19 research outputs found
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Kaposi's sarcoma: immunoperoxidase staining for cytomegalovirus
An immunoperoxidase technique was used to test for cytomegalovirus (CMV) proteins in lesions of Kaposi's sarcoma from 19 patients with acquired immune deficiency syndrome (AIDS) and 3 patients without AIDS. CMV proteins could not be detected in any of the cases of Kaposi's sarcoma. Thus, while CMV genetic material may be present in these cells, the virus is not actively directing the synthesis of proteins. This eliminates reactivation of latent CMV in tumor tissue, or late infection of Kaposi's sarcoma cells as explanations for the elevated antibody titers to CMV and other evidence of CMV infection in patients with Kaposi's sarcoma. However, the possibility remains that exposure to CMV occurs as a primary event in the development of Kaposi's sarcoma. These findings indicate that, as in Kaposi's sarcoma of the elderly, the virus is inactive in Kaposi's sarcoma cells of patients with AIDS, and there is no difference between the two lesions in immunoperoxidase staining for CMV proteins
KAPOSI'S SARCOMA: IMMUNOPEROXIDASE STAINING FOR CYTOMEGALOVIRUS
An immunoperoxidase technique was used to test for cytomegalovirus (CMV) proteins in lesions of Kaposi's sarcoma from 19 patients with acquired immune deficiency syndrome (AIDS) and 3 patients without AIDS. CMV proteins could not be detected in any of the cases of Kaposi's sarcoma. Thus, while CMV genetic material may be present in