Exponential stabilization without geometric control

We present examples of exponential stabilization for the damped wave equation on a compact manifold in situations where the geometric control condition is not satisfied. This follows from a dynamical argument involving a topological pressure on a suitable uncontrolled set

Geometric control of myogenic cell fate.

This work combines expertise in stem cell biology and bioengineering to define the system for geometric control of proliferation and differentiation of myogenic progenitor cells. We have created an artificial niche of myogenic progenitor cells, namely, modified extracellular matrix (ECM) substrates with spatially embedded growth or differentiation factors (GF, DF) that predictably direct muscle cell fate in a geometric pattern. Embedded GF and DF signal progenitor cells from specifically defined areas on the ECM successfully competed against culture media for myogenic cell fate determination at a clearly defined boundary. Differentiation of myoblasts into myotubes is induced in growth-promoting medium, myotube formation is delayed in differentiation-promoting medium, and myogenic cells, at different stages of proliferation and differentiation, can be induced to coexist adjacently in identical culture media. This method can be used to identify molecular interactions between cells in different stages of myogenic differentiation, which are likely to be important determinants of tissue repair. The designed ECM niches can be further developed into a vehicle for transplantation of myogenic progenitor cells maintaining their regenerative potential. Additionally, this work may also serve as a general model to engineer synthetic cellular niches to harness the regenerative potential of organ stem cells

Geometric control of bacterial surface accumulation

Controlling and suppressing bacterial accumulation at solid surfaces is essential for preventing biofilm formation and biofouling. Whereas various chemical surface treatments are known to reduce cell accumulation and attachment, the role of complex surface geometries remains less well understood. Here, we report experiments and simulations that explore the effects of locally varying boundary curvature on the scattering and accumulation dynamics of swimming Escherichia coli bacteria in quasi-two-dimensional microfluidic channels. Our experimental and numerical results show that a concave periodic boundary geometry can decrease the average cell concentration at the boundary by more than 50% relative to a flat surface.Comment: 10 pages, 5 figure

Realizations of Real Low-Dimensional Lie Algebras

Using a new powerful technique based on the notion of megaideal, we construct a complete set of inequivalent realizations of real Lie algebras of dimension no greater than four in vector fields on a space of an arbitrary (finite) number of variables. Our classification amends and essentially generalizes earlier works on the subject. Known results on classification of low-dimensional real Lie algebras, their automorphisms, differentiations, ideals, subalgebras and realizations are reviewed.Comment: LaTeX2e, 39 pages. Essentially exetended version. Misprints in Appendix are correcte

The weak Pleijel theorem with geometric control

Let $\Omega\subset \mathbb R^d\,, d\geq 2$, be a bounded open set, and denote by $\lambda\_j(\Omega), j\geq 1$, the eigenvalues of the Dirichlet Laplacian arranged in nondecreasing order, with multiplicities. The weak form of Pleijel's theorem states that the number of eigenvalues $\lambda\_j(\Omega)$, for which there exists an associated eigenfunction with precisely $j$ nodal domains (Courant-sharp eigenvalues), is finite. The purpose of this note is to determine an upper bound for Courant-sharp eigenvalues, expressed in terms of simple geometric invariants of $\Omega$. We will see that this is connected with one of the favorite problems considered by Y. Safarov.Comment: Revised Oct. 12, 2016. To appear in Journal of Spectral Theory 6 (2016