Effect of Tibetan Compound Wuwei manna bath on langxiu disease

Objective To observe the effect of Tibetan Compound Wuwei manna bath in the treatment of langxiu disease. Methods 96 patients with “langxiu” disease in our hospital from January 2020 to January 2021 were randomly selected for the study, according to the computer random method, 48 cases were divided into a group and group B were treated with Tibetan medicine compound five flavor manna bath. Then the therapeutic effect and adverse reactions of the two groups were compared. Results: after treatment, the treatment effect of group B was better than that of group A, and the incidence of adverse reactions of group B was lower than that of group A. P ＜ 0.05； Conclusion: the patients with langxiu disease were treated with Tibetan medicine compound Wuwei manna bath,It can effectively improve the treatment effect and reduce the occurrence of adverse reactions, which is worthy of wide promotion and application

Application Comparison of Contrast-Enhanced Ultrasound-Guided Microwave Ablation and Traditional Surgery for Benign Breast Nodules

Objective: To analyze the therapeutic effect of contrast-enhanced ultrasound-guided microwave ablation and traditional surgery in the treatment of benign breast nodules. Methods: The research subjects included in this study were 68 patients with benign breast nodules admitted to our hospital from January 2020 to January 2021. They were divided into control group and experimental group by random number table method. The control group received traditional surgical treatment (34 cases), and the experimental group received contrast-enhanced ultrasound-guided microwave ablation (34 cases). The treatment effects of the two groups were compared. Results: There was no significant difference in operation time between the two groups, which did not meet statistical significance (P>0.05). Intraoperative blood loss, incision healing time and pain score were lower in the experimental group than in the experimental group (P<0.05). There were significant differences in postoperative hematoma, scar formation rate and lesion residual rate between the two groups, among which the experimental group was lower (P<0.05). Conclusion: Contrast-enhanced ultrasound-guided microwave ablation and traditional surgery are used in the treatment of benign breast nodules. The former is better than the latter. This treatment method can be promoted

Observation of the Effect of Low Molecular Weight Heparin Calcium Combined with Acetylcysteine in the Treatment of Idiopathic Interstitial Pneumonia

Objective: To analyze the effect of low molecular weight heparin calcium combined with acetylcysteine in the treatment of patients with idiopathic interstitial pneumonia. Methods: The subjects selected for this study were patients with idiopathic interstitial pneumonia admitted to our hospital from June 2020 to June 2021, with a total of 56 cases. They were divided into control group and experimental group by random number table method. The control group was treated with acetylcysteine (28 cases), and the experimental group was treated with low molecular weight heparin calcium on the basis of the control group (28 cases). The treatment effects of the two groups were compared. Results: There were significant differences in the effective rates of treatment between the two groups, and the experimental group was higher (P<0.05). There were significant differences in pulmonary function indexes between the two groups, among which the experimental group was higher (P<0.05). Conclusion: Low molecular weight heparin calcium + acetylcysteine is effective in the treatment of patients with idiopathic interstitial pneumonia, and this combined treatment method can be promoted

Effect of YKL-40 RNA Interference on VEGF Gene Polymorphism Expression in Atherosclerotic Mice

Aims: To investigate the effect of YKL-40 RNA interference on VEGF gene polymorphism expression in atherosclerotic mice. Methods: After the atherosclerosis models in mice were built, the mice were divided into three groups including control group, negative control group and observation group, which were separately given to normal saline, negative virus (5 × 107 TU) and YKL-40 RNA interference lentivirus. Then the whole blood DNA was extracted and genotyped in each group of mice and the expression of VEGF in each group of mice was detected by PCR, while the expression level of inflammatory factors in each group of mice was detected by ELISA. Meanwhile, the aortas of mice in each group were pathologically analyzed and the atherosclerosis of mice was detected. Results: Compared with the control group, the VEGF content in both the virus negative control group and the observation group was significantly increased（P<0.05）. The detection rates of CC genotype and C allele at rs699947 of VEGF gene in the observation group were significantly higher than those in the control group and the virus negative control group, and the difference was statistically significant. There were no significant changes for the expression of HDL-C, LDL-C, TC and TG in mice of each group（P>0.05）. Moreover, the levels of Lp-PLA2 and MCP-1 in the negative control group were significantly increased (P < 0.05), while those in the observation group were significantly decreased (P < 0.05) compared to that in control group. What’s more, the histomorphology of the observation group was significantly different from that of the control group and the virus negative control group. The thickness of the fibrous cap of the as plaque was significantly higher than that of the control group and the virus negative control group, but the plaque area and fat content were significantly lower than that of the control group and the virus negative control group and the NC group. Besides, there was no significant difference in lipid content, fiber cap thickness and plaque area between the control group and the virus negative control group. Conclusion: YKL-40 RNAi could improve the VEGF polymorphism, reduce the expression of LP⁃PLA2 and MCP⁃1, and significantly inhibit the occurrence and development of atherosclerosis, which was expected to provide a new target for the prevention and treatment of atherosclerosis

Application Effect of “3P” Nursing Management Mode in Emergency Patients with Acute Ischemic Stroke

