New stratigraphic data on the quaternary sediments in the Peschanaya River Valley, Northwestern Altai

© 2017 Siberian Branch of the Russian Academy of Sciences. This paper presents new data on the structure and the lithological, pedological, paleontological, and paleomagnetic features of the Middle and Upper Quaternary sediments in the Peschanaya River valley, the foothills of northwestern Altai. Those horizons contain a loess-soil sequence and sediments relating to two Middle Pleistocene interglacials. On the basis of palynological characteristics of one of the Middle Pleistocene interglacials, the succession of fl oras during the respective stages is reconstructed. The Middle Pleistocene interglacial fl oras of Western Siberia are compared with that reconstructed on the basis of the Karama site, evidencing marked differences. The fl ora around Karama included broad-leaved taxa, which were absent during the Middle Pleistocene interglacials of Western Siberia, when apart from modern arboreal taxa, only cold-resistant broad-leaved ones were present (Tilia, Corylus, Ulmus, and Juglans). The Karama fl ora resembles the last Western Siberian thermophilic fl ora-Barnaul, which existed during the long climatic warming of the Early Pleistocene, corresponding to the Tiglian in northwestern Europe (2.23-1.59 Ma BP). Since the beginning of the Middle Pleistocene, interglacial fl oras of Western Siberia have resembled modern ones. In terms of phytocenotic and palaeoclimatic features, Middle Pleistocene interglacial environments of Western Siberia display a sharp contrast with those of Barnaul and Karama

Двухшаговый экстраградиентный метод для задачи управления ресурсами

In the article is proposed a doublestep extragradient method for solving nonintrinsic problems of linear programming, variational inequalities and some related problems. The convergence of this method in general case is proved. The convergence of the method at the rate of geometric progression is proved for the problems of linear programming.Приведен двухшаговый экстраградиентный метод для решения несобственных задач линейного программирования, вариационных неравенств и смежных задач. Доказана сходимость метода в общем случае. Для задач линейного программирования доказана сходимость метода со скоростью геометрической прогрессии

Joint effect of physical factors of different nature on the human

Modern working conditions of miners in the mining industry are characterized by intensive noise and vibration, high dustiness, unfavorable microclimate, the levels of which often exceed hygienic standards. Unfortunately, the current regulatory framework does not take into account the fact that in real life most of the production personnel are exposed not to one but several factors of the working environment at the same time. Thus, the sanitary standarts established for factors that act singularly and guarant the preservation of health precisely for these conditions may be untenable. Ensuring sustainable safety when working in electrical installations should be achieved by complying with electrical safety requirements. But permissible levels of contact currents and voltages currently recommended by the International Electrotechnical Commission do not take into account the joint effect of electric current and other physical factors, and noise in particular. The effect of sound pressure level and its frequency on the resistance of the human body is proved earlier in V.V. Katsay's thesis. The study of the effect of noise on magnitude of threshold perceptible current is resumed in laboratory conditions at the Department of Life Safety of the South Ural State University. To obtain reliable results a test complex was designed and built. The complex includes a muffled chamber, sources of simulated voltages and noise, a block of recording instruments. Primary electrical safety criteria are investigated for an increased frequency (5000 Hz) under the influence of noise load. Voltages and currents that cause feelings are measured before the impact of noise and under the influence of noise with a sound pressure level of 97 dB. The dependence built calls into question the result obtained from results of previous studies on the need to reduce settings at which tools of safety shutdown trigger

Шкала NEWS2 в практике работы инфекционного госпиталя для больных COVID-19. Внедрение и результаты

Amidst the new COVID-19 pandemic, there is a need for a reliable medical tool to monitor patients’ vital conditions with clinical information continuity. This tool is essential for timely detection of the risk of the patient’s clinical state deterioration throughout all the stages of medical assistance.  The objective is to assess results of the NEWS2 score implementation at the in-patient stage of medical care.Methods. 183,732 scores of the NEWS2 score in 10,290 hospitalized patients were analyzed.  All the assessed results of the NEWS2 score were retrospectively analyzed. The NEWS2 score results were added to the United Medical Information and Analytical System of Moscow (EMIAS) database through the NEWS2 mobile application. The researchers analyzed the descriptive statistics of the score; the prognostic significance of NEWS2 in the prediction of the disease outcome was assessed as well as the accuracy of the used methods. Results. As the result of the research, deviations from standard methods in the application of the NEWS2 score were outlined, which allowed the researchers to develop the corrective measures.  The received data confirmed that interval assessment by the NEWS2 score and the trend analysis were important when making clinical and organizational decisions. Specific parameters of the score use during the COVID-19 pandemic were outlined, which helped to adjust the in-hospital procedures for clinical decision-making process, routing, and the continuity of all stages of medical assistance was established. Conclusion. The use of the NEWS2 score in medical practice makes it possible to predict the risks of clinical deterioration in the patient's condition, conduct bedside monitoring of therapy effectiveness, and optimize in-hospital routing. However, to ensure the validity of the score, it is necessary to plan activities for the personnel training and motivation, as well as to monitor careful adherence to the protocol. В условиях пандемии новой коронавирусной инфекции COVID-19 для своевременного выявления риска клинического ухудшения состояния пациентов на всех этапах оказания медицинской помощи необходим надежный и обеспечивающий преемственность клинической информации инструмент мониторинга витальных параметров. Цель: оценка результатов внедрения шкалы NEWS2 на госпитальном этапе оказания медицинской помощи.Методика. В анализ включено 183 732 оценки по шкале NEWS2 у 10 290 госпитализированных больных. К оцениваемым ретроспективно данным отнесены все результаты оценки по шкале NEWS2, внесенные в базу данных в КИС ЕМИАС посредством мобильного приложения NEWS2. Проведен анализ описательных статистик шкалы, оценена прогностическая значимость оценки по шкале NEWS2 в определении исходов заболевания, а также правильность использования методики.Результаты. Выявлены методические нарушения в работе со шкалой NEWS2, что позволило разработать меры по их коррекции. Полученные данные подтвердили необходимость интегральной оценки по шкале NEWS2 с анализом трендов для принятия клинических и организационных решений. Выявленные особенности использования шкалы в условиях пандемии COVID-19 позволили скорректировать внутрибольничные алгоритмы принятия клинических решений, маршрутизации, налажена преемственность между этапами оказания помощи. Вывод. Применение в медицинской практике шкалы NEWS2 позволяет прогнозировать риски клинического ухудшения состояния пациентов, вести прикроватный мониторинг эффективности используемой терапии, оптимизировать внутрибольничную маршрутизацию. Тем не менее для обеспечения валидности шкалы необходимо планировать работу по обучению и мотивации персонала, а также вести текущий контроль за тщательным исполнением протокола.

