Newsworthiness of multiple identity organizations

Media reputation is an important asset of every organization but might even be more delicate for a multiple identity organization (MIO). MIOs usually have central, distinctive, and enduring characteristics belonging to two antithetical value systems, often the ideological and the utilitarian value system. This qualitative interview study explores journalists' understanding and coverage of MIOs and how both are impacted by journalistic role perceptions and by the nature and behavior of such organizations. The findings of this research provide insight into the journalistic production process and could be instructive for the media management of MIOs. The interviewees recognized the potentially problematic character of an MIO but were divided about the newsworthiness of organizational identity multiplicity. Besides a group of “explainer” journalists, who were neutral towards MIOs, there were “watchdog” journalists who were extra sharp-eyed when an MIO was involved. They observed a lack of transparency about the commercial goals and profits. Controversy in terms of internal and external tensions was found to be a particularly salient news value with respect to an MIO. During the COVID-19 pandemic the journalist's interest in the tension between the organization's identities seemed to disappear. The central conclusion is that organizational identity multiplicity may trigger the critical attention of journalists. MIOs should improve transparency, especially considering their commercial activities

Reporting on political acquaintances: Personal interactions between political journalists and politicians as a determinant of media coverage

To explain which politicians make it into the news, this study considers the influence of the personal interactions between political journalists and politicians. While theoretically plausible, there is little empirical evidence that the personal interactions between reporters and politicians are associated with news content. This study draws on a survey of political journalists combined with a content analysis of their newspaper articles to analyze how personal interactions with politicians and the background characteristics of journalists relate to their news-making. Overall, it is found that journalists report more often and more positively about politicians they have personal contact with and about those politicians who hold similar political views. Hence, personal interactions with journalists can be useful for politicians to attract (positive) media coverage

Subspace Chronicles: How Linguistic Information Emerges, Shifts and Interacts during Language Model Training

Representational spaces learned via language modeling are fundamental to Natural Language Processing (NLP), however there has been limited understanding regarding how and when during training various types of linguistic information emerge and interact. Leveraging a novel information theoretic probing suite, which enables direct comparisons of not just task performance, but their representational subspaces, we analyze nine tasks covering syntax, semantics and reasoning, across 2M pre-training steps and five seeds. We identify critical learning phases across tasks and time, during which subspaces emerge, share information, and later disentangle to specialize. Across these phases, syntactic knowledge is acquired rapidly after 0.5% of full training. Continued performance improvements primarily stem from the acquisition of open-domain knowledge, while semantics and reasoning tasks benefit from later boosts to long-range contextualization and higher specialization. Measuring cross-task similarity further reveals that linguistically related tasks share information throughout training, and do so more during the critical phase of learning than before or after. Our findings have implications for model interpretability, multi-task learning, and learning from limited data.</p

Blood and brain biochemistry and behaviour in NTBC and dietary treated tyrosinemia type 1 mice

Tyrosinemia type 1 (TT1) is a rare metabolic disease caused by a defect in the tyrosine degradation pathway. Neurocognitive deficiencies have been described in TT1 patients, that have, among others, been related to changes in plasma large neutral amino acids (LNAA) that could result in changes in brain LNAA and neurotransmitter concentrations. Therefore, this project aimed to investigate plasma and brain LNAA, brain neurotransmitter concentrations and behavior in C57 Bl/6 fumarylacetoacetate hydrolase deficient (FAH-/-) mice treated with 2-(2-nitro-4-trifluoromethylbenoyl)-1,3-cyclohexanedione (NTBC) and/or diet and wild-type mice. Plasma and brain tyrosine concentrations were clearly increased in all NTBC treated animals, even with diet (p <0.001). Plasma and brain phenylalanine concentrations tended to be lower in all FAH-/- mice. Other brain LNAA, were often slightly lower in NTBC treated FAH-/- mice. Brain neurotransmitter concentrations were usually within a normal range, although serotonin was negatively correlated with brain tyrosine concentrations (p <0.001). No clear behavioral differences between the different groups of mice could be found. To conclude, this is the first study measuring plasma and brain biochemistry in FAH-/- mice. Clear changes in plasma and brain LNAA have been shown. Further research should be done to relate the biochemical changes to neurocognitive impairments in TT1 patients

Bacterial pore-forming toxins: the (w)hole story?

Pore-forming toxins (PFTs) are the most common class of bacterial protein toxins and constitute important bacterial virulence factors. The mode of action of PFT is starting to be better understood. In contrast, little is known about the cellular response to this threat. Recent studies reveal that cells do not just swell and lyse, but are able to sense and react to pore formation, mount a defense, even repair the damaged membrane and thus survive. These responses involve a variety of signal-transduction pathways and sophisticated cellular mechanisms such as the pathway regulating lipid metabolism. In this review we discuss the different classes of bacterial PFTs and their modes of action, and provide examples of how the different bacteria use PFTs. Finally, we address the more recent field dealing with the eukaryotic cell response to PFT-induced damag