Selective serotonin reuptake inhibitors in the treatment of generalized anxiety disorder

Selective serotonin reuptake inhibitors have proven efficacy in the treatment of panic disorder, obsessive–compulsive disorder, post-traumatic stress disorder and social anxiety disorder. Accumulating data shows that selective serotonin reuptake inhibitor treatment can also be efficacious in patients with generalized anxiety disorder. This review summarizes the findings of randomized controlled trials of selective serotonin reuptake inhibitor treatment for generalized anxiety disorder, examines the strengths and weaknesses of other therapeutic approaches and considers potential new treatments for patients with this chronic and disabling anxiety disorder

Diversity enabling equilibration: disorder and the ground state in artificial spin ice

We report a novel approach to the question of whether and how the ground state can be achieved in square artificial spin ices where frustration is incomplete. We identify two types of disorder: quenched disorder in the island response to fields and disorder in the sequence of driving fields. Numerical simulations show that quenched disorder can lead to final states with lower energy, and disorder in the driving fields always lowers the final energy attained by the system. We use a network picture to understand these two effects: disorder in island responses creates new dynamical pathways, and disorder in driving fields allows more pathways to be followed.Comment: 5 pages, 5 figure

Superconductivity of disordered Dirac fermions

We study the effect of disorder on massless, spinful Dirac fermions in two spatial dimensions with attractive interactions, and show that the combination of disorder and attractive interactions is deadly to the Dirac semimetal phase. First, we derive the zero temperature phase diagram of a clean Dirac fermion system with tunable doping level ({\mu}) and attraction strength (g). We show that it contains two phases: a superconductor and a Dirac semimetal. Then, we show that arbitrarily weak disorder destroys the Dirac semimetal, turning it into a superconductor. We discuss the strength of the superconductivity for both long range and short range disorder. For long range disorder, the superconductivity is exponentially weak in the disorder strength. For short range disorder, a uniform mean field analysis predicts that superconductivity should be doubly exponentially weak in the disorder strength. However, a more careful treatment of mesoscopic fluctuations suggests that locally superconducting puddles should form at a much higher temperature, and should establish global phase coherence at a temperature that is only exponentially small in weak disorder. We also discuss the effect of disorder on the quantum critical point of the clean system, building in the effect of disorder through a replica field theory. We show that disorder is a relevant perturbation to the supersymmetric quantum critical point. We expect that in the presence of attractive interactions, the flow away from the critical point ends up in the superconducting phase, although firm conclusions cannot be drawn since the renormalization group analysis flows to strong coupling. We argue that although we expect the quantum critical point to get buried under a superconducting phase, signatures of the critical point may be visible in the finite temperature quantum critical regime.Comment: Added some discussion, particularly pertaining to proximity effec

The identification and psychological treatment of panic disorder in adolescents: a survey of CAMHS clinicians

Background Panic disorder is experienced by around 1% of adolescents, and has a significant impact on social and academic functioning. Preliminary evidence supports the effectiveness of panic disorder specific treatment in adolescents with panic disorder, however panic disorder may be overlooked in adolescents due to overlapping symptoms with other anxiety disorders and other difficulties being more noticeable to others. The aim of this study was to establish what training National Health Service (NHS) Child and Adolescent Mental Health Services (CAMHS) clinicians have received in psychological therapies and panic disorder and how they identify and treat panic disorder in adolescents. Method CAMHS clinicians from a range of professions (n = 427), who were delivering psychological treatments to children and adolescents with anxiety disorders, participated. They completed a cross-sectional, online survey, including a vignette describing an adolescent with panic disorder, and were asked to identify the main diagnosis or presenting problem. Results Less than half the clinicians (48.6%) identified panic disorder or panic symptoms as the main presenting problem from the vignette. The majority of clinicians suggested CBT would be their treatment approach. However, few identified an evidence-based treatment protocol for working with young people with panic disorder. Almost half the sample had received no training in cognitive behaviour therapy (CBT) and around a fifth had received no training in delivering psychological treatments. Conclusions Only half of CAMHS clinicians identified panic disorder from a vignette and although CBT treatments are widely offered, only a minority of adolescents with panic disorder are receiving treatments developed for, and evaluated with young people with panic disorder. There is a vital need for clinician training, the use of tools that aid identification and the implementation of evidence-based treatments within CAMHS

Deviations from Matthiessen rule and resistivity saturation effects in Gd and Fe

According to earlier first-principles calculations, the spin-disorder contribution to the resistivity of rare-earth metals in the paramagnetic state is strongly underestimated if Matthiessen's rule is assumed to hold. To understand this discrepancy, the resistivity of paramagnetic Fe and Gd is evaluated by taking into account both spin and phonon disorder. Calculations are performed using the supercell approach within the linear muffin-tin orbital method. Phonon disorder is modeled by introducing random displacements of the atomic nuclei, and the results are compared with the case of fictitious Anderson disorder. In both cases the resistivity shows a nonlinear dependence on the square of the disorder potential, which is interpreted as a resistivity saturation effect. This effect is much stronger in Gd than in Fe. The non-linearity makes the phonon and spin-disorder contributions to the resistivity non-additive, and the standard procedure of extracting the spin-disorder resistivity by extrapolation from high temperatures becomes ambiguous. An "apparent" spin-disorder resistivity obtained through such extrapolation is in much better agreement with experiment compared to the results obtained by considering only spin disorder. By analyzing the spectral function of the paramagnetic Gd in the presence of Anderson disorder, the resistivity saturation is explained by the collapse of a large area of the Fermi surface due to the disorder-induced mixing between the electronic and hole sheets.Comment: 9 pages, 7 figure

Strong disorder fixed point in absorbing state phase transitions

The effect of quenched disorder on non-equilibrium phase transitions in the directed percolation universality class is studied by a strong disorder renormalization group approach and by density matrix renormalization group calculations. We show that for sufficiently strong disorder the critical behaviour is controlled by a strong disorder fixed point and in one dimension the critical exponents are conjectured to be exact: \beta=(3-\sqrt{5})/2 and \nu_\perp=2. For disorder strengths outside the attractive region of this fixed point, disorder dependent critical exponents are detected. Existing numerical results in two dimensions can be interpreted within a similar scenario.Comment: final version as accepted for PRL, contains new results in two dimension