Nuclear receptor regulation gears up another Notch

4 pages, 2 figure.In this perspective we describe examples of crosstalk between nuclear receptors (NRs) and Notch signaling by means of direct functional interactions between components of both pathways. This crosstalk may provide eukaryotic organisms with molecular mechanisms for the coordination of llong-distance endocrine signals with cell-to-cell juxtacrine communication.Our work was funded by the Wellcome Trust (grant 061930), the Association for International Cancer Research (03-098) and Ministerio de Educación y Ciencia (SAF2004-02549).Peer reviewe