Buddhist monasteries facilitated landscape conservation on the Qinghai-Tibetan Plateau

Context: The Sanjiangyuan region of the Qinghai-Tibetan Plateau—also known as the “Three Rivers’ Headwaters”—is the origin of the Yellow, Yangtze, and Mekong Rivers and therefore the key water source for hundreds of millions of downstream residents. Protecting this region’s ecosystems is a key priority for sustainable development in China and Asia. An important social dimension of Sanjiangyuan is the long-established and widespread presence of Tibetan Buddhism, particularly as manifested in the large number of monasteries throughout the region. However, the influence of cultural factors on environmental change remains largely understudied here. / Objective: We focus on two types of spatial associations—point-point and point-area features—to quantitatively investigate the effects of Buddhist monasteries on land use/cover change (LUCC) in surrounding landscapes. / Methods: We conduct a spatially-explicit analysis of Sanjiangyuan for two periods, 1990–2000 and 2010–2015, to identify and quantify the influence of the presence and spatial distributions of Buddhist monasteries on LUCC compared to village communities that lack monasteries. / Results: We found that the presence of monasteries is highly correlated with the preservation of natural ecosystems, specifically of grasslands and forests. Within monastery buffer zones with radii between 1 and 10 km, 7.13–9.30% more grassland area and 7.14–7.47% more forest area remained around monasteries compared to villages. This contrast decreased with increasing distance to the monastery/village. Overall, built-up areas were also much smaller around monasteries than around villages, while unused land was more commonly transformed to forests and grasslands around monasteries. / Conclusions: These findings strongly support the idea that Buddhist culture, as manifested through its physical institutions and communities, are instrumental in achieving desired landscape conservation outcomes

Role of multiple dual-phase 18F-FDG PET/CT metabolic parameters in differentiating adenocarcinomas from squamous cell carcinomas of the lung

Purpose: To evaluate the ability of multiple dual-phase 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) metabolic parameters to distinguish the histological subtypes of non-small cell lung cancer (NSCLC). Methods: Data from 127 patients with non-small cell lung cancer who underwent preoperative dual-phase 18F-FDG PET/CT scanning at the PET-CT center of our hospital from December 2020 to October 2021 were collected, and the metabolic parameters of their primary lesions were measured and analyzed retrospectively. Intraclass correlation coefficients (ICC) were calculated for consistency between readers. Metabolic parameters in the early (SUVpeak, SUVmean, SUVmin, SUVmax, MTV, and TLG) and delayed phases (dpSUVpeak, dpSUVmean, dpSUVmin, dpSUVmax, dpMTV, and dpTLG) were calculated. We drew receiver operating characteristic (ROC) curves to compare the differences in different metabolic parameters between the adenocarcinoma (AC) and squamous cell carcinoma (SCC) groups and evaluated the ability of different metabolic parameters to distinguish AC from SCC. Results: Inter-reader agreement, as assessed by the intraclass correlation coefficient (ICC), was good (ICC = 0.71, 95% CI:0.60–0.79). The mean MTV, SUVmax, TLG, SUVpeak, SUVmean, dpSUVmax, dpTLG, dpSUVpeak, dpSUVmean, and dpSUVmin of the tumors were significantly higher in SCC lesions than in AC lesions (P = 0.049, < 0.001, 0.016, < 0.001, 0.001, < 0.001, 0.018, < 0.001, 0.001, and 0.001, respectively). The diagnostic efficacy of the metabolic parameters in 18F-FDG PET/CT for differentiating adenocarcinoma from squamous cell carcinoma ranged from high to low as follows: SUVpeak (AUC = 0.727), SUVmax (AUC = 0.708), dpSUVmax (AUC = 0.699), dpSUVpeak (AUC = 0.698), TLG (AUC = 0.695), and dpTLG (AUC = 0.692), SUVmean (AUC = 0.690), dpSUVmean (AUC = 0.687), dpSUVmin (AUC = 0.680), SUVmin (AUC = 0.676), and MTV (AUC = 0.657). Conclusions: Squamous cell carcinoma of the lung had higher mean MTV, SUVmax, TLG, SUVpeak, SUVmean, SUVmin, dpSUVpeak, dpSUVmean, dpSUVmin, dpSUVmax, and dpTLG than AC, which can be helpful tools in differentiating between the two. The metabolic parameters of the delayed phase (2 h after injection) 18F-FDG PET/CT did not improve the diagnostic efficacy in distinguishing lung AC from SCC. Conventional dual-phase 18F-FDG PET/CT is not recommended

Integrating ecosystem services supply and demand on the Qinghai-Tibetan Plateau using scarcity value assessment

