The Anglo-German Naval Agreement of 1935: A Study of the Nexus of British Naval Policy and Foreign Policy

The Anglo-German Naval Agreement of June 18, 1935, came as a complete surprise and was contrary to established British policy; what were the circumstances that influenced the decision to reach the accord with Germany? Was it appeasement? If the compact was not political, then what was its primary purpose and who was responsible for the treaty

20th Annual Elementary Choral Festivals

Program listing performers and works performe

IgM memory B cells: a mouse/human paradox

Humoral memory is maintained by two types of persistent cells, memory B cells and plasma cells, which have different phenotypes and functions. Long-lived plasma cells can survive for a lifespan within a complex niche in the bone marrow and provide continuous protective serum antibody levels. Memory B cells reside in secondary lymphoid organs, where they can be rapidly mobilized upon a new antigenic encounter. Surface IgG has long been taken as a surrogate marker for memory in the mouse. Recently, however, we have brought evidence for a long-lived IgM memory B cell population in the mouse, while we have also argued that, in humans, these same cells are not classical memory B cells but marginal zone (MZ) B cells which, as opposed to their mouse MZ counterpart, recirculate and carry a mutated B cell receptor. In this review, we will discuss these apparently paradoxical results