37 research outputs found

    Cisplatin plus paclitaxel and bevacizumab versus carboplatin plus paclitaxel and bevacizumab for the first-line treatment of metastatic or recurrent cervical cancer

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    OBJECTIVE: Cisplatin-paclitaxel and bevacizumab is a frequently used treatment regimen for metastatic or recurrent cervical cancer, and carboplatin-paclitaxel and bevacizumab are also among the recommended regimens. In this study we aimed to evaluate the efficacy of these two regimens for the treatment of metastatic or recurrent cervical cancer. METHODS: Patients with metastatic or recurrent cervical cancer treated with cisplatin-paclitaxel and bevacizumab or carboplatin-paclitaxel and bevacizumab were retrospectively evaluated in this study. The clinical and demographic characteristics of patients in each group were evaluated. Median overall survival, progression-free survival, and response rates between the two groups were compared. RESULTS: A total of 250 patients were included. Overall, the numbers of patients with recurrent disease and metastatic disease were 159 and 91, respectively. The most common histologic subtype was squamous cell carcinoma (83.2%). The median duration of follow-up was 13.6 (range 0.5-86) months. The median progression-free survival was 10.5 (95% CI 9.0 to 11.8) months in the cisplatin-paclitaxel and bevacizumab group (group 1), and 10.8 (95%ÔÇëCI 8.6 to 13.0) months in the carboplatin-paclitaxel and bevacizumab group (group 2) (HR 1.20; 95%ÔÇëCI 0.88 to 1.63; p=0.25). The median overall survival was 19.1 (95%ÔÇëCI 13.0 to 25.1) months in group 1 and 18.3 (95%ÔÇëCI 15.3 to 21.3) months in group 2 (HR 1.28; 95%ÔÇëCI 0.91 to 1.80; p=0.15). CONCLUSIONS: There is no survival difference between cisplatin or carboplatin combined with paclitaxel and bevacizumab in metastatic or recurrent cervical cancer

    IS INGUINAL HERNIA A RISK FACTOR FOR VARICOCELE IN THE YOUNG MALE POPULATION?

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    OBJECTIVES: The aim of this study is to investigate the role of the inguinal hernia over the development of varicocele, in cases with accompanying inguinal hernia. METHODS: The continuous variables were calculated from mean and standard deviation, and intermittent variables were calculated over percentage and frequency. Normality testing was performed on continuous variables using the Kolmogorov-Smirnov test. Univariate analyses were performed using the unpaired Mann-Whitney U test and Chi-squared test was used for proportions. Kendall's tou-b correlation coefficient was used for correlition coefficient. Logistic regression modeling were used to identify the impact of inguinal hernias on selected cases. The data were analyzed with SPSS (TM) for Windows 22 (SPSS,Chicago, IL). RESULTS: Twelve cases (23.1\%) in the inguinal hernia group also had varicocele, which was relatively high, whereas 12 cases with inguinal hernia in the varicocele group corresponded to only were 4.02\% (12/52 (23.1\%) vs 12/298 (4.02\%)). On the other hand, as a result of the binary logistic regression, we found statistically significant difference in the probability of being diagnosed varicocele among the patients with inguinal hernia as 1.94 times. CONCLUSIONS: We think that in addition to the direct compression of some of the inguinal hernias on testicular veins, the potential for a combination of common enzymatic and biochemical disorders in some of the cases involving these two disorders may be play role

    Is inguinal hernia a risk factor for varicocele in the young male population?