As a result of the land degradation it causes, rapid urbanization can severely impact the form and function of the natural environment. Because of the limited availability of natural capital and the ecosystem services they provide in many regions, fluctuations in supply and demand should rigorously considered in decision-making. The Qinghai-Tibetan Plateau (QTP) is a globally-important ecoregion that generates significant ecosystem services value. Focusing on the QTP, we calculated the value change in the supply of ecosystem services using a coefficient table and the change in demand based on population, GDP, and income elasticity. The impact of supply and demand on the scarcity value of ecosystem services (ESSV) was then compared across four representative scenarios. The results showed that the ESSV on the QTP rose considerably between 1990 and 2020, particularly between 2000 and 2010. Between 1990 and 2020, the public-goods services grew faster than private-goods services. The most important element impacting the ESSV was demand-driven scarcity. The level of urbanization gradually increased during 1990–2020, with a consistent distribution of high ESSV and high urbanization across the region. High-High types and Low-Low types had a significant aggregation effect, located primarily in the north and west of the QTP, respectively. The Low-High type was scattered along with the Low-Low type, indicating fragile ecological conditions that merit greater protection from land degradation. The degree of coupling reveals an increasing degree of synergy between ESSV and urbanization on the QTP, indicating potential for more synergistic development

Comparative Analysis of Complete Mitochondrial Genomes of Three Gerres Fishes (Perciformes: Gerreidae) and Primary Exploration of Their Evolution History

Mitochondrial genome is a powerful molecule marker to explore phylogenetic relationships and reveal molecular evolution in ichthyological studies. Gerres species play significant roles in marine fishery, but its evolution has received little attention. To date, only two Gerres mitochondrial genomes were reported. In the present study, three mitogenomes of Gerres (Gerres filamentosus, Gerres erythrourus, and Gerres decacanthus) were systemically investigated. The lengths of the mitogenome sequences were 16,673, 16,728, and 16,871 bp for G. filamentosus, G. erythrourus, and G. decacanthus, respectively. Most protein-coding genes (PCGs) were initiated with the typical ATG codon and terminated with the TAA codon, and the incomplete termination codon T/TA could be detected in the three species. The majority of AT-skew and GC-skew values of the 13 PCGs among the three species were negative, and the amplitude of the GC-skew was larger than the AT-skew. The genetic distance and Ka/Ks ratio analyses indicated 13 PCGs were suffering purifying selection and the selection pressures were different from certain deep-sea fishes, were which most likely due to the difference in their living environment. The phylogenetic tree was constructed by molecular method (Bayesian Inference (BI) and maximum Likelihood (ML)), providing further supplement to the scientific classification of fish. Three Gerres species were differentiated in late Cretaceous and early Paleogene, and their evolution might link with the geological events that could change their survival environment

Theoretical Insight into Charge-Recombination Center in Ta₃N₅ Photocatalyst: Interstitial Hydrogen

Ideal Ta₃N₅ is a promising candidate photocatalyst for solar water splitting. In a common synthetic route, both oxygen and hydrogen impurities are inevitably formed during the nitridation of TaO_<i>x</i> precursor by ammonia. The introduced hydrogen impurities would bond with oxygen in the form of hydroxyl groups, resulting in additional bands bracketing band edges. This configuration adds Ta₃N₅ electron–hole recombination centers, leading to a high onset potential. Hydrogen impurities would also introduce hydrogen bonds which aggravate charge recombination by additional charge transport paths from anions to hydroxyl recombination centers. In addition, hydride ions of hydroxyl groups may be activated into protons at high bias and may relay hole transport in Ta₃N₅, endowing the material with high saturated photocurrent. In summary, hydrogen impurities would aggravate the onset potential of Ta₃N₅ in the way of high electron–hole recombination. More broadly, hydrogen impurities may be common in (oxy)­nitrides and other covalent materials; they may add to the photocatalysts’ high onset potential via electron localizations and might introduce high charge recombination for covalent semiconductors

Development of a liquid formulation of poorly water-soluble isosteviol sodium using the co-solvent technology

<p>An intravenously injectable liquid formulation of the poorly water-soluble isosteviol sodium (ISVNa) that has a great clinical potential for cardiovascular diseases was developed using the co-solvent technology. The pH and composition of the co-solvent were optimized to obtain a stable liquid formulation (termed as STVNa) based on saline at pH 10.0 containing 25% (v/v) of ethanol and 20% (v/v) of propylene glycol. STVNa was physicochemically stable upon storage for more than 3 months under various conditions. In vitro studies showed that STVNa did not induce hemolytic effects up to 9.1% (v/v) after 3 h of incubation and it was cytocompatible up to 50 μg/mL in H2C9 cells. Furthermore, STVNa showed acceptable safety and pharmacokinetic parameters comparable with those of ISVNa in saline (dissolved at 60 °C) upon i.v. injection in Wistar rats. Overall, the results demonstrated that STVNa is a promising formulation of ISVNa for clinical translation.</p

Reactive Inorganic Vapor Deposition of Perovskite Oxynitride Films for Solar Energy Conversion

The synthesis of perovskite oxynitrides, which are promising photoanode candidates for solar energy conversion, is normally accomplished by high-temperature ammonolysis of oxides and carbonate precursors, thus making the deposition of their planar films onto conductive substrates challenging. Here, we proposed a facile strategy to prepare a series of perovskite oxynitride films. Taking SrTaO2N as a prototype, we prepared SrTaO2N films on Ta foils under NH3 flow by utilizing the vaporized SrCl2/SrCO3 eutectic salt. The SrTaO2N films exhibit solar water-splitting photocurrents of 3.0 mA cm-2 at 1.23 V vs. RHE (reversible hydrogen electrode), which increases by 270% compared to the highest photocurrent (1.1 mA cm-2 at 1.23 V vs. RHE) of SrTaO2N reported in the literature. This strategy may also be applied to directly prepare a series of perovskite oxynitride films on conductive substrates such as ATaO2N (A=Ca,Ba) and ANbO2N (A=Sr,Ba)

Oxygen-Impurity-Induced Direct–Indirect Band Gap in Perovskite SrTaO₂N

Oxynitride semiconductors are considered to be promising candidates for solar water splitting. In this work, we show that oxygen-rich SrTaO₂N has a band gap with direct–indirect character through twin valence-band maximums (VBMs), resulting in good photoelectronic responses. Compared with the direct band gap of ideal SrTaO₂N, the additional indirect VBM of the oxygen-rich solid solution was found to be due to strontium–oxygen hybridization, using orbital projections based on hybrid/GW density functional theory (DFT). This twin-VBM character was validated by strontium K-edge absorption through extended X-ray absorption fine structure (EXAFS) analysis. The twin-VBM character of the band structure can enhance the photoelectronic response and hole transport. Our findings provide a viable strategy for enhancing the solar water splitting performance of oxynitrides

Iodine nutrition and the prevalence of thyroid disease after salt iodization: a cross-sectional survey in Shanghai, a coastal area in China.

BACKGROUND: Both insufficient and excess iodine may produce thyroid disease. After salt iodization in China, the median urine iodine concentration (UIC) of children aged 8-10 years appeared adequate. However, it is unknown whether dietary changes due to rapid economic development in Shanghai have affected whole population iodine nutrition. OBJECTIVE: To assess dietary iodine intake, UIC and the prevalence of thyroid disease in the general population of Shanghai. DESIGN: A cross-sectional survey was conducted with general participants aged 5-69 years (n = 7,904) plus pregnant and lactating women (n = 380 each) selected by stratified multistage sampling. The iodine concentrations in their salt, drinking water and urine were measured. Daily iodine intake was estimated using the total diet study approach. Serum thyroid hormone concentrations and thyroid-related antibodies were measured and thyroid ultrasonography was performed. RESULTS: The median iodine concentration in salt was 29.5 mg/kg, and 12.8 µg/L in drinking water. Iodized salt, used by 95.3% of participants, contributed 63.5% of total dietary iodine. Estimated daily iodine intake was 225.96 µg. The median UIC of general participants was 146.7 µg/L; UIC <100 µg/L (iodine insufficiency) was seen in 28.6%; UIC >300 µg/L (iodine excess) in 10.1%. Pregnant women had a median UIC of 135.9 µg/L, with UIC <150 µg/L in 55.4%. Thyroid nodules and subclinical hypothyroidism were found in 27.44% and 9.17%, respectively. CONCLUSIONS: According to published criteria, the current dietary iodine intake in Shanghai was generally sufficient and safe, but insufficient in pregnant women. Thyroid nodules and subclinical hypothyroidism were the commonest thyroid diseases identified

ncRNAs-mediated overexpression of TET3 predicts unfavorable prognosis and correlates with immunotherapy efficacy in breast cancer

Breast cancer is the most frequent form of cancer in women and the primary cause of cancer-related deaths globally. DNA methylation and demethylation are important processes in human tumorigenesis. Ten-eleven translocation 3 (TET3) is a DNA demethylase. Prior research has demonstrated that TET3 is highly expressed in various human malignant tumors. However, the exact function and mechanism of TET3 in breast cancer remain unclear. In this study, we investigated TET3 expression in breast cancer and its correlation with clinicopathological characteristics of breast cancer patients. The results presented that TET3 expression was significantly increased in breast cancer and associated with the PAM50 subtype. Subsequently, we performed receiver operating characteristic, survival, and Cox hazard regression analyses. These results suggest that TET3 expression is associated with a poor prognosis and may be an indirect independent prognostic indicator in breast cancer. We also established a protein-protein interaction (PPI) network of TET3 and executed enrichment analyses of TET3 co-expressed genes, revealing their primary association with the cell cycle. Moreover, we identified noncoding RNAs (ncRNAs) contributing to TET3 overexpression using expression, correlation, and survival analyses. We identified the LINC01521/hsa-miR-29a-3p axis as the primary TET3 upstream ncRNA-related pathway in breast cancer. Furthermore, TET3 expression was positively associated with immune cell infiltration, immune cell biomarkers, and eight immune checkpoint gene expressions in breast cancer. TET3 expression also correlated with patient responses to immunotherapy. Finally, we conducted subcellular localization and immunohistochemical staining analysis of TET3 in breast cancer. We found that TET3 localized to the nucleoplasm, vesicles, and cytosol in the MCF-7 cell line, and TET3 expression was significantly upregulated in breast cancer tissues compared to para-tumor tissues. Our findings indicate that ncRNA-mediated overexpression of TET3 predicts an unfavorable prognosis and correlates with immunotherapy efficacy in breast cancer