9,905 research outputs found

    Sprue cutoff tool for molded FCC plugs

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    Sprue removal operation is accomplished by positioning plug on tool bed, adjusting blades, and moving handle down for cutting process. Blades are raised to remove trimmed plug

    Hyposplenism in gastro-intestinal disease

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    The hazards of living without a spleen were recognised by the paediatricians in the early 1960’s when they focussed attention on the syndrome of fulminant sepsis, often due to pneumococcal infection, occurring in young children within the first two years of splenectomy. The danger of post-splenectomy sepsis (PSS) extends into adult life and splenectomised patients remain at risk 10, 20 and even 30 years after the operation. Problems following splenectomy may just be the tip of the iceberg. It is clear that many other diseases are associated with impaired splenic function in the presence of intact spleens.peer-reviewe

    Celiac disease

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    Celiac disease is a chronic intestinal disease caused by intolerance to gluten. It is characterized by immune-mediated enteropathy, associated with maldigestion and malabsorption of most nutrients and vitamins. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes. The main symptoms are: stomach pain, gas, and bloating, diarrhea, weight loss, anemia, edema, bone or joint pain. Prevalence for clinically overt celiac disease varies from 1:270 in Finland to 1:5000 in North America. Since celiac disease can be asymptomatic, most subjects are not diagnosed or they can present with atypical symptoms. Furthermore, severe inflammation of the small bowel can be present without any gastrointestinal symptoms. The diagnosis should be made early since celiac disease causes growth retardation in untreated children and atypical symptoms like infertility or neurological symptoms. Diagnosis requires endoscopy with jejunal biopsy. In addition, tissue-transglutaminase antibodies are important to confirm the diagnosis since there are other diseases which can mimic celiac disease. The exact cause of celiac disease is unknown but is thought to be primarily immune mediated (tissue-transglutaminase autoantigen); often the disease is inherited. Management consists in life long withdrawal of dietary gluten, which leads to significant clinical and histological improvement. However, complete normalization of histology can take years

    Development of plasmonic sensor using gold nanobipyramids for detection of glyphosate based pesticide

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    The development of plasmonic sensor using gold nanobipyramids (GNBPs) as sensing material for detection of glyphosate based pesticide (GBP) has been performed. The GNBPs was synthesised using seed-mediated growth method (SMGM). In the synthesis process, the effect of three different additive acid types which are chloric, sulfuric, and fluoric acid, and its concentration in growth solution were investigated to obtain optimum surface density and aspect ratio of GNBPs. The structure obtained is gold with face-centered cubic (FCC) crystal structure and diffraction peaks at 2θ values of 38.2º and 44.5º, which corresponding to (111) and (200) planes, respectively. The GNBPs have surface density from 5.21±0.44 to 91.46±3.32% and aspect ratio from 2.00±0.02 to 2.76±0.05. It exhibits two resonance peaks at wavelength around 550 and 580 nm, corresponding to transverse surface plasmon resonance (t-SPR) and at wavelength around 720 and 780 nm, corresponding to longitudinal surface plasmon resonance (l-SPR). In sensing study, the changes in the peak position and intensity for both t-SPR and l-SPR, respectively, in de-ionized water (DIW) as reference and glyphosate solutions as target analyte were measured. The presence of glyphosate as low as 1 mg/mL was successfully detected using this sensor. Besides, gold bone nanorods (GBNRs) and gold nanorods (GNRs) have been employed as sensing material and the results show the GNBPs�based plasmonic sensor demonstrate improved sensitivity compared to other sensors. For t-SPR band, the GNBPs provided sensitivity factor as high as 4.76 and 5.17 times larger than the sensitivity factor of GBNRs and GNRs, while for l-SPR band, the sensitivity factor of GNBPs are 2.87 times larger than GBNRs and 1.57 times larger than GNRs. Also, the selectivity of GNBPs-based plasmonic sensor towards glyphosate is higher than its response to four different analytes, ie. chlorpyrifos, acetic acid and acetone. As a conclusion, the additive acid types and concentrations influenced the morphological of GNBPs and the implementation as a sensing vi material in plasmonic sensor has been proven improved the sensitivity and has good selectivity towards glyphosate

