Mahasiswa Diseru Terokai Bidang Keusahawanan

USM KUBANG KERIAN, 11 Mac 2018 – “Mahasiswa yang masih lagi melanjutkan pelajaran di Institusi Pengajian Tinggi (IPT) digalakkan menceburi bidang keusahawanan walaupun masih bergelar pelajar”, demikian perkongsian Pengerusi Koperasi Ko-Ummah yang juga Alumni Universiti Sains Malaysia (USM), Luqman Nurhakim Perma Suria

The Small Molecule Dispergo Tubulates the Endoplasmic Reticulum and Inhibits Export

The mammalian endoplasmic reticulum (ER) is an organelle that maintains a complex, compartmentalized organization of interconnected cisternae and tubules while supporting a continuous flow of newly synthesized proteins and lipids to the Golgi apparatus. Using a phenotypic screen, we identify a small molecule, dispergo, that induces reversible loss of the ER cisternae and extensive ER tubulation, including formation of ER patches comprising densely packed tubules. Dispergo also prevents export from the ER to the Golgi apparatus, and this traffic block results in breakdown of the Golgi apparatus, primarily due to maintenance of the constitutive retrograde transport of its components to the ER. The effects of dispergo are reversible, since its removal allows recovery of the ER cisternae at the expense of the densely packed tubular ER patches. This recovery occurs together with reactivation of ER-to-Golgi traffic and regeneration of a functional Golgi with correct morphology. Because dispergo is the first small molecule that reversibly tubulates the ER and inhibits its export function, it will be useful in studying these complex processes.Chemistry and Chemical Biolog

Optical control of ground-state atomic orbital alignment: Cl(P-2(3/2)) atoms from HCl(v=2,J=1) photodissociation

H(35)Cl(v=0,J=0) molecules in a supersonic expansion were excited to the H(35)Cl(v=2,J=1,M=0) state with linearly polarized laser pulses at about 1.7 microm. These rotationally aligned J=1 molecules were then selectively photodissociated with a linearly polarized laser pulse at 220 nm after a time delay, and the velocity-dependent alignment of the (35)Cl((2)P(32)) photofragments was measured using 2+1 REMPI and time-of-flight mass spectrometry. The (35)Cl((2)P(32)) atoms are aligned by two mechanisms: (1) the time-dependent transfer of rotational polarization of the H(35)Cl(v=2,J=1,M=0) molecule to the (35)Cl((2)P(32)) nuclear spin which is conserved during the photodissociation and thus contributes to the total (35)Cl((2)P(32)) photofragment atomic polarization] and (2) the alignment of the (35)Cl((2)P(32)) electronic polarization resulting from the photoexcitation and dissociation process. The total alignment of the (35)Cl((2)P(32)) photofragments from these two mechanisms was found to vary as a function of time delay between the excitation and the photolysis laser pulses, in agreement with theoretical predictions. We show that the alignment of the ground-state (35)Cl((2)P(32)) atoms, with respect to the photodissociation recoil direction, can be controlled optically. Potential applications include the study of alignment-dependent collision effects

Position-Selected Molecular Ruler

The molecular ruler method allows the precise control of the gap between a parent gold structure and a deposited daughter structure using a conveniently grown self-assembled molecular multilayer as a lithographic mask. However, we cannot choose a position where the gap should be placed, since the ruler attaches to all exposed gold surfaces. In this work, a convenient method of selecting the position of nanogaps by further patterning the molecular multilayer using low-energy electron beam irradiation and piranha etchant is described

Spartanburg Humane Society Data Analysis: Hotspots and Resource Management

A data set from the Spartanburg Humane Society was provided with the hope that the use of GIS could show patterns and hotspots of dog and cat pickup locations. With a better understanding of where the majority of the animals come from, the Humane Society can better distribute their man power and resources to help as many homeless animals as possible. According to Beck (1973) the main reasons for stray and abandoned animals is negligence causing pet releases or escapes, and also breeding. Therefore, finding and targeting areas where there are many strays (potentially as a result of a release, escape, or breeding) is imperative to educating the people there on the importance of overall pet care and spaying or neutering their pets. Other reasons for animal pickups by the Humane Society are listed in the data set and include anything from “moving” to “destructive”. In this study I identified statistically significant hotspots of cat and dog surrenders and strays. The hotspot method was deemed an appropriate process through personal discretion and literature on cluster analysis with crime data. Using spatial relationships, hotspots can show where there is significantly higher animal location concentrations. Papers on crime data by Grubesic & Murray (2001) along with Ratcliffe & McCullagh (1999) discussed different methods for calculating these spatial relationships while taking into account the surrounding urban factors. Since population density is likely to be a contributing factor to the number of animals present in an area, population density was factored into the analysis or normalized to identify hotspots based on factors other than population. Hotspots were also calculated without normalizing for population in order to give the Spartanburg Humane Society a good idea about where most of their animals are coming from despite the number of people there. This will assist in determining the best areas for resource distribution