Developing an Animal Model of Single Sided Deafness (SSD)

HonorsNeuroscienceUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/162662/1/rmjawad.pd

Bone conductive implants in single sided deafness

Conclusion: The Bone Conductive Implants (BCI) showed to partly restore some of the functions lost when the binaural hearing is missing, such as in the single-sided deafness (SSD) subjects. The adoption of the single BCI needs to be advised by the clinician on the ground of a thorough counselling with the SSD subject. Objectives: To perform an overview of the present possibilities of BCI in SSD and to evaluate the reliability of the audiological evaluation for assessing the speech recognition in noise and the sound localization cues, as major problems related to the loss of binaural hearing. Method: Nine SSD subjects who underwent BCI implantation underwent a pre-operative audiological evaluation, consisting in the soundfield speech audiometry, as word recognition score (WRS) and sound localization, in quiet and in noise. Moreover, they were also tested for the accuracy of directional word recognition in noise and with the subjective evaluation with APHAB questionnaire. Results: The mean maximum percentage of word discrimination was 65.5% in the unaided condition and 78.9% in the BCI condition. The sound localization in noise with the BCI was better than the unaided condition, especially when stimulus and noise were on the same side of the implanted ear. The accuracy of directional word recognition showed to improve with BCI in respect to the unaided condition, in the BCI side, with either the stimulus on the implanted ear and the noise in the contralateral ear, or when both stimulus and noise were deliver to implanted ear

Transitions in auditory rehabilitation with bone conductive implant (bci)

Background: The bone conductive implants (BCI) are nowadays a reliable alternative for rehabilitation of specific forms of hearing loss, i.e. conductive, mixed or single sided deafness (SSD). Aims/Objective: To analyse the various factors in play when considering an auditory rehabilitation with a bone-conductive device (BCI). Materials and Methods: The clinical charts of subjects who underwent BCI application at the same Implanting Center from 2005 to 2018 were retrieved analysing also the reason for eventual explantation and the alternative option (transition) for hearing rehabilitation. Results: Nine BAHA Compact, 4 BAHA Intenso, 21 BAHA Divino, 3 BAHA BP100, 4 Ponto, 2 Sophono, 5 Bonebridge, 5 BAHA5 Attract; 11 BAHA5 Connect were used in 12 unilateral COM; 16 bilateral COM; 3 unilateral cholesteatoma; 6 bilateral cholesteatoma; 2 unilateral otosclerosis; 5 bilateral otosclerosis; 9 congenital malformations; 6 major otoneurosurgical procedures; 5 sudden deafness. Explantation was necessary for five subjects. Conclusions: Middle ear pathology and sequels from surgery represent the most common reason for BCI implantation, both in unilateral and in bilateral cases. Transition from one implantable device to another one can be predictable, mostly when explantation is necessary. Significance: The role of BCI for rehabilitation in middle ear pathology may be extremely important

American Cochlear Implant Alliance Task Force guidelines for clinical assessment and management of adult cochlear implantation for single-sided deafness

The indications for cochlear implantation have expanded to include individuals with profound sensorineural hearing loss in the impaired ear and normal hearing (NH) in the contralateral ear, known as single-sided deafness (SSD). There are additional considerations for the clinical assessment and management of adult cochlear implant candidates and recipients with SSD as compared to conventional cochlear implant candidates with bilateral moderate to profound sensorineural hearing loss. The present report reviews the current evidence relevant to the assessment and management of adults with SSD. A systematic review was also conducted on published studies that investigated outcomes of cochlear implant use on measures of speech recognition in quiet and noise, sound source localization, tinnitus perception, and quality of life for this patient population. Expert consensus and systematic review of the current literature were combined to provide guidance for the clinical assessment and management of adults with SSD

Bone conductive implantation in asymmetric hearing loss (AHL)

Background: Bone conductive implants (BCI) represent one possible solution for rehabilitation of single sided deafness (SSD), being able to restore a pseudo-stereophonic hearing when the hearing threshold of the contralateral ear is normal. Objectives: The aim of the present study was to verify the efficacy of bone conduction implantation in subjects with unilateral severe-to-profound hearing loss and contralateral mild-to-moderate hearing loss, i.e. asymmetric hearing loss (AHL), and to compare it with known indications for SSD. Method: Twenty-one subjects, 9 females and 12 males, with a mean age of 55.6 years received BCI for either SSD or AHL. All of the subjects underwent a battery of audiological tests, including free-field pure tone audiometry (PTA) and free-field speech audiometry in quiet and in noise and under unaided and aided conditions. All subjects were administered subjective evaluation tests regarding quality of sound (QoS) and life (QoL), along with 2 questionnaires: the Glasgow Benefit Inventory (GBI) and the General Satisfaction for Bone Anchored Hearing Aids (proposed by the former manufacturer). Data were collected and statistically evaluated within and between the SSD group and the AHL group. Results: A PTA threshold gain was observed in AHL patients. The speech audiometry test in quiet showed an improvement in speech recognition of between 10% and 18% in AHL patients and of less than 10% in SSD patients. The speech audiometry test in noise showed improved values only in AHL patients. The two visual-analogue-scale evaluations (QoL and QoS) and the GBI showed significantly better scores in AHL patients compared to SSD patients

