction, and organization), memory disabilities, and output disabilities (language and motor). Individuals with learning disability require appropriate interventions, whether they are clinical or educational. They must be screened primarily by family physicians, pediatricians, and psychiatrists, and have psychosocial supports for themselves and their family, and then be referred to child and adolescent psychiatrists for optimal treatment planning and multimodal managements.ope

    [ํŠน๋ณ„๊ฐ•์—ฐ]๋™์•„์‹œ์•„์˜ ๋ฏธ๋ž˜, ์—ญ์‚ฌ๋ถ„์Ÿ์„ ๋„˜์–ด์„œ

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    ๊ณ ๋งˆ๋ฐ” ์บ ํผ์Šค์—์„œ ๋Œ€ํ•™์›์ƒ๋“ค์„ ๋Œ€์ƒ์œผ๋กœ ํ‰์†Œ์— ์ผ๋ณธํ•™์ƒ๋“ค์—๊ฒŒ ํ•˜๊ณ  ์‹ถ์—ˆ๋˜ ์–˜๊ธฐ๋ฅผ ํ•  ์ˆ˜ ์žˆ์—ˆ๋˜ ๊ฒƒ์€ ๋‚˜์—๊ฒŒ ๊ท€์ค‘ํ•œ ๊ธฐํšŒ์˜€๋‹ค. ์ดˆ์ฒญํ•ด ์ฃผ์‹  ๋‹ค์นดํ•˜์‹œ ๋ฐ์“ฐ์•ผ(้ซ˜ๆฉ‹ๅ“ฒไนŸ) ์„ ์ƒ๊ณผ ๋‚˜๊นŒ์ง€๋งˆ ๋‹ค๊นŒํžˆ๋กœ(ไธญๅณถ๏งœๅš) ์„ ์ƒ, ๊ธฐํƒ€๊ฐ€์™€ ์‚ฌ๋ผ์ฝ”(ๅŒ—ๅทๆฑๅญ)์„ ์ƒ, ํžˆ๋ฐ ์ด์‹œ๊ตฌ๋กœ(ใฒใฆ็Ÿณ้ป‘) ์„ ์ƒ ๋„ค ๋ถ„๊ป˜ ๋‹ค์‹œ ํ•œ๋ฒˆ ๊ฐ์‚ฌํ•œ๋‹ค. ์ˆ˜์—… ์ค‘์— ํ•™์ƒ๋“ค์ด ๊ฐ•์˜๋ฅผ ์—ด์‹ฌํžˆ ๋“ฃ๊ณ  ์ง„์ง€ํ•œ ์งˆ๋ฌธ์„ ๋งŽ์ด ํ•ด ์ฃผ์–ด ํฐ ๋ณด๋žŒ์„ ๋Š๊ผˆ๋‹ค. ๋‚ด ๊ฐ•์˜์˜ ์ฃผ์ œ๋Š” UTCP(The University of Tokyo, Center for Philosophy)์˜ ์—ญ์‚ฌ, ๋ฒ•, ํญ๋ ฅ์ด๋ž€ ํ”„๋กœ์ ํŠธ์— ๋งž์ถ”์–ด ๊ทผ๋Œ€ํ•œ์ผ๊ด€๊ณ„์‚ฌ์—์„œ์˜ ๋ฒ•๊ณผ ํญ๋ ฅ์œผ๋กœ ์ •ํ–ˆ์œผ๋ฉฐ, ์ด ๊ฐ•์˜๋ฅผ ํ†ตํ•ด ๊ฐ•์กฐํ•œ ๊ฒƒ์€ ๋‹ค์Œ๊ณผ ๊ฐ™๋‹ค. ์ฆ‰ ์ผ๋ณธ์€ ํ•œ๊ตญ์„ ์‹๋ฏผ์ง€๋กœ ํ†ต์น˜ํ•˜๋Š” ๋™์•ˆ ๊ทผ๋Œ€ํ™” ์‹œ์ผœ ์ฃผ์—ˆ๋‹ค๊ณ  ํ•˜์ง€๋งŒ ์‹ค์ œ๋กœ๋Š” ํ•œ๊ตญ์˜ ์ž๋ ฅ ๊ทผ๋Œ€ํ™”์˜ ๊ธฐํšŒ๋ฅผ ๋ฐ•ํƒˆํ–ˆ๋˜ ๊ฒƒ์ด๋ฉฐ, ํ•œ๊ตญ๋ณ‘ํ•ฉ์— ๋Œ€ํ•ด์„œ๋„ ์ผ๋ณธ์ธก์—์„œ๋Š” ํ•ฉ๋ฒ•์ด๋ž€ ์ฃผ์žฅ์ด ๋งŽ์œผ๋‚˜ ์‹ค์ œ๋กœ๋Š” ์ ˆ์ฐจ์ƒ์˜ ํƒˆ๋ฒ•์ด ์—ฌ๋Ÿฌ ๋ฒˆ ์ €์งˆ๋Ÿฌ์ง€๊ณ  ๋ฌด๋ ฅ์œผ๋กœ ํ•œ๊ตญ์ธก์„ ์œ„ํ˜‘ํ•ด์„œ ์กฐ์•ฝ์„ ๊ฐ•์ œ ์ฒด๊ฒฐํ–ˆ๊ธฐ ๋•Œ๋ฌธ์— ์กฐ์•ฝ ์ž์ฒด๊ฐ€ ์„ฑ๋ฆฝํ•œ ๊ฒƒ์ด๋ผ๊ณ  ๋ณด๊ธฐ ์–ด๋ ค์šด ์ ์ด ๋งŽ๋‹ค๋Š” ๊ฒƒ์„ ์กฐ์•ฝ๋ฌธ ํ•˜๋‚˜ํ•˜๋‚˜๋ฅผ ํ•จ๊ป˜ ๋ณด๋ฉด์„œ ์–˜๊ธฐํ–ˆ๋‹ค
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