Cíge¾ - new field of chloropal and common opal

In the open pits in surroudings of village Cígeľ in Prievidza district a new occurance of chloropal and common opal was found. The opal postvulkanic mineralization is related to the vulkanic komplex of the mountain range Vtáčnik. The locality is composed of vulcanic rock and their pyroklastic, represented by particularly by andesite and rhyolit brekcia. The quality of the opals is variable. The resouces of the opals were calculated on the order of hundrens ( XOO ) kg of available materials. Local opals have also another utilization mostly for the individual jewel

The occurence of crystaline kalcit in the open pit in Kremnica - Lúèky

The occurence of crystaline located occuiring in pyroxenic andesite, is situated in the open pit for building materials near to Kremnica in iar n/ Hronom district. Calcit in a paragenesis with quartz creates different (in the form and size). Its genesis is related to the hydrotermal mineralization in the Kremnické vrchy. This locality is of mainly mineralogical - colectors importance

Exceptional and Durable Responses to TDM-1 After Trastuzumab Failure for Breast Cancer Skin Metastases: Potential Implications of an Immunological Sanctuary

Breast Cancer (BC) skin metastases represent a challenging clinical scenario. Although they usually arise when other distant metastases are already present, they may also represent a form of locoregional recurrence (LRR). Systemic therapy in this setting may have a role both in case a radical locoregional approach is unfeasible in order to achieve disease control, and as adjuvant strategy after radical removal of cutaneous lesions, in order to prevent or delay subsequent disease spread. Systemic therapy for HER2+ metastatic BC (MBC) currently relies on anti-HER2 targeted agents. In this context TDM1 is an option in trastuzumab-resistant patients.Here we present 2 cases of isolated skin metastases in patients with HER2+ BC progressing during or early after trastuzumab-based therapy, showing impressive responses to TDM1. We hypothesize that the unique properties of skin immune microenvironment may explain the failure of trastuzumab, which exerts its action also through immunological mechanisms, and the subsequent outlier responses to TDM1, that relies on a partially different mechanism of action

PROGRAM LAYANAN BIMBINGAN KELOMPOK MENGGUNAKAN GROUP EXERCISE UNTUK MENINGKATKAN SELF-ESTEEM REMAJA

Self esteem merupakan nilai yang tertanam dalam diri individu yang menjadi tolak ukur kepantasan sebagai manusia yang didasarkan pada pengakuan diri terhadap perilaku yang dimiliki. Self-esteem, dibentuk oleh tiga aspek, yakni: (1) perasaan dalam memahami diri sendiri (2) perasaan terhadap hidup (3) hubungan dengan orang lain. Tujuan dari penelitian ini yaitu: (1) untuk mengetahui profil self-esteem remaja di LKSA Taman Harapan Muhammadiyah Bandung, (2) meningkatkan self esteem remaja dengan bimbingan kelompok menggunakan teknik group exercise. Desain penelitian menggunakan one group pre test-post test design dengan objek penelitian sebanyak 10 remaja yang berusia 15-17 tahun. Analisis data menggunakan deskriptif persentase dan uji wilcoxon. Setelah dilakukan intervensidan berdasar hasil uji Wilcoxon diketahui ke-10 remaja mengalami peningkatan yang cukup signifikan dimana terdapat perbedaan antara self esteem remaja sebelum dan setelah mendapatkan intervensi. Hal ini didasarkan pada nilai p value (Asymp. Sig 2 tailed) sebesar 0,005 di mana kurang dari batas kritis penelitian 0.05 maka hipotesis dalam penelitian ini diterima, bahwa bimbingan kelompok dengan teknik group exercise efektif untuk meningkatkan self-esteem remaja usia 15-17 tahun di LKSA Taman Harapan Muhammadiyah Bandung.;--- Selfesteemis a value within the individual of decencyas a human being based on self-recognition of owned the behaviors. Self esteem was formed by three aspect: 1. self of understanding, 2. feelingtoward life, 3. relationships with others. This study aimed to: 1) determine student’s self-esteem profile in LKSA Taman Harapan Muhammadiyah Bandung, 2) increasestudent’s self-esteem through group guidance exercise technique. This research used one group pretest-post test design method with one of the pre-experimental designs. Study participants were 10 adolescents aged 15-17 years in LKSA Taman Harapan Muhammadiyah Bandung who had indicated lower self esteem. Analysis data techniques used descriptive techniques percentage and Wilcoxon test. Post-test results showed that self-esteem 10 adolescents aged 15-17 years is increased significantly through group guidance program with group exercise technique.The result showed that group guidance program with group exercise technique was effective to increase student’s self-esteem, because p value 0,005< 0,05 (α).The hypothesis in this research is acceptable, that group guidance program through group exercise technique is effective to increase self-esteem in LKSA Taman Harapan Muhammadiyah Bandun

