Misc. Pub. 99-6

Sausages, one of the oldest forms of processed food, are a means of using and preserving animal trimmings. The hot dog is a specialized sausage. It originated in Germany where it was named “dachshund” sausage because it looked like the popular badger (dachs) hound (hund). The U.S. hot dog originated at the Polo Grounds in New York. Vendors hawked dachshund sausages in buns while a sports cartoonist sketched a barking dachshund nestled warmly in a bun. He labeled the cartoon “hot dog”. Today the hot dog enjoys popularity throughout the world

Effect of screening abdominal ultrasound examination on the decision to pursue advanced diagnostic tests and treatment in dogs with neurologic disease.

BackgroundAbdominal ultrasound examinations (AUS) are commonly performed before advanced neurodiagnostics to screen for diseases that might affect diagnostic plans and prognosis.ObjectivesDescribe the type and frequency of abnormalities found by AUS in dogs presenting with a neurological condition, identify risk factors associated with abnormalities, and evaluate treatment decisions based on findings.AnimalsSeven hundred and fifty-nine hospitalized dogs.MethodsRetrospective study. Medical records of dogs presented from 2007 to 2009 for neurologic disease were searched for signalment, neuroanatomic localization, and AUS findings. Whether dogs had advanced neurodiagnostics and treatment was analyzed.ResultsFifty-eight percent of dogs had abnormal findings on AUS. Probability of abnormalities increased with age (P < 0.001). Nondachshund breeds had higher probability of abnormal AUS than dachshunds (odds ratio [OR] = 1.87). Eleven percent of dogs did not have advanced neurodiagnostics and in 1.3%, this was because of abnormal AUS. Dogs with ultrasonographic abnormalities were less likely than dogs without to have advanced neurodiagnostics (OR = 0.3 [95% confidence interval [CI]: 0.17, 0.52]), however, the probability of performing advanced diagnostics was high regardless of normal (OR = 0.95 [95% CI: 0.92, 0.97]) or abnormal (OR = 0.85 [95% CI: 0.81, 0.88]) AUS. Treatment was more often pursued in small dogs and less often in dogs with brain disease.Conclusions and clinical importanceFindings from screening AUS had a small negative effect on the likelihood of pursuing advanced neurodiagnostics. Although it should be included in the extracranial diagnostic workup in dogs with significant history or physical examination abnormalities, AUS is considered a low-yield diagnostic test in young dogs and dachshunds

FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs.

Chondrodystrophy in dogs is defined by dysplastic, shortened long bones and premature degeneration and calcification of intervertebral discs. Independent genome-wide association analyses for skeletal dysplasia (short limbs) within a single breed (PBonferroni = 0.01) and intervertebral disc disease (IVDD) across breeds (PBonferroni = 4.0 × 10-10) both identified a significant association to the same region on CFA12. Whole genome sequencing identified a highly expressed FGF4 retrogene within this shared region. The FGF4 retrogene segregated with limb length and had an odds ratio of 51.23 (95% CI = 46.69, 56.20) for IVDD. Long bone length in dogs is a unique example of multiple disease-causing retrocopies of the same parental gene in a mammalian species. FGF signaling abnormalities have been associated with skeletal dysplasia in humans, and our findings present opportunities for both selective elimination of a medically and financially devastating disease in dogs and further understanding of the ever-growing complexity of retrogene biology

Expression of Distal-less, dachshund, and optomotor blind in Neanthes arenaceodentata (Annelida, Nereididae) does not support homology of appendage-forming mechanisms across the Bilateria

The similarity in the genetic regulation of arthropod and vertebrate appendage formation has been interpreted as the product of a plesiomorphic gene network that was primitively involved in bilaterian appendage development and co-opted to build appendages (in modern phyla) that are not historically related as structures. Data from lophotrochozoans are needed to clarify the pervasiveness of plesiomorphic appendage forming mechanisms. We assayed the expression of three arthropod and vertebrate limb gene orthologs, Distal-less (Dll), dachshund (dac), and optomotor blind (omb), in direct-developing juveniles of the polychaete Neanthes arenaceodentata. Parapodial Dll expression marks premorphogenetic notopodia and neuropodia, becoming restricted to the bases of notopodial cirri and to ventral portions of neuropodia. In outgrowing cephalic appendages, Dll activity is primarily restricted to proximal domains. Dll expression is also prominent in the brain. dac expression occurs in the brain, nerve cord ganglia, a pair of pharyngeal ganglia, presumed interneurons linking a pair of segmental nerves, and in newly differentiating mesoderm. Domains of omb expression include the brain, nerve cord ganglia, one pair of anterior cirri, presumed precursors of dorsal musculature, and the same pharyngeal ganglia and presumed interneurons that express dac. Contrary to their roles in outgrowing arthropod and vertebrate appendages, Dll, dac, and omb lack comparable expression in Neanthes appendages, implying independent evolution of annelid appendage development. We infer that parapodia and arthropodia are not structurally or mechanistically homologous (but their primordia might be), that Dll’s ancestral bilaterian function was in sensory and central nervous system differentiation, and that locomotory appendages possibly evolved from sensory outgrowths

