Design of a reverberant chamber for noise exposure experiments with small animals

Previous work on the acoustic design of small reverberant chambers for studies on laboratory animals has paid, in general, more attention to the frequency response at certain points in their interior. These designs aimed to provide a frequency response as flat as possible at the receivers, thus avoiding unpleasant spectral coloration effects. However, an equally important, and frequently neglected, aspect is to set an acoustic field as spatially uniform as possible inside the zone where the animals are to be placed during the exposure to noise. Here, an optimization procedure is described to calculate the proportions of the chamber dimensions that confers the highest sound level with the minimum mean squared deviation averaged in a given area inside the chamber. In addition, new stimuli have been designed with a high-pass filtering and linear with frequency gain. These stimuli were intended to adapt the characteristics of the exposing noise to the rodent hearing spectrum, displaced toward higher frequencies than the hearing frequency band of humans. © 2009 Elsevier Ltd. All rights reserved.This work has been supported by the Spanish Ministry of Education and Science, through Grant TRA2007-68080-C03-02/MODAL to PC and by funds from the Comunidad de Madrid (IV PRICYT IC0530), DIGNA Biotech (Ref. 065510), the CIBERER (U761), MICIN (SAF2008-00470) and the Fundación Investigación Médica Mutua Madrileña (Ref. 20070504) to IVN.Peer Reviewe