Objective:To explore the application effects of the 3P(perfecting equipment,perfecting nursing ability, perfecting emergency pathway and application) nursing management mode of acute ischemic stroke nursing care. Methods: Clinical data of 80 cases of patients were selected as research group,and 80 acute ischemic stroke patients were selected as reference group. Results: Vein opening time, CT completion time and thrombolysis DNT in the research group were significantly lower than that of the reference group（P < 0.05. Conclusion: The "3P" management mode can significantly shorten the patients' vein opening time, CT completion time and DNT time of thrombolysis, improve the first aid effect,improve the treatment effect of AIS, which can be widely used

Application of Modified POSSUM Scoring System in Patients Undergoing Thoracoscopic Surgery

Objective: To investigate the predictive value of a physiology and surgical severity-based score (POSSUM score) modified according to the characteristics of thoracic surgery for complications and mortality in patients undergoing thoracoscopic surgery. Method: To investigate the value of the modified POSSUM scoring system in predicting the complication and mortality rate of patients undergoing thoracoscopic surgery. The clinical data of 104 patients who underwent thoracic surgery in the Thoracic Surgery Department of Guangzhou Red Cross Hospital between May 2018 and May 2020 were retrospectively analyzed. The modified POSSUM score was used for preoperative patients to predict the number of postoperative complications and deaths, and compared with the actual number of complications and deaths. Result: The number of postoperative complications predicted by the improved POSSUM scoring system was 36, and the actual number of complications was 42. The difference was not statistically significant (P>0.05); The predicted number of postoperative deaths was 8, and the actual number of deaths was 1. The difference was statistically significant (P < 0.05). Conclusion: The modified POSSUM scoring system can be used to predict complications after thoracoscopic surgery but may overpredict postoperative mortality

Research Progress of Breast Tissue Marker Clips and Their Application in Neoadjuvant Therapy for Breast Cancer

Currently, breast cancer being of rapidly increasing incidence rates and as the most commonly diagnosed malignant tumor in breast surgery, has attracted much attention. Neoadjuvant therapy (NAT) has been proved to be beneficial for reducing tumor size and breast-conserving surgery. As a new type of metal localization marker, breast tissue marker clips can be used to precisely locate tumor tissue and improve cure rates. This review focuses on the marker clips and their significance in the diagnosis and treatment of neoadjuvant therapy for breast cancer, hoping to provide more clinical bases for research and promote this technology

Professor Wang Xiaoyan's Experience in Treating Dementia

Dementia is a common Psychiatric disease, especially in the elderly group of high incidence, Professor Wang Xiaoyan thinks that the pathogenesis of this disease is the deficiency of upper qi, Yang qi can not access the brain body, the etiology is divided into two categories, including deficiency syndrome is divided into weak temper, kidney essence deficiency, positive syndrome is divided into phlegm turbidity and upper confusion, Yang Ming dry heat, etc.Clinical patients are mostly mixed with deficiency and reality, need to distinguish the primary and secondary, dialectical treatment, remarkable effect

Advances in the ADAMTS Family in Cardiovascular Disease

Cardiovascular disease is a serious threat to human life and health. The number of people who die from cardiovascular disease is up to 15 million every year, ranking the first cause of all causes of death. ADAMTS family (A Disintegrin and Metalloproteinase With Thrombospondin Motifs, ADAMTSs) are matrix-associated zinc metallopeptidases with secretory function. It has diverse roles in tissue morphogenesis, pathophysiological remodeling, inflammation, and vascular biology. Controlling the structure and function of the Extracellular Matrix (ECM) is the central theme of the biology of ADAMTSs. ADAMTSs mainly play a biological role by regulating the structure and function of extracellular mechanisms, and the abnormal expression or dysfunction of some family members is associated with cardiovascular diseases. ADAMTS family plays an important role in the occurrence and development of various cardiovascular diseases. This paper aims to study the role of ADAMTS family in cardiovascular diseases

Development and Validation of a Predictive Model for the Prognosis of Complications of Supracondylar Fractures of The Humerus in Children

Objective: Informing patient consultations and healthcare choices, clinical predictive models can offer patients tailored projections of the outcome. The most frequent elbow fractures in children are supracondylar humerus fractures, and clinical prediction models were still largely underutilized in these cases. By developing and verifying a prediction model to lower the risk of postoperative problems in children with supracondylar humerus fractures, this research sought to evaluate independent risk variables connected with the incidence of complications of supracondylar humerus fractures in children. Methods: We retrospectively studied 411 children with supracondylar humerus fractures treated surgically at our hospital from 2015 to 2019, and explored the independent risk factors affecting the prognosis of supracondylar humerus fractures in children in the study group using univariate and multifactorial Cox regression analysis, respectively. In addition, a prediction model based on the independent factors was constructed, a nomogram was made and data from the two cohorts were used to verify the feasibility and reliability of the model and visualize the data. Results: Height, older than eight years, weight, nerve damage, fracture type and with joystick technology of the child as independent risk factors influenced the prognosis of pediatric supracondylar humerus fractures in the modeling constructed by the training cohort, respectively. The results of the validation cohort were further screened for older than eight years, nerve injury and fracture type as independent prognostic factors. Conclusions: We were able to construct a predictive model based on a large genuine data sample, and clinical characteristics in this model could be used as independent predictors for reducing the occurrence of postoperative complications in supracondylar fractures. Combining basic vital signs and clinical risk factors into a simple and clear nomogram was more likely to result in the best treatment plan