Genotyping of Capreolus pygargus Fossil DNA from Denisova Cave Reveals Phylogenetic Relationships between Ancient and Modern Populations

BACKGROUND: The extant roe deer (Capreolus Gray, 1821) includes two species: the European roe deer (C. capreolus) and the Siberian roe deer (C. pygargus) that are distinguished by morphological and karyotypical differences. The Siberian roe deer occupies a vast area of Asia and is considerably less studied than the European roe deer. Modern systematics of the Siberian roe deer remain controversial with 4 morphological subspecies. Roe deer fossilized bones are quite abundant in Denisova cave (Altai Mountains, South Siberia), where dozens of both extant and extinct mammalian species from modern Holocene to Middle Pleistocene have been retrieved. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed a 629 bp fragment of the mitochondrial control region from ancient bones of 10 Holocene and four Pleistocene Siberian roe deer from Denisova cave as well as 37 modern specimen belonging to populations from Altai, Tian Shan (Kyrgyzstan), Yakutia, Novosibirsk region and the Russian Far East. Genealogical reconstructions indicated that most Holocene haplotypes were probably ancestral for modern roe deer populations of Western Siberia and Tian Shan. One of the Pleistocene haplotypes was possibly ancestral for modern Yakutian populations, and two extinct Pleistocene haplotypes were close to modern roe deer from Tian Shan and Yakutia. Most modern geographical populations (except for West Siberian Plains) are heterogeneous and there is some tentative evidence for structure. However, we did not find any distinct phylogenetic signal characterizing particular subspecies in either modern or ancient samples. CONCLUSION/SIGNIFICANCE: Analysis of mitochondrial DNA from both ancient and modern samples of Siberian roe deer shed new light on understanding the evolutionary history of roe deer. Our data indicate that during the last 50,000 years multiple replacements of populations of the Siberian roe deer took place in the Altai Mountains correlating with climatic changes. The Siberian roe deer represent a complex and heterogeneous species with high migration rates and without evident subspecies structure. Low genetic diversity of the West Siberian Plain population indicates a recent bottleneck or founder effect

A doublestep extragradient method for solving a resource management problem

In the article is proposed a doublestep extragradient method for solving nonintrinsic problems of linear programming, variational inequalities and some related problems. The convergence of this method in general case is proved. The convergence of the method at the rate of geometric progression is proved for the problems of linear programming

THE DEVELOPMENT OF APPROACHES FOR OBTAINING AUTOMATED SOLUTION ON THE FORMATION OF THE CURRICULUM

Modeling of training processes contributes to obtaining effective solutions of problems in the educational system. One of the most important tasks in the planning of the educational process is computer-aided curriculum design taking into account imposed limitations and the requirements set educational standards and institutions in accordance with the competence-based approach. Despite the considerable amount of the problem research, a systematic formulation of its solution does not exist. The approach is designed to obtain such a decision involving the relationship between disciplines, competencies and teachers. Features of the approach are connected with the formalization and generalization of semi-structured data. Its processing is possible by using the basis of modern decision-making methods with initial uncertainty. Approaches to solving these problems are proposed. Based on the received set of education profile field competences the formation model of the curriculum is constructed. This problem can be considered as an multi-criteria optimization problem

New stratigraphic data on the quaternary sediments in the Peschanaya River Valley, Northwestern Altai

© 2017 Siberian Branch of the Russian Academy of Sciences. This paper presents new data on the structure and the lithological, pedological, paleontological, and paleomagnetic features of the Middle and Upper Quaternary sediments in the Peschanaya River valley, the foothills of northwestern Altai. Those horizons contain a loess-soil sequence and sediments relating to two Middle Pleistocene interglacials. On the basis of palynological characteristics of one of the Middle Pleistocene interglacials, the succession of fl oras during the respective stages is reconstructed. The Middle Pleistocene interglacial fl oras of Western Siberia are compared with that reconstructed on the basis of the Karama site, evidencing marked differences. The fl ora around Karama included broad-leaved taxa, which were absent during the Middle Pleistocene interglacials of Western Siberia, when apart from modern arboreal taxa, only cold-resistant broad-leaved ones were present (Tilia, Corylus, Ulmus, and Juglans). The Karama fl ora resembles the last Western Siberian thermophilic fl ora-Barnaul, which existed during the long climatic warming of the Early Pleistocene, corresponding to the Tiglian in northwestern Europe (2.23-1.59 Ma BP). Since the beginning of the Middle Pleistocene, interglacial fl oras of Western Siberia have resembled modern ones. In terms of phytocenotic and palaeoclimatic features, Middle Pleistocene interglacial environments of Western Siberia display a sharp contrast with those of Barnaul and Karama