    No full text
    Objectives: The aim of this study is to investigate the role of the inguinal hernia over the development of varicocele, in cases with accompanying inguinal hernia. Methods: The continuous variables were calculated from mean and standard deviation, and intermittent variables were calculated over percentage and frequency. Normality testing was performed on continuous variables using the Kolmogorov-Smirnov test. Univariate analyses were performed using the unpaired Mann-Whitney U test and Chi-squared test was used for proportions. Kendall's tau-b correlation coefficient was used for correlition coefficient. Logistic regression modeling were used to identify the impact of inguinal hernias on selected cases. The data were analyzed with SPSSÔäó for Windows 22 (SPSS,Chicago, IL). Results: Twelve cases (23.1%) in the inguinal hernia group also had varicocele, which was relatively high, whereas 12 cases with inguinal hernia in the varicocele group corresponded to only were 4.02% (12/52 (23.1%) vs 12/298 (4.02%) ). On the other hand, as a result of the binary logistic regression, we found statistically significant difference in the probability of being diagnosed varicocele among the patients with inguinal hernia as 1.94 times. Conclusions: We think that in addition to the direct compression of some of the inguinal hernias on testicular veins, the potential for a combination of common enzymatic and biochemical disorders in some of the cases involving these two disorders may be play role

    Is inguinal hernia a risk factor for varicocele in the young Male population?

    No full text
    OBJECTIVES: The aim of this study is to investigate the role of the inguinal hernia over the development of varicocele, in cases with accompanying inguinal hernia. METHODS: The continuous variables were calculated from mean and standard deviation, and intermittent variables were calculated over percentage and frequency. Normality testing was performed on continuous variables using the KolmogorovÔÇôSmirnov test. Univariate analyses were performed using the unpaired MannÔÇôWhitney U test and Chi-squared test was used for proportions. KendallÔÇÖs tau-b correlation coefficient was used for correlition coefficient. Logistic regression modeling were used to identify the impact of inguinal hernias on selected cases. The data were analyzed with SPSSÔäó for Windows 22 (SPSS,Chicago, IL). RESULTS: Twelve cases (23.1%) in the inguinal hernia group also had varicocele, which was relatively high, whereas 12 cases with inguinal hernia in the varicocele group corresponded to only were 4.02% (12/52 (23.1%) vs 12/298 (4.02%)). On the other hand, as a result of the binary logistic regression, we found statistically significant difference in the probability of being diagnosed varicocele among the patients with inguinal hernia as 1.94 times. CONCLUSIONS: We think that in addition to the direct compression of some of the inguinal hernias on testicular veins, the potential for a combination of common enzymatic and biochemical disorders in some of the cases involving these two disorders may be play role. ┬ę 2019 Iniestares, S.A.. All rights reserved

    The relationships between economy and military coup

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    Bu ├žal─▒┼čmada ekonomi ve askeri darbeler ili┼čkisi incelenmektedir. Ekonomik geli┼čmeler siyasi geli┼čmelerden ba─č─▒ms─▒z olarak ortaya ├ž─▒kmamaktad─▒r. Askeri darbeler ekonomik sistemi derinden etkileyen en ├Ânemli unsurlardand─▒r. Darbeler hukuk kurallar─▒n─▒ i┼člemez hale getirir. Yasalar─▒n i┼člemedi─či durumlarda toplum g├╝veni sars─▒ld─▒─č─▒ i├žin ekonomik d├╝zen ortadan kalkar. Darbe ve ter├Âr ekonomide olumsuzluklara neden olarak topl umun refah─▒n─▒ d├╝┼č├╝r├╝r. Ekonomik analizler yap─▒l─▒rken siyasi fakt├Ârler ├žo─ču zaman d─▒┼čsal bir de─či┼čken olarak de─čerlendirilir. Ekonomi ├╝zerindeki en ├Ânemli siyasi etki askeri kurumlar─▒n ├╝lkeyi y├Ânetmek i├žin yapt─▒klar─▒ darbe giri┼čimiyle ortaya ├ž─▒kar. D├╝nyadaki askeri darbeleri geli┼čimini inceleyen bu ├žal─▒┼čmada, askeri darbelerin olu┼čumu ve sonras─▒ndaki geli┼čmelerle makro ekonomik fakt├Ârlerin nas─▒l etkilendi─či ara┼čt─▒r─▒lmaktad─▒r. Bu ├žal─▒┼čmada d├╝nyada darbeler sistematik olarak incelenmi┼č ve darbelerin se├žimler kadar yayg─▒n oldu─ču g├Âzlemlenmi┼čtir. Askeri darbe yap─▒lan ├╝lkelerdeki darbe ├Âncesi ve sonras─▒ makro ekonomik g├Âstergeler incelenmi┼čtir. Darbe sonras─▒nda olu┼čan y├Ânetimlerin makro ekonomik g├Âstergelerde k─▒sa d├Ânemde olumlu etkide bulunurken uzun d├Ânemde bu etkinin olumsuz oldu─ču g├Âzlemlenmi┼čtir