The possible focal points of small regions's: Harghita County's development in the 2014 - 2020's EU budget period

It is a known fact that EU founds absorption rate in Romania is very slow. We were curious about the situation of our region - Center Region - and it's counties, and we wanted to see what are the main differences between the region's counties. We used information from official statistical sites, websites of local authorities, press releases and we also based on own experience. Analyzing the situation, development plans and SWOT results of the counties, we realized that according to infrastructure differences our county in the near future will not be as good performer like Brasov, Sibiu and Mures, so we further focused on similarities. The most important common characteristic of all these counties is the loyalty for land, for culture, for local products. Almost every settlement has something special (pie, sausages, dairy, manufacture products), and the demand for slow- and healthy food is growing. So we have to fructify this like strength, and offer the tourists something special, a piece of our region, our culture, and our rural life. We also have to pay attention of our recognized potato plantations, and exploit the possibilities for livestock-breeding. The main sectors which still need to be developed are the infrastructure, agriculture, tourism and the competitiveness of the companies. All these with the help of educated human resources. So in the next budget period we have to focus to these sectors and pay attention for not only apply for resources just for attracting founds, but to have sustainable projects that will ensure a sustainable development both for individuals, companies and local authorities

Nilai Estetis Musik dalam Rentang Sejarah Musik Barat

The history of Western music, historically, has been changing for a long time; from one period to other period until the present day. In music, the chaging automatically changes its forms, styles, characteristics, harmony, and particularly its aesthetics values. Then, the changing triggers development. Dominantly the development is inluenced by two dominant aspects, i.e. internal aspect and external aspect. The music history said that the period of Middle Ages was influenced by political religion which was placed under Chatolic church authorization. Renaisance period was influenced by spirit of individualism and humanism, and also enthusiasm of anthropocentrism. The Barock era was shadowed by the political changing in Western Europe. The Classic dan Romantic period was shaded by the passion of territorial expansion and nationalism that was marked by Franch Revolution. After World War I and II the social changes were determined by the development of technology. It becomes significant factor. In musicology context, the development of technology has created several new music instruments. The relationship between internal and external aspect occurs correlative and the aesthetics values in music has been influenced by several aspects above. The existence of music is not caused by itself, but it influenced by another aspects

„Uparte trwanie baroku” w recepcji wierszy Stanisława Barańczaka

The article focuses on the functioning of the term ‘baroque’ in the reception of Stanisław Barańczak’s poems. The author takes into account the context of fashion for returning to the legacy of the baroque which became visible after 1956 in both poetry itself and in the discourse of both literary criticism and literary studies

Barok w mistyce – hipertrofia myśli i emocji? (1)

In mysticism, I am mostly interested in emanations of some type of intensity of existence, which abstracts from the biological one. Revoking a treaty with time results in a puzzling personal experience, the story of which can be treated as an existential lesson. In mysticism, the truth becomes known through faith. It finds its source in love, which is the soul’s response for the salutary love of God directed at it. As a refusal of the demands of human nature, mysticism offers an entrance into the realm of the spirit and transcendence. The latter is approached by man through a sacrifice of love, which cleanses him of the ontological stain and guilt. The first stage of this peregrination is purification. It is an act of conscience stimulated by the vision of Christ’s passion, foreseeing death and inevitable Judgement. Purification is an encouragement for contrition and responsibility going beyond the temporal limits. In the second stage of the journey to God (illumination), a prayer for grace of life under the aegis of the cross substitutes the lament over oneself. It will be a life of humility, contemplation and doloristic imitation, crowned with love understood as following the intention of God