3 research outputs found
Expanding the spectrum of "mesenchymal" tumors of the central nervous system
: In this review, we summarize the clinical, histopathological, and molecular features of central nervous system (CNS) tumors with BCOR internal tandem duplication, intracranial mesenchymal tumor with FET/CREB fusion, CNS CIC-rearranged sarcomas and primary intracranial sarcoma DICER1-mutant, now included in the 2021 WHO classification of CNS tumors. Possible relationships between tumors occurring in the CNS and their systemic counterparts are discussed
The spectrum of rare central nervous system (CNS) tumors with EWSR1-non-ETS fusions: experience from three pediatric institutions with review of the literature
The group of CNS mesenchymal (non-meningothelial) and primary glial/neuronal tumors in association with EWSR1-non-ETS rearrangements comprises a growing spectrum of entities, mostly reported in isolation with incomplete molecular profiling. Archival files from three pediatric institutions were queried for unusual cases of pediatric (β€21Β years) CNS EWSR1-rearranged tumors confirmed by at least one molecular technique. Extra-axial tumors and cases with a diagnosis of Ewing sarcoma (EWSR1-ETS family fusions) were excluded. Additional studies, including anchored multiplex-PCR with next-generation sequencing and DNA methylation profiling, were performed as needed to determine fusion partner status and brain tumor methylation class, respectively. Five cases (median 17Β years) were identified (M:F of 3:2). Location was parenchymal (nΒ =Β 3) and undetermined (nΒ =Β 2) with topographic distributions including posterior fossa (nΒ =Β 1), frontal (nΒ =Β 1), temporal (nΒ =Β 1), parietal (nΒ =Β 1) and occipital (nΒ =Β 1) lobes. Final designation with fusion findings included desmoplastic small round cell tumor (EWSR1-WT1; nΒ =Β 1) and tumors of uncertain histogenesis (EWSR1-CREM, nΒ =Β 1; EWSR1-CREB1, nΒ =Β 1; EWSR1-PLAGL1, nΒ =Β 1; and EWSR1-PATZ1, nΒ =Β 1). Tumors showed a wide spectrum of morphology and biologic behavior. For EWSR1-CREM, EWSR1-PLAGL1 and EWSR1-PATZ1 tumors, no significant methylation scores were reached in the known brain tumor classes. Available outcome (4/5) was reported as favorable (nΒ =Β 2) and unfavorable (nΒ =Β 2) with a median follow-up of 30 months. In conclusion, we describe five primary EWSR1-non-ETS fused CNS tumors exhibiting morphologic and biologic heterogeneity and we highlight the clinical importance of determining specific fusion partners to improve diagnostic accuracy, treatment and monitoring. Larger prospective clinicopathological and molecular studies are needed to determine the prognostic implications of histotypes, anatomical location, fusion partners, breakpoints and methylation profiles in patients with these rare tumors
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΈΠ»Ρ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΈΠΎΠΌ Π½Π° ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΈ ΡΠ΅ΡΠΈΠ΄ΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π° Π»Π΅ΡΠ΅Π½ΠΈΡ
Introduction. Meningioma is one of the most common central nervous system tumors, accounting for 39.7 % of all primary brain tumors. The tumor originates from arachnoid meningothelial cells and is characterized by a wide range of histological types classified into 15 subtypes. The histological classification of meningiomas allows us to predict meningioma behavior and the risk of disease recurrence, as well as to define treatment strategies. However, clinical outcomes in histological subgroups of patients are often inconsistent with the histological grade of malignancy. Thus, a more reliable method is needed both to determine the histological subtype of the tumor and to predict the clinical course of the disease with the potential for targeted treatment.The purpose of the study was to summarize the available data on the effect of results of the genomic and proteomic tumor analysis on carcinogenesis with the relationship between the mutational changes and noninvasive diagnosis, treatment and the course of the disease.Material and Methods. Literature search was carried out in the PubMed, Elibrary system, publications were included mainly from 2010 to 2023. with the identification of articles by the keyword βgenetic analysis of meningiomasβ and synonyms. 550 articles were found, of which 55 were used to write a literature review.Conclusion. The study of the molecular genetic profile of meningiomas will improve the classification and establish a correlation with MRI data, the course of the disease and prognosis.ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. ΠΠ΅Π½ΠΈΠ½Π³ΠΈΠΎΠΌΠ°, ΠΎΠ΄Π½Π° ΠΈΠ· ΡΠ°ΠΌΡΡ
ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ, ΡΠΎΡΡΠ°Π²Π»ΡΠ΅Ρ 39,7 % Π²ΡΠ΅Ρ
Π²ΡΡΠ²Π»ΡΠ΅ΠΌΡΡ
ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°. ΠΡΡΠΎΡΠ½ΠΈΠΊΠΎΠΌ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΡΡΠΈΡ
Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠ²Π»ΡΡΡΡΡ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΏΠ°ΡΡΠΈΠ½Π½ΠΎΠΉ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΈ. ΠΠ΅Π½ΠΈΠ½Π³ΠΈΠΎΠΌΡ ΠΎΡΠ»ΠΈΡΠ°ΡΡΡΡ ΡΠΈΡΠΎΠΊΠΈΠΌ ΡΠΏΠ΅ΠΊΡΡΠΎΠΌ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ², ΡΡΠΎ Π²ΡΡΠ°ΠΆΠ°Π΅ΡΡΡ Π² Π½Π°Π»ΠΈΡΠΈΠΈ 15 Π³ΠΈΡΡΠΎΠΏΠΎΠ΄ΡΠΈΠΏΠΎΠ². ΠΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΈΠΎΠΌ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡΡ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, ΡΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΡΠΈΡΠΊΠΈ ΡΠ΅ΡΠΈΠ΄ΠΈΠ²Π° ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΡΠ°ΠΊΡΠΈΠΊΡ Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°. ΠΠ΄Π½Π°ΠΊΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΡ
ΠΎΠ΄Ρ Π² Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠ΄Π³ΡΡΠΏΠΏΠ°Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΠ°ΡΡΠΎ ΠΏΡΠΎΡΠΈΠ²ΠΎΡΠ΅ΡΠ°Ρ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π³ΡΠ°Π΄Π°ΡΠΈΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌ Π±ΠΎΠ»Π΅Π΅ Π½Π°Π΄Π΅ΠΆΠ½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΠΊΠ°ΠΊ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ΄ΡΠΈΠΏΠ° ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ, ΡΠ°ΠΊ ΠΈ Π΄Π»Ρ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Ρ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ Π΄Π»Ρ ΡΠ°ΡΠ³Π΅ΡΠ½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΎΠ±ΠΎΠ±ΡΠΈΡΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ° Π³Π΅Π½ΠΎΠΌΠ½ΠΎΠ³ΠΎ ΠΈ ΠΏΡΠΎΡΠ΅ΠΎΠΌΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Π½Π° ΠΊΠ°Π½ΡΠ΅ΡΠΎΠ³Π΅Π½Π΅Π· Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ΠΌ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ Π΄Π°Π½Π½ΡΡ
ΠΌΡΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Ρ Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΎΠΉ, Π»Π΅ΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠΎΠΈΡΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠ»ΡΡ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ PubMed, Elibrary, Π²ΠΊΠ»ΡΡΠ°Π»ΠΈΡΡ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Ρ 2010 ΠΏΠΎ 2023 Π³. Ρ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠ΅ΠΉ ΡΡΠ°ΡΠ΅ΠΉ ΠΏΠΎ ΠΊΠ»ΡΡΠ΅Π²ΠΎΠΌΡ ΡΠ»ΠΎΠ²Ρ Β«Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΌΠ΅Π½ΠΈΠ½Π³ΠΈΠΎΠΌΒ» ΠΈ ΡΠΈΠ½ΠΎΠ½ΠΈΠΌΠ°ΠΌΠΈ. ΠΠ°ΠΉΠ΄Π΅Π½ΠΎ 550 ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ², ΠΈΠ· ΠΊΠΎΡΠΎΡΡΡ
55 ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΎ Π΄Π»Ρ Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±Π·ΠΎΡΠ°. Π ΡΠ΄ ΡΡΠ°ΡΠ΅ΠΉ, ΠΎΠΏΡΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½Π½ΡΡ
ΡΠ°Π½Π΅Π΅ 2010 Π³., ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π΄Π»Ρ ΠΈΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΏΡΠ°Π²ΠΊΠΈ ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π°Ρ
Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ. ΠΠ°Π½Π½ΡΠ΅ ΡΡΠ°ΡΡΠΈ Π½Π΅ Π²ΠΊΠ»ΡΡΠ°Π»ΠΈ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΎ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ Π°ΡΠΏΠ΅ΠΊΡΠ΅ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΡΠΎΠ΄ΠΎΠ»ΠΆΠ΅Π½ΠΈΠ΅ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΈΠ»Ρ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΈΠΎΠΌ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ, ΠΈΠ·ΠΌΠ΅Π½Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ, ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ ΡΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°ΡΡ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΡΡ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌ, ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΡΠΎΡΠΈΠ»Π΅ΠΌ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ, ΡΡΡΡΠΊΡΡΡΠΎΠΉ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΈΠΎΠΌΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π°Π½Π°Π»ΠΈΠ·Π° Π΄Π°Π½Π½ΡΡ
ΠΠ Π’ ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