Current intergene distance is shown to be consistently the strongest predictor of synteny conservation as expected under a simple null model, and other variables are of lesser importance

Hurst, Laurence D

Poyatos, Juan F

Crossref

PubMed Central

Digital.CSIC

Genome Biology

English

AH: The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes. Genome Res

Categorical Data Analysis 2nd edition.

CO: A single determinant dominates the rate of yeast protein evolution. Mol Biol Evol

Comparative architectures of mammalian and chicken genomes reveal highly variable rates of genomic rearrangements across different lineages. Genome Res

et al.: Transcriptional regulatory networks in Saccharomyces cerevisiae. Science

Evolution of the eukaryotic genome. In The Eukaryotic Genome: Organization and Regulation Edited by: Broda

Evolutionary Genetics 2nd edition.

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science

Genes encoding subunits of stable O mm max m m =

Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network. Genome Res

GM: A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression.

High frequency of inversions during eukaryote gene order evolution.

Highly variable rates of genome rearrangements between hemiascomycetous yeast lineages. PLoS Genet

Hurst LD: Evolution of chromosome organization driven by selection for reduced gene expression noise. Nat Genet

Keeling PJ: Genome compaction and stability in microsporidian intracellular parasites. Curr Biol

KH: Multiple rounds of speciation associated with reciprocal gene loss in polyploid yeasts. Nature

LD: A unification of mosaic structures in the human genome. Hum Mol Genet

LD: Clustering of housekeeping genes provides a unified model of gene order in the human genome. Nat Genet

LD: Co-expressed yeast genes cluster over a long range but are not regularly spaced.

LD: Evidence for co-evolution of gene order and recombination rate. Nat Genet

LD: Is optimal gene order impossible? Trends Genet

MJ: Regional variation in the density of essential genes in mice. PLoS Genet

Pál C: Natural selection promotes the conservation of linkage of co-expressed genes. Trends Genet

Periodic epi-organization of the yeast genome revealed by the distribution of promoter sites.

Petes TD: Inaugural article: Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci USA

Saccharomyces Genome Database provides tools to survey gene expression and functional analysis data. Nucleic Acids Res

Sonnhammer EL: Genomic gene clustering analysis of pathways in eukaryotes. Genome Res

Synteny perturbations between wheat homoeologous chromosomes caused by locus duplications and deletions correlate with recombination rates. Proc Natl Acad Sci USA

Tang H: Regulation of adjacent yeast genes. Trends Genet

The evolutionary dynamics of eukaryotic gene order. Nat Rev Genet

The human transcriptome map: clustering of highly expressed genes in chromosomal domains. Science

Transcription control reprogramming in genetic backup circuits. Nat Genet

Tyers M: Stratus not altocumulus: A new view of the yeast protein interaction network. PLoS Biol

Vitkup D: Expression dynamics of a cellular metabolic network. Mol Syst Biol

Wolfe KH: Birth of a metabolic gene cluster in yeast by adaptive gene relocation. Nat Genet

Wolfe KH: Clusters of coexpressed genes in mammalian genomes are conserved by natural selection. Mol Biol Evol

Wolfe KH: Visualizing syntenic relationships among the hemiascomycetes with the Yeast Gene Order Browser.

The determinants of gene order conservation in yeasts