Multicenter Results with an Active Transcutaneous Bone Conduction Implant in Patients with Single-sided Deafness

Objective: To evaluate the audiological and subjective benefit from hearing rehabilitation with an active bone conduction implant in subjects with single-sided sensorineural deafness (SSD). Study design: Prospective, multicenter, single-subject repeated measures. Setting: Tertiary referral center, five clinics in Germany and Switzerland. Patients: Seventeen subjects aged 18 years and older with severe to profound unilateral sensorineural hearing loss and contralateral normal hearing were followed up for 24 months. Intervention: Active bone conduction implant. Main outcome measures: Speech understanding in noise was assessed in three situations: with signal from front, deaf, or normal hearing side (with noise from front in all set-ups). Subjective benefit was evaluated using the Speech, Spatial, and Qualities of Hearing (SSQ-B) and Bern Benefit in Single-Sided Deafness (BBSS) questionnaire. Results: When the signal was coming from the deaf side the mean improvement of the speech reception threshold in noise ranged from 1.5 up to 2.2 dB with the device and was statistically and clinically significant at all tested timepoints. No significant difference between the aided and unaided situation was found when signal and noise were coming from the front. With the signal from the normal hearing side no clinically significant difference, that is, greater than 1 dB between the aided and unaided situation was found. The SSQ-B and BBSS questionnaire showed an overall improvement with no significant difference between time points. Conclusions: The study demonstrates long-term efficacy and benefit of the device in adults with SSD. Patients reported substantial and persistent subjective benefit from the active bone conduction implant

Cochlear Implant in Single-Sided Deafness Children and Adults

Binaural hearing in humans ensures our effective communication as it improves the sound localization, the speech understanding in noise, the spatial awareness, the listening easiness, and the development of spoken language. The majority of the literature on patients with single-sided deafness and cochlear implantation involves adult patients; the cochlear implant is a viable and cost-effective treatment option for this population. So in this chapter, we will emphasize the importance of early treatment of unilateral hearing loss in the pediatric age and the emerging indication of the cochlear implant as a treatment

청각신경종양 제거술 후 발생한 일측 청력저하 환자들에서 Baha Attract를 이용한 청각재활 효과

Background : Single-sided deafness (SSD) is defined as a unilateral sensorineural deafness in the poorer ear, and vestibular schwannoma itself, or treatment of it can cause patients SSD. So there were many treatments for SSD, such as hearing aids, bone-anchored hearing devices, but which had many disadvantages. Now newly developed system, Baha Attract have some advantages. Methods : As a case series study, retrospective chart review was conducted for 4 patients who had undergone Baha Attract implantation after removal of vestibular schwannoma for rehabilitation of SSD by one senior surgeon (M.I.S.) at a single tertiary hospital in 2021. We analyzed the clinical features, radiologic findings (computed tomography [CT], magnetic resonance imaging [MRI]), hearing tests (pure tone audiogram), and surgical outcomes of the patients. Results : All patient took postoperative temporal MRI of schwannoma removal, temporal bone CT, pure tone audiogram. During 2-5 months outpatient follow-up, of course there should be further long period observation, we concluded there were some advantages of patient’s hearing level. Conclusions : There should be a lot of further studies in Baha Attract implant model, it can be one of useful treatments for SSD patients to improve hearing levelsope

Auditory Cortical Plasticity in Patients with Single-Sided Deafness Before and After Cochlear Implantation

PURPOSE This study investigated neuroplastic changes induced by postlingual single-sided deafness (SSD) and the effects of a cochlear implantation for the deaf ear. Neural processing of acoustic signals from the normal hearing ear to the brain was studied before and after implantation using a positron emission tomography (PET)/CT scanner. METHODS Eight patients with postlingual SSD received a cochlear implant (CI) in a prospective clinical trial. Dynamic imaging was performed in a PET/CT scanner using radioactively labeled water ([15O]H2O) to localize changes in the regional cerebral blood flow (rCBF) with and without an auditory task of logatomes containing speech-like elements without meaningful context. The normal hearing ear was stimulated before implantation and after the use of the cochlear implant for at least 8 months (mean 13.5, range 8.1-26.6). Eight age- and gender-matched subjects with normal hearing on both sides served as healthy control subjects (HCS). RESULTS When the normal hearing ear of SSD patients was stimulated before CI implantation, the [15O]H2O-PET showed a more symmetrical rCBF in the auditory regions of both hemispheres in comparison to the HCS. The use of CI increased the asymmetry index (AI) in six of eight patients indicating an increase of activity of the contralateral hemisphere. Non-parametric statistics revealed a significant difference in the AI between patients before CI implantation and HCS (p < .01), which disappeared after CI implantation (p = .195). CONCLUSION The functional neuroimaging data showed a tendency towards normalization of neuronal activity after CI implantation, which supports the effectiveness of CI in SSD patients. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT01749592, December 13, 2012