The retinal determination gene dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie complex

The Drosophila transcriptional co-activator protein Yorkie and its vertebrate orthologs YAP and TAZ are potent oncogenes, whose activity is normally kept in check by the upstream Hippo kinase module. Upon its translocation into the nucleus, Yorkie forms complexes with several tissue-specific DNA-binding partners, which help to define the tissue-specific target genes of Yorkie. In the progenitor cells of the eye imaginal disc, the DNA-binding transcription factor Homothorax is required for Yorkie-promoted proliferation and survival through regulation of the bantam microRNA (miRNA). The transit from proliferating progenitors to cell cycle quiescent precursors is associated with the progressive loss of Homothorax and gain of Dachshund, a nuclear protein related to the Sno/Ski family of co-repressors. We have identified Dachshund as an inhibitor of Homothorax-Yorkie-mediated cell proliferation. Loss of dachshund induces Yorkie-dependent tissue overgrowth. Conversely, overexpressing dachshund inhibits tissue growth, prevents Yorkie or Homothorax-mediated cell proliferation of disc epithelia and restricts the transcriptional activity of the Yorkie-Homothorax complex on the bantam enhancer in Drosophila cells. In addition, Dachshund collaborates with the Decapentaplegic receptor Thickveins to repress Homothorax and Cyclin B expression in quiescent precursors. The antagonistic roles of Homothorax and Dachshund in Yorkie activity, together with their mutual repression, ensure that progenitor and precursor cells are under distinct proliferation regimes. Based on the crucial role of the human dachshund homolog DACH1 in tumorigenesis, our work suggests that DACH1 might prevent cellular transformation by limiting the oncogenic activity of YAP and/or TAZ.Spanish Ministry of Economy and Competitiveness (MINECO), EU Feder Funds: (BFU2012-34324), Consolider 'From Genes to Shape' (MICINN), FCT fellowships: (SFRH/BPD/46983/2008, IF/01031/2012)

Non-restrictive Relative Clauses, Ellipsis and Anaphora

Non-restrictive relative clauses (NRRCs) can modify constituents which undergo `pragmatic enrichment' when they appear in answers to questions. For example, in an interchange like: `A: What did Jo think? B: That you should say nothing, which is surprising.' What B says is surprising is that `Jo thinks ...' On the face of it, this might seem problematic for approaches to NRRCs which assume `syntactic integration' and to support an `orphan' analysis, where NRRCs are combined with purely conceptual representations. In this paper we examine a range of elliptical and anaphoric phenomena, and show that this conclusion is misplaced. In fact, the phenomena argue strongly in favour of a syntactically integrated analysis

Three New Probabilistic Models for Dependency Parsing: An Exploration

After presenting a novel O(n^3) parsing algorithm for dependency grammar, we develop three contrasting ways to stochasticize it. We propose (a) a lexical affinity model where words struggle to modify each other, (b) a sense tagging model where words fluctuate randomly in their selectional preferences, and (c) a generative model where the speaker fleshes out each word's syntactic and conceptual structure without regard to the implications for the hearer. We also give preliminary empirical results from evaluating the three models' parsing performance on annotated Wall Street Journal training text (derived from the Penn Treebank). In these results, the generative (i.e., top-down) model performs significantly better than the others, and does about equally well at assigning part-of-speech tags.Comment: 6 pages, LaTeX 2.09 packaged with 4 .eps files, also uses colap.sty and acl.bs

Simultaneous pyometra and viable puppies’ gestation in a bitch

Here we describe a case of pyometra coexisting with gestation in a 4.5 year-old miniature short-haired Dachshund. The dog exhibited depression, vaginal discharge, polydipsia and dehydration. Ultrasound examination revealed the presence of low to moderate anechoic fluid collection in the left uterine horn. Blood analysis revealed mild neutrophilia with a left shift. Based on these findings a presumptive diagnosis of pyometra was made and the bitch was treated using amoxicillin-clavulanate with dopaminergic agonist (cabergoline). A second ultrasound scan revealed the presence of two gestational vesicles in the right uterine horn that were successfully carried to term. Unusually, while pyometra persisted in the left uterine horn, two viable puppies were delivered by caesarean section from the right uterine horn.Fil: Risso, Analia Lorena. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Hospital Escuela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pellegrino, Francisco Javier. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Hospital Escuela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Corrada, Yanina Alejandra. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Hospital Escuela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin