Average Emissivity Curve of BATSE Gamma-Ray Bursts with Different Intensities

Six intensity groups with ~150 BATSE gamma-ray bursts each are compared using average emissivity curves. Time-stretch factors for each of the dimmer groups are estimated with respect to the brightest group, which serves as the reference, taking into account the systematics of counts-produced noise effects and choice statistics. A stretching/intensity anti-correlation is found with good statistical significance during the average back slopes of bursts. A stretch factor ~2 is found between the 150 dimmest bursts, with peak flux 4.1 ph cm^{-2} s^{-1}. On the other hand, while a trend of increasing stretching factor may exist for rise fronts for burst with decreasing peak flux from >4.1 ph cm^{-2} s^{-1} down to 0.7 ph cm^{-2} s^{-1}, the magnitude of the stretching factor is less than ~ 1.4 and is therefore inconsistent with stretching factor of back slope.Comment: 21 pages, 3 figures. Accepted to Ap

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension.

Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension. We identified a differential role of mammalian target of rapamycin (mTOR) complex 1 and complex 2, two functionally distinct mTOR complexes, in the development of pulmonary hypertension (PH). Inhibition of mTOR complex 1 attenuated the development of PH; however, inhibition of mTOR complex 2 caused spontaneous PH, potentially due to up-regulation of platelet-derived growth factor receptors in pulmonary arterial smooth muscle cells, and compromised the therapeutic effect of the mTOR inhibitors on PH. In addition, we describe a promising therapeutic strategy using combination treatment with the mTOR inhibitors and the platelet-derived growth factor receptor inhibitors on PH and right ventricular hypertrophy. The data from this study provide an important mechanism-based perspective for developing novel therapies for patients with pulmonary arterial hypertension and right heart failure

Effect of Electron-Phonon Coupling on Thermal Transport across Metal-Nonmetal Interface - A Second Look

The effect of electron-phonon (e-ph) coupling on thermal transport across metal-nonmetal interfaces is yet to be completely understood. In this paper, we use a series of molecular dynamics (MD) simulations with e-ph coupling effect included by Langevin dynamics to calculate the thermal conductance at a model metal-nonmetal interface. It is found that while e-ph coupling can present additional thermal resistance on top of the phonon-phonon thermal resistance, it can also make the phonon-phonon thermal conductance larger than the pure phonon transport case. This is because the e-ph interaction can disturb the phonon subsystem and enhance the energy communication between different phonon modes inside the metal. This facilitates redistributing phonon energy into modes that can more easily transfer energy across the interfaces. Compared to the pure phonon thermal conduction, the total thermal conductance with e-ph coupling effect can become either smaller or larger depending on the coupling factor. This result helps clarify the role of e-ph coupling in thermal transport across metal-nonmetal interface

Medium alkalization due to carbon metabolism is largely responsible for inhibition of bacterial growth by Vibrio cholerae supernatants

Vibrio cholerae is the causative agent of the diarrheal disease cholera. Many Vibrio species secrete antimicrobial factors, though the identity of such a factor has not been determined for any V. cholerae strain. Such an antimicrobial factor could be relevant to pathogenesis of cholera, which disrupts the intestinal microbiome. In this study, we investigated the antimicrobial effects of supernatant from 72 hour old cultures of V. cholerae C6706 on Shigella flexneri CFS100. Inhibition of S. flexneri growth was found to be dependent on the alkaline pH of the supernatant. A 1:1 mixture of pH-adjusted supernatant and LB was found to inhibit S. flexneri growth at alkaline but not neutral pH, as was pH-adjusted LB alone. In minimal medium, elevation of supernatant pH by V. cholerae was dependent on nutritional factors, and this elevation of medium pH also correlated with increased S. flexneri growth inhibition. Though medium alkalization in LB is often attributed to amino acid catabolism and the consequent production of ammonia, supplementation of V. cholerae cultures in minimal medium with amino acids had a weaker effect on alkalization and inhibition than did supplementation with selected carbon sources. This suggests that some feature of carbon metabolism causes medium alkalization and the resultant antimicrobial activity. Several V. cholerae mutants in potentially relevant pathways were screened for alkalization and S. flexneri growth inhibition, but none had any effect.Complicating this picture is the finding that V. cholerae grown under microaerobic conditions produce a less alkaline supernatant with stronger S. flexneri growth inhibition. The significance of this is unknown.Molecular Bioscience

Effect of Soil Buffer Capacity on Soil Reaction (pH) Modification and Subsequent Effects on Growth and Nutrient Uptake of Plantanus occidentalis L. Seedlings

The buffer capacity of a soil is a significant factor in determining the longevity of soil reaction (pH) adjustments by aluminum sulfate, Al2(SO4)3, or calcium carbonate, CaCO₂. After 12 weeks the modified pH values of the highly buffered Emory silt loam had changed substantially toward the original pH value of 7.6. Modified pH values for the Groseclose silt loam soil remained essentially unchanged under the same conditions. These differences in soil response to modified soil pH are related to the differences in the percentage of vermiculite chlorite and chlorite in the clay fractions of the two soils. The longevity of soil pH modification is related to total sycamore seedling dry weight and nutrient uptake. Though these components were significantly affected for plants grown in a Groseclose soil, the lack of significant response differences, except at the extremely low pH adjustment (5.21), in the Emory soil suggests a rapid change in modified soil pH toward the original soil pH value. The condition of the seedlings coupled with total dry weight accumulation and foliar nutrient content elimiates acid toxicity as a factor affecting growth and nutrient uptake. Plants grown in the Groseclose soil at pH 4.31 could be the exception

Effect of Soil Buffer Capacity on Soil Reaction (pH) Modification and Subsequent Effects on Growth and Nutrient Uptake of Plantanus occidentalis L. Seedlings

The buffer capacity of a soil is a significant factor in determining the longevity of soil reaction (pH) adjustments by aluminum sulfate, Al2(SO4)3, or calcium carbonate, CaCO₂. After 12 weeks the modified pH values of the highly buffered Emory silt loam had changed substantially toward the original pH value of 7.6. Modified pH values for the Groseclose silt loam soil remained essentially unchanged under the same conditions. These differences in soil response to modified soil pH are related to the differences in the percentage of vermiculite chlorite and chlorite in the clay fractions of the two soils. The longevity of soil pH modification is related to total sycamore seedling dry weight and nutrient uptake. Though these components were significantly affected for plants grown in a Groseclose soil, the lack of significant response differences, except at the extremely low pH adjustment (5.21), in the Emory soil suggests a rapid change in modified soil pH toward the original soil pH value. The condition of the seedlings coupled with total dry weight accumulation and foliar nutrient content elimiates acid toxicity as a factor affecting growth and nutrient uptake. Plants grown in the Groseclose soil at pH 4.31 could be the exception