Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives

New series of Schiff bases 2(a-j) and corresponding beta-lactam derivatives 3(a-j) were synthesized from cefalexin (1) as starting material. The compound (1) was reacted with different aldehydes and ketones to give Schiff bases derivatives 2(a-j). The synthesized Schiff bases were cyclized by chloroacetyl chloride in the presence of triethylamine to form beta-lactam derivatives 3(a-j). The compounds were characterized by deremination melting point, FT-IR and 1H NMR. The beta-lactam derivatives were screened in vitro antibacterial against some bacterial specie

Synthesis, Characterization and Antibacterial Studies of 2-azetidinones Compounds Derived from Amoxicillin

In this study, the new azetidinones were synthesized from Schiff bases 2(a-j) that derived from amoxicillin (1) on treatment with chloroacetyl chloride in presence of triethylamine gave azetidinone 3(a-j). The structure of these compounds have been elucidated on the basis of their physical and spectral. Azetidinone  compounds were also screened for  their antibacterial activity against some bacterial species using amoxicillin as standard

Changes in serum levels of Total protein , Albumin and Globulin in patients with Behcet's Disease.

In order to have an idea about some of biochemical changes which might play a role in the pathogenesis of Behcet's disease. Estimation of serum total protein, albumin, globulin and HLA typing were carried out in 70 patients with Behcets disease using colorematric, mathematic & microlymphocytotoxicity tests respectively, compared with 35 patients with recurrent oral ulcers, and 35 healthy control group. Hyperproteinemia, hyperglobulinemia with hypoalbuminemia were observed in those patients in comparison to control group

Serum Trace Elements ( Se+2, Cu+2, Zn+2) in Patients with Behcet's Disease

Background: Extensive reports denote the biological role of trace elements (Cu Zn ", Se ') in many various physiological and pathological conditions, one of the list is shown to be Behcet's disease (BD).The aim of this study was directed towards the distribution of trace elements (Cu 2,Zn, 2,Se 2) in sera of BD patients, and control groups. Methods: Fifty Arab Iraqi patients who fulfdled the ISO criteria for diagnosis BD.compared with 21 patients control with recurrent oral ulcer (ROU), healthy control groups (2Ihealthy relative and 21healthy volunteer). Typing HLA Class I was carried out at Alkarama hospital, by using microlympho-cytotoxicity test. The concentrations of serum Cu ', Zn ", and Se" were determined by atomic absorption spectrophotometry. Result: Variation in levels of these trace elements as significant (P < 0.001) in Cu+2concentral and decreased (P<o.001) in Se+2 concentrate were clearly noticed in patients with BD in comparison to control groups. Conclusions: Very unique striking results have come out of this study, and that is the significant increase in Cur2 level, significant decrease in Se 2 level, with non significanl decrease in Zn 2 level, were clearly observed in the patients studied groups in comparison with control groups. These results is another additional explanation to increase joint involvement occurrence in those patients ( our further documented results)

HLA-DR and DQ Antigens in Iraqi Patients with Behget's Disease

Background

Histological liver changes in streptozotocin induced diabetic mice

Streptozotocin (STZ) is selectively toxic to cells in the pancreatic islets. It is well known that STZ causes specific death of B cells and induces diabetes mellitus. This study has been conducted to detect the histological changes that could be induced in liver of adult diabetic mice. The experiments were performed using a single dose of STZ (150mg/Kg. I.P.). Animals were killed two, four and six weeks after injection. The relative percentage of liver weight and liver histology were studied. The results showed several morphological and histological alterations in liver tissues, indicated by increase in the liver percentage of liver weight, glycogen reduction, associated with lipid deposition, inflammatory cells infiltration and Kupffer cells hyperplasia. Furthermore, this study illustrated the worsening of liver histology over a short time in STZ diabetic mice