1,275,997 research outputs found
A Holistic Approach to Curriculum Design – an example from dietetic practice education
Practice Education is an integral component of all student dietitians’ academic programme. This paper outlines how a holistic, situational model of curriculum design was used to redesign a two-week clinical placement module to facilitate application of theory and development of core professional attributes based on pre-existing learning outcomes. This module is currently a core professional development module for all Human Nutrition and Dietetics BSc and PGDip student
TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.
The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes. We have now characterized the regulatory landscape of embryonic multipotent progenitor cells that give rise to all pancreatic epithelial lineages. Using human embryonic pancreas and embryonic-stem-cell-derived progenitors we identify stage-specific transcripts and associated enhancers, many of which are co-occupied by transcription factors that are essential for pancreas development. We further show that TEAD1, a Hippo signalling effector, is an integral component of the transcription factor combinatorial code of pancreatic progenitor enhancers. TEAD and its coactivator YAP activate key pancreatic signalling mediators and transcription factors, and regulate the expansion of pancreatic progenitors. This work therefore uncovers a central role for TEAD and YAP as signal-responsive regulators of multipotent pancreatic progenitors, and provides a resource for the study of embryonic development of the human pancreas
Medición fisiológica integral de la pobreza crónica profunda y estrategias de políticas sociales para el desarrollo temprano
The methodology of the anthropometric indices of chronic poverty at early stages of human development is reviewed by including the possibility of using wealth or consumption as an alternative to income for the representation of an integral dimension of socioeconomic status as well as remarking the methodological adaptability of the indicator to several anthropometric criteria for growth assessment as an integral dimension of the physiologic status for the next generation of poor. Furthermore, a framework on strategies of generational and agricultural policies is discussed to target long-term human development
Systems integrated human engineering on the Navy's rapid acquisition of manufactured parts/test and integration facility
Human Engineering in many projects is at best a limited support function. In this Navy project the Human Engineering function is an integral component of the systems design and development process. Human Engineering is a member of the systems design organization. This ensures that people considerations are: (1) identified early in the project; (2) accounted for in the specifications; (3) incorporated into the design; and (4) the tested product meets the needs and expectations of the people while meeting the overall systems requirements. The project exemplifies achievements that can be made by the symbiosis between systems designers, engineers and Human Engineering. This approach increases Human Engineering's effectiveness and value to a project because it becomes an accepted, contributing team member. It is an approach to doing Human Engineering that should be considered for most projects. The functional and organizational issues giving this approach strength are described
Applying tropos to socio-technical system design and runtime configuration
Recent trends in Software Engineering have introduced the importance of reconsidering the traditional idea of software design as a socio-tecnical problem, where human agents are integral part of the system along with hardware and software components. Design and runtime support for Socio-Technical Systems (STSs) requires appropriate modeling techniques and
non-traditional infrastructures. Agent-oriented software methodologies are natural solutions to the development of STSs, both humans and technical components are conceptualized and analyzed as part of the same system. In this paper, we illustrate a number of Tropos features that we believe fundamental to support the development and runtime reconfiguration of STSs.
Particularly, we focus on two critical design issues: risk analysis and location variability. We show how they are integrated and used into a planning-based approach to support the designer in evaluating and choosing the best design alternative. Finally, we present a generic framework to develop self-reconfigurable STSs
Software systems engineering: a journey to contemporary agile and beyond, do people matter?
It is fascinating to view the evolution of software systems engineering over the decades. At the first glance, it could be perceived that the various approaches and processes are different. Are they indeed different? This paper will briefly discuss such a journey relating to findings from an empirical study in some organisations in the UK. Some of the issues described in the literature and by practitioners are common across different software system engineering approaches over the time. It can be argued that human-element of software development plays an integral part in the success of software systems development endeavour. After all, software engineering is a human-centric craft. In order to understand such issues, we crossed the discipline to other disciplines in order to adapt theories and principles that will help to better understand and tackle such matter. Other disciplines have well established human related theories and principles that can be useful. From Japanese management philosophies, we have adapted Lean and knowledge management theories. From psychology, we have adapted Emotional Intelligence (EI). With such an interdisciplinary view, some of the issues can be addressed adequately. Which bring the question: is it really the process or the people? The second author will reflect on his experience attending the first SQM conference 25 years ago. The reflection will discuss the evolution of software systems engineering, and what was changed since then, if at all changed
Grateful Cooperation: Cistercian Inspiration for Ecological Ethics
As scholars of world religions search for promising ways of responding to the ecological crisis, the Christian tradition can look for inspiration to Descriptio Positionis Seu Situationis Monasterii Claraevallensis, a twelfth-century description of the site and surroundings of Clairvaux abbey. The text exudes the unnamed author\u27s deep appreciation and gratitude for the cooperative interactivity of human beings, other species, the land, water, and air that assured their mutual sustainability and maintained the site\u27s integrity. This view predates by centuries the efforts of contemporary philosophers to reflect on the human relation to other biota and abiota that constitute ecological systems, to develop ethical principles that can guide human functioning as integral parts of these systems, and to facilitate systematic thinking about sustainable development strategies encouraged by the United Nation\u27s World Commission on Environment and Development
- …
