Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

RNAse A mismatch cleavage analysis of 66 primary human colon tumours reveals a high incidence of K-ras genes with mutations at position 12. No apparent correlation was found between the presence of mutant oncogenes and the degree of invasiveness of the tumours but evidence for ras mutational activation in premalignant tissue was obtained.This work was supported by an NIH grant awarded by tbe Nalional Cancer Institute and by a grant from Toyo Jozo Ltd.Peer reviewe