    Terrorism and International Trade Relations inthe Middle East Countries

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    Bu ├žal─▒┼čmada, ter├Ârizmin uluslararas─▒ ticarete olan etkisi Ortado─ču ve Kuzey Afrika ├╝lkeleri ele al─▒narak incelenmektedir. 1980 y─▒l─▒ndan ba┼člayarak ve ├Âzellikle 1990ÔÇÖlardan itibaren d├╝nya ticareti h─▒zla geli┼čmi┼čtir. 1980-2016 y─▒llar─▒ aras─▒nda uluslararas─▒ ticaretin geli┼čmesi yolunda ├žok ├Ânemli siyasi ve bilimsel geli┼čmeler olmakla beraber ter├Âr olaylar─▒ndaki h─▒zl─▒ art─▒┼č uluslararas─▒ ticarette belirli s─▒n─▒rlamalara neden olmu┼čtur. Globalle┼čme olgusuyla birlikte uluslararas─▒ ticaret olabildi─čince geni┼člemeye ba┼člam─▒┼čt─▒r. ─░nternet ve bili┼čim teknolojilerindeki geli┼čimde ticaretin ├žok daha h─▒zl─▒ kolay yap─▒lmas─▒n─▒ sa─člam─▒┼čt─▒r. ├ľzellikle ├╝lkeleraras─▒ hizmet ticaretinde ├žok h─▒zl─▒ b├╝y├╝meler meydana gelmi┼čtir. Bu olumlu geli┼čmelerle birlikte uluslararas─▒ ter├Ârizm d├╝nya ticareti ├╝zerine olumsuz etkide bulunmaktad─▒r. 1980-2016 y─▒llar─▒ aras─▒nda ter├Âr olaylar─▒n─▒n artmas─▒ ticari faaliyetlerde azalmaya yol a├žt─▒─č─▒na dair ├Ânemli ipu├žlar─▒ vard─▒r. Bu ├žal─▒┼čma ter├Ârizmin Ortado─ču ├╝lkelerinin d─▒┼č ticaretini etkileyip etkilemedi─čini analiz etmektedir. ├çal─▒┼čmada 1980-2016 y─▒llar─▒ aras─▒nda d─▒┼č ticaretin ter├Âre kar┼č─▒ duyarl─▒l─▒─č─▒ esneklik kavram─▒ ile ├Âl├ž├╝lm├╝┼č ve ter├Ârizmin uluslararas─▒ ticaret ├╝zerindeki birtak─▒m etkilere sahip oldu─ču tespit edilmi┼čtir

    Ortado─ču ├ťlkelerinde Ticaret Hacmi ve Ter├Âr ─░li┼čkisi

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    In this study, the effect of terrorism on international trade is examined by considering the countries of the Middle East and North Africa (MENA). Beginning in 1980 and especially since the 1990s, world trade has developed rapidly. Although, along with the important political and scientific developments towards the development of international trade in 1980 - 2016, the rapid increase in terrorist incidents has caused certain limitations in international trade. In the development of Internet and information technologies, it made trading much easier and faster. Particularly in the service trade between countries, they have grown very fast. Along with these positive developments, international terrorism has a negative effect on world trade. Between 1980 and 2016, there are important clues that the increase in terrorist incidents has led to a decline in commercial activity. This study analyzes whether terrorism affects the foreign trade of the Middle East and North African countries. During the 1980-2016 period, the sensitivity of foreign trade to terrorism was measured by the notion of flexibility, and terrorism has had some impact on international trade
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