    Use of additive manufacturing on models for sand casting process

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    Casting is a forming process based on material pouring in liquid state. Heat is applied to melt the material from its solid state and pour it in a mold previously constructed to obtain the desired shape after letting it cool. Molds can be permanent or expendable. In sand casting processes, the mold is manufactured from a model that usually is extracted before pouring the melted material (Figure 1). To obtain the part, the sand model needs to be destroyed. Notwithstanding, the sand can be reused several times for new molds. Several elements are needed to obtain a part by a sand casting process: permanent patterns, flasks (cope and drag), gating system (pouring cup, sprue, risers and feeding channels) and cores (only if it is needed). The aim of this work is the manufacturing of some of these elements by additive manufacturing process. The equipment will be used for the practical activities (Figure 1) that currently take place on the subjects where this topic is taught, in the different Degrees in Industrial Engineering at the University of Malaga.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

    PENGALAMAN PENGGUNA DALAM RANCANGAN APLIKASI PEMESANAN TIKET KERETA API MYTRAIN MENGGUNAKAN PENDEKATAN METODE UX JOURNEY

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    Problem: User experience (UX) has become a major focus in modern application design. In the context of ordering train tickets, the My Train application has implemented the UX Journey method approach to improve the quality of services provided to users. This research aims to explore the user experience in using the My Train application and evaluate the effectiveness of the UX Journey approach in improving the user experience. The discussion of the problem is how implementing UX Journey affects the user experience in the My Train application. The research method used is a qualitative approach with data collection through in-depth interviews with users who have used the My Train application. Method: In this method, researchers explore users' views and experiences in interacting with the application. We also seek a deep understanding of the challenges they face and the extent to which the UX Journey approach has provided solutions. Results: The research results show that applying the UX Journey approach to the My Train application has had a positive impact on the user experience. Users reported significant improvements in terms of easier navigation, clearer information, and a more efficient ordering process. Although there were several challenges, such as understanding new features and system response speed, improvements made based on user feedback have provided a satisfactory solution. Conclusion and development: It is hoped that the UX Journey approach can effectively improve the user experience in the My Train application. This provides valuable insights for the development of better services and can be adopted by similar applications in an effort to improve user experience. Furthermore, this research also opens up the potential for further development in the context of the UX Journey which can be applied in various industries and applications

    Who witnesses The Witness? Finding witnesses in The Witness is hard and sometimes impossible

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    We analyze the computational complexity of the many types of pencil-and-paper-style puzzles featured in the 2016 puzzle video game The Witness. In all puzzles, the goal is to draw a simple path in a rectangular grid graph from a start vertex to a destination vertex. The different puzzle types place different constraints on the path: preventing some edges from being visited (broken edges); forcing some edges or vertices to be visited (hexagons); forcing some cells to have certain numbers of incident path edges (triangles); or forcing the regions formed by the path to be partially monochromatic (squares), have exactly two special cells (stars), or be singly covered by given shapes (polyominoes) and/or negatively counting shapes (antipolyominoes). We show that any one of these clue types (except the first) is enough to make path finding NP-complete ("witnesses exist but are hard to find"), even for rectangular boards. Furthermore, we show that a final clue type (antibody), which necessarily "cancels" the effect of another clue in the same region, makes path finding Σ2\Sigma_2-complete ("witnesses do not exist"), even with a single antibody (combined with many anti/polyominoes), and the problem gets no harder with many antibodies. On the positive side, we give a polynomial-time algorithm for monomino clues, by reducing to hexagon clues on the boundary of the puzzle, even in the presence of broken edges, and solving "subset Hamiltonian path" for terminals on the boundary of an embedded planar graph in polynomial time.Comment: 72 pages, 59 figures. Revised proof of Lemma 3.5. A short version of this paper appeared at the 9th International Conference on Fun with Algorithms (FUN 2018
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