Solvent-Free Microwave-Assisted Efficient Synthesis of 4,4-Disubstituted 2-Oxazolines

5 pages, 3 tables.4,4-Disubstituted 2-oxazolines have been synthesized by a microwave-promoted solvent-free direct condensation of carboxylic acids and disubstituted -amino alcohols in good to excellent yields. Zinc oxide is a very good solid support in cases where a Lewis acid is required. The method described herein is a very good, safe, clean, economical, and environmentally friendly alternative to the classical procedures.Part of this work was sponsored from 1993 to 1999 by the French-Cuban cooperation within the framework of the agreement CNRS: MINVEC (ref. 5702). We sincerely thank these organisations for their help. Part of this work was supported by the Spanish Ministerio de Ciencia y Tecnología (PB9820443-C02202), the Canary Islands Consejería de Educación y Ciencia (COFI2000/03) and the FEDER (1SD9720747-C4201). A. L. M. T. Thanks to The Third World Academy of Sciences for an equipment budget (research grant N°94-209 RG/CHE/LA), to Universidad La Laguna for an Intercampus Grant

Solvent-Free Microwave-Assisted Efficient Synthesis of 4,4-Disubstituted 2-Oxazolines

5 pages, 3 tables.4,4-Disubstituted 2-oxazolines have been synthesized by a microwave-promoted solvent-free direct condensation of carboxylic acids and disubstituted -amino alcohols in good to excellent yields. Zinc oxide is a very good solid support in cases where a Lewis acid is required. The method described herein is a very good, safe, clean, economical, and environmentally friendly alternative to the classical procedures.Part of this work was sponsored from 1993 to 1999 by the French-Cuban cooperation within the framework of the agreement CNRS: MINVEC (ref. 5702). We sincerely thank these organisations for their help. Part of this work was supported by the Spanish Ministerio de Ciencia y Tecnología (PB9820443-C02202), the Canary Islands Consejería de Educación y Ciencia (COFI2000/03) and the FEDER (1SD9720747-C4201). A. L. M. T. Thanks to The Third World Academy of Sciences for an equipment budget (research grant N°94-209 RG/CHE/LA), to Universidad La Laguna for an Intercampus Grant