Mode-division-multiplexed 3x112-Gb/s DP-QPSK transmission over 80 km few-mode fiber with inline MM-EDFA and blind DSP

We show transmission of a 3x112-Gb/s DP-QPSK mode-division-multiplexed signal up to 80km, with and without multi-mode EDFA, using blind 6x6 MIMO digital signal processing. We show that the OSNR-penalty induced by mode-mixing in the multi-mode EDFA is negligible

Investigation of the added value of CT-based radiomics in predicting the development of brain metastases in patients with radically treated stage III NSCLC

Introduction: Despite radical intent therapy for patients with stage III non-small-cell lung cancer (NSCLC), cumulative incidence of brain metastases (BM) reaches 30%. Current risk stratification methods fail to accurately identify these patients. As radiomics features have been shown to have predictive value, this study aims to develop a model combining clinical risk factors with radiomics features for BM development in patients with radically treated stage III NSCLC. Methods: Retrospective analysis of two prospective multicentre studies. Inclusion criteria: adequately staged [18F-fluorodeoxyglucose positron emission tomography-computed tomography (18-FDG-PET-CT), contrast-enhanced chest CT, contrast-enhanced brain magnetic resonance imaging/CT] and radically treated stage III NSCLC, exclusion criteria: second primary within 2 years of NSCLC diagnosis and prior prophylactic cranial irradiation. Primary endpoint was BM development any time during follow-up (FU). CT-based radiomics features (N = 530) were extracted from the primary lung tumour on 18-FDG-PET-CT images, and a list of clinical features (N = 8) was collected. Univariate feature selection based on the area under the curve (AUC) of the receiver operating characteristic was performed to identify relevant features. Generalized linear models were trained using the selected features, and multivariate predictive performance was assessed through the AUC. Results: In total, 219 patients were eligible for analysis. Median FU was 59.4 months for the training cohort and 67.3 months for the validation cohort; 21 (15%) and 17 (22%) patients developed BM in the training and validation cohort, respectively. Two relevant clinical features (age and adenocarcinoma histology) and four relevant radiomics features were identified as predictive. The clinical model yielded the highest AUC value of 0.71 (95% CI: 0.58–0.84), better than radiomics or a combination of clinical parameters and radiomics (both an AUC of 0.62, 95% CIs of 0.47–076 and 0.48–0.76, respectively). Conclusion: CT-based radiomics features of primary NSCLC in the current setup could not improve on a model based on clinical predictors (age and adenocarcinoma histology) of BM development in radically treated stage III NSCLC patients

Equalisation of Fibre Bragg gratings' group delay ripple by means of maximum likelihood sequence estimation

Fibre Bragg Gratings are a promising technology for dispersion compensation in optical links, but suffer from group delay ripple (GDR) induced penalties. We identify maximum likelihood sequence estimation (MLSE) as an efficient technique for GDR equalizatio

Method and device for transmission and reception of a polarization multiplexed optical signal

A method and a device for transmission and reception of a polarization multiplexed signal in an optical network are provided, wherein a first carrier of a first polarization and a second carrier of a second polarization are provided at different frequencies. Furthermore, a communication system is suggested comprising said device

PMD induced transmission penalties in polarization multiplexed transmission

In this paper, we investigate for the first time chromatic dispersion and nonlinearity tolerances in the presence of polarization-mode dispersion (PMD) for polarization-multiplexed (POLMUX) 2 × 10-Gb/s nonreturn-to-zero (NRZ) transmission. In polarization-multiplexing, the interaction between fiber nonlinearity and PMD can lower the nonlinear tolerance beyond the tolerances evident when considering both transmission penalties separately; the combined penalties are significantly worse than in the case for non-POLMUX transmission. In this paper, we show, through simulations comparing POLMUX with non-POMUX transmission in the presence of nonlinearity, a reduction of about a factor of three in PMD tolerance. In addition, we show that the dispersion tolerance of POLMUX transmission is severely limited in the presence of PMD. For example, a 40-ps differential group delay (DGD) with worst case coupling of the polarization channels into the fiber lowers the dispersion tolerance, resulting in a 1-dB eye-opening penalty (EOP), from 1200 to 450 ps/nm. We conclude that the interaction between PMD, chromatic dispersion, and nonlinearity leads to the worst signal impairments in POLMUX transmission and increases the effort of using polarization-multiplexing as a modulation format. © 2005 IEEE

PMD and nonlinearity-induced penalties on polarization-multiplexed transmission

We investigate penalties induced by polarization-mode dispersion (PMD) and the interaction between PMD and fiber nonlinearity on polarization-multiplexed transmission through both simulations and experiment. We find that controlling the phase difference between polarization channels can enhance the PMD tolerance in polarization-multiplexed transmission

Dispersion management in long-haul 111-Gb/s POLMUX-RZ-DQPSK transmission systems

We compare the nonlinear tolerance of 111-Gb/s POLMUX-RZ-DQPSK modulation for dispersion managed and unmanaged transmission systems on SSMF. It is shown that unmanaged transmission reduces XPM penalties and therefore allows for the highest nonlinear tolerance