A Metal-free, Three-component Manifold for the C2-Functionalization of 1-Substituted Imidazoles Operating "On Water"

5 páginas, 2 tablas, 2 esquemas, 3 ecuaciones.-- El PDF es la versión de autor.A metal-free, three-component process for the C2-functionalization of N-alkylated imidazoles is reported The multicomponent manifold operates under ‘on water' conditions through the formation of a water-stable (permanent) nucleophilic imidazole carbene (imidazolium ylide). Whereas the incorporated vinyl ether functionality is a convenient handle for further chemical manipulation of the functionalized heterocycle (complexity generation), the use of water as the reaction media gives it a bonus of added benefits in terms of safety, bench-friendly processing and environmental care.This research was supported by the Spanish Ministerio de Ciencia e Innovación, the European Regional Development Fund (CTQ2008-06806-C02-02), the Spanish MSC ISCIII (RETICS RD06/0020/1046), FUNCIS (REDESFAC PI01/06). F.C.-A thnaks CSIC for a predoctoral JAE grant.Peer reviewe