An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testing

We have developed a device capable of remote triggering and in situ quantification of therapeutic drugs, based on magnetically-responsive hydrogels of poly (N-isopropylacrylamide) and alginate (PNiPAAm). The heating efficiency of these hydrogels measured by their specific power absorption (SPA) values showed that the values between 100 and 300 W/g of the material were high enough to reach the lower critical solution temperature (LCST) of the polymeric matrix within few minutes. The drug release through application of AC magnetic fields could be controlled by time-modulated field pulses in order to deliver the desired amount of drug. Using B12 vitamin as a concept drug, the device was calibrated to measure amounts of drug released as small as 25(2) 109 g, demonstrating the potential of this device for very precise quantitative control of drug release.Fil: Bruvera, Ignacio Javier. Universidad de Zaragoza. Instituto de Nanociencia de Aragón; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; ArgentinaFil: Hernández, R.. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: Mijangos Ugarte, Carmen. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: Goya, Rodolfo Gustavo. Universidad de Zaragoza. Instituto de Nanociencia de Aragón; Españ

An integrated device for magnetically-driven drug release and in situ quantitative measurements: Design, fabrication and testing

We have developed a device capable of remote triggering and in situ quantification of therapeutic drugs, based on magnetically-responsive hydrogels of poly (N-isopropylacrylamide) and alginate (PNiPAAm). The heating efficiency of these hydrogels measured by their specific power absorption (SPA) values showed that the values between 100 and 300 W/g of the material were high enough to reach the lower critical solution temperature (LCST) of the polymeric matrix within few minutes. The drug release through application of AC magnetic fields could be controlled by time-modulated field pulses in order to deliver the desired amount of drug. Using B12 vitamin as a concept drug, the device was calibrated to measure amounts of drug released as small as 25(2) × 10-9 g, demonstrating the potential of this device for very precise quantitative control of drug release.Peer Reviewe