Nonlinear robust adaptive NN control for variable-sweep aircraft

In this paper, we address the problem of altitude and velocity controllers design for variable-sweep aircraft with model uncertainties. The object is to maintain altitude and velocity during the wing transition process where mass distribution and aerodynamic parameters change significantly. Based on the functional decomposition, the longitudinal dynamics of the aircraft can be divided into altitude subsystem in non-affine pure feedback form and velocity subsystem. And then nonlinear robust adaptive NN velocity controller and altitude controller are designed with backstepping method to relax the prior requirements of aerodynamic parameters accuracy in linear LPV controller design. The method of filtered signal is used to circumvent the algebraic loop problem caused by the dynamics of non-affine pure feedback form. Dynamic surface control (DSC) and minimal learning parameters (MLP) techniques are employed to solve the problems of ‘explosion of complexity’ in the back-stepping method and the online updated parameters being too much. The robust terms have been introduced to eliminate the influences of approximation errors. According to the Lyapunov-LaSalle invariant set theorem, the semi-global boundedness and convergence of all the signals of the closed-loop system are proved. Simulation results are presented to illustrate the control algorithm with good performance

Quantized control of non-Lipschitz nonlinear systems: a novel control framework with prescribed transient performance and lower design complexity

A novel control design framework is proposed for a class of non-Lipschitz nonlinear systems with quantized states, meanwhile prescribed transient performance and lower control design complexity could be guaranteed. Firstly, different from all existing control methods for systems with state quantization, global stability of strict-feedback nonlinear systems is achieved without requiring the condition that the nonlinearities of the system model satisfy global Lipschitz continuity. Secondly, a novel barrier function-free prescribed performance control (BFPPC) method is proposed, which can guarantee prescribed transient performance under quantized states. Thirdly, a new \textit{W}-function-based control scheme is designed such that virtual control signals are not required to be differentiated repeatedly and the controller could be designed in a simple way, which guarantees global stability and lower design complexity compared with traditional dynamic surface control (DSC). Simulation results demonstrate the effectiveness of our method

The Pyroptosis-Related Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Gastric Cancer

Gastric cancer (GC) is one of the leading causes of cancer-related deaths and shows high levels of heterogeneity. The development of a specific prognostic model is important if we are to improve treatment strategies. Pyroptosis can arise in response to H. pylori, a primary carcinogen, and also in response to chemotherapy drugs. However, the prognostic evaluation of GC to pyroptosis is insufficient. Consensus clustering by pyroptosis-related regulators was used to classify 618 patients with GC from four GEO cohorts. Following Cox regression with differentially expressed genes, our prognosis model (PS-score) was built by LASSO-Cox analysis. The TCGA-STAD cohort was used as the validation set. ESTIMATE, CIBERSORTx, and EPIC were used to investigate the tumor microenvironment (TME). Immunotherapy cohorts by blocking PD1/PD-L1 were used to investigate the treatment response. The subtyping of GC based on pyroptosis-related regulators was able to classify patients according to different clinical traits and TME. The difference between the two subtypes identified in this study was used to develop a prognosis model which we named “PS-score.” The PS-score could predict the prognosis of patients with GC and his/her overall survival time. A low PS-score implies greater inflammatory cell infiltration and better response of immunotherapy by PD1/PD-L1 blockers. Our findings provide a foundation for future research targeting pyroptosis and its immune microenvironment to improve prognosis and responses to immunotherapy

Transposable elements cause the loss of self-incompatibility in citrus

Self-incompatibility (SI) is a widespread prezygotic mechanism for flowering plants to avoid inbreeding depression and promote genetic diversity. Citrus has an S-RNase-based SI system, which was frequently lost during evolution. We previously identified a single nucleotide mutation in Sm-RNase, which is responsible for the loss of SI in mandarin and its hybrids. However, little is known about other mechanisms responsible for conversion of SI to self-compatibility (SC) and we identify a completely different mechanism widely utilized by citrus. Here, we found a 786-bp miniature inverted-repeat transposable element (MITE) insertion in the promoter region of the FhiS2-RNase in Fortunella hindsii Swingle (a model plant for citrus gene function), which does not contain the Sm-RNase allele but are still SC. We demonstrate that this MITE plays a pivotal role in the loss of SI in citrus, providing evidence that this MITE insertion prevents expression of the S-RNase; moreover, transgenic experiments show that deletion of this 786-bp MITE insertion recovers the expression of FhiS2-RNase and restores SI. This study identifies the first evidence for a role for MITEs at the S-locus affecting the SI phenotype. A family-wide survey of the S-locus revealed that MITE insertions occur frequently adjacent to S-RNase alleles in different citrus genera, but only certain MITEs appear to be responsible for the loss of SI. Our study provides evidence that insertion of MITEs into a promoter region can alter a breeding strategy and suggests that this phenomenon may be broadly responsible for SC in species with the S-RNase system

Synthesis and Fungicidal Activity of 2-Imino-3-(4-arylthiazol-2-yl)-thiazolidin-4-ones and Their 5-Arylidene Derivatives

Five derivatives of 2-imino-3-(4-arylthiazol-2-yl)-thiazolidin-4-ones and a series of their 5-arylidene derivatives have been synthesized and tested for antifungal activity against seven agricultural fungi. 2-Imino-3-(2,4-dichloro-5-fluorophenylthiazol-2-yl)-4-thiazolidi-none and 2-imino- 3-(2,4-dichlorophenylthiazol-2-yl)-4-thiazolidione, both of them new compounds, exhibited higher fungicidal effects than the other compounds prepared

Synthesis and Fungicidal Activity of 2-Imino-3-(4-arylthiazol-2-yl)-thiazolidin-4-ones and Their 5-Arylidene Derivatives

Five derivatives of 2-imino-3-(4-arylthiazol-2-yl)-thiazolidin-4-ones and a series of their 5-arylidene derivatives have been synthesized and tested for antifungal activity against seven agricultural fungi. 2-Imino-3-(2,4-dichloro-5-fluorophenylthiazol-2-yl)-4-thiazolidi-none and 2-imino-3-(2,4-dichlorophenylthiazol-2-yl)-4-thiazolidione, both of them new compounds, exhibited higher fungicidal effects than the other compounds prepared

Adaptive Neural Control of Nonaffine Nonlinear Systems without Differential Condition for Nonaffine Function

An adaptive neural control scheme is proposed for nonaffine nonlinear system without using the implicit function theorem or mean value theorem. The differential conditions on nonaffine nonlinear functions are removed. The control-gain function is modeled with the nonaffine function probably being indifferentiable. Furthermore, only a semibounded condition for nonaffine nonlinear function is required in the proposed method, and the basic idea of invariant set theory is then constructively introduced to cope with the difficulty in the control design for nonaffine nonlinear systems. It is rigorously proved that all the closed-loop signals are bounded and the tracking error converges to a small residual set asymptotically. Finally, simulation examples are provided to demonstrate the effectiveness of the designed method