Computerized Evaluation of Individual State Modules

A report on the May 22, 1969 meeting of Appalachian Adult Basic Education Demonstration Center held in Lexington, Kentucky compiled by Jude T. Cotter

Fault detection monitor circuit provides ''self-heal capability'' in electronic modules - A concept

Self-checking technique detects defective solid state modules used in electronic test and checkout instrumentation. A ten bit register provides failure monitor and indication for 1023 comparator circuits, and the automatic fault-isolation capability permits the electronic subsystems to be repaired by replacing the defective module

Multimode ergometer system

System overcomes previous ergometer design and calibration problems including inaccurate measurements, large weight, size, and input power requirements, poor heat dissipation, high flammability, and inaccurate calibration. Device consists of lightweight, accurately controlled ergometer, restraint system, and calibration system

Dialogue State Induction Using Neural Latent Variable Models

Dialogue state modules are a useful component in a task-oriented dialogue system. Traditional methods find dialogue states by manually labeling training corpora, upon which neural models are trained. However, the labeling process can be costly, slow, error-prone, and more importantly, cannot cover the vast range of domains in real-world dialogues for customer service. We propose the task of dialogue state induction, building two neural latent variable models that mine dialogue states automatically from unlabeled customer service dialogue records. Results show that the models can effectively find meaningful slots. In addition, equipped with induced dialogue states, a state-of-the-art dialogue system gives better performance compared with not using a dialogue state module.Comment: IJCAI 202

Ultrasensitivity and Fluctuations in the Barkai-Leibler Model of Chemotaxis Receptors in {\it Escherichia coli}

A stochastic version of the Barkai-Leibler model of chemotaxis receptors in {\it E. coli} is studied here to elucidate the effects of intrinsic network noise in their conformational dynamics. It was originally proposed to explain the robust and near-perfect adaptation of {\it E. coli} observed across a wide range of spatially uniform attractant/repellent (ligand) concentrations. A receptor is either active or inactive and can stochastically switch between the two states. Enzyme CheR methylates inactive receptors while CheB demethylates active ones and the probability for it to be active depends on its level of methylation and ligandation. A simple version of the model with two methylation sites per receptor (M=2) shows zero-order ultrasensitivity (ZOU) akin to the classical 2-state model of covalent modification studied by Goldbeter and Koshland (GK). For extremely small and large ligand concentrations, the system reduces to two 2-state GK modules. A quantitative measure of the spontaneous fluctuations in activity (variance) estimated mathematically under linear noise approximation (LNA) is found to peak near the ZOU transition. The variance is a weak, non-monotonic and decreasing functions of ligand and receptor concentrations. Gillespie simulations for M=2 show excellent agreement with analytical results obtained under LNA. Numerical results for M=2, 3 and 4 show ZOU in mean activity; the variance is found to be smaller for larger M. The magnitude of receptor noise deduced from available experimental data is consistent with our predictions. A simple analysis of the downstream signaling pathway shows that this noise is large enough to have a beneficial effect on the motility of the organism. The response of mean receptor activity to small time-dependent changes in the external ligand concentration, computed within linear response theory, is found to have a bilobe form.Comment: Accepted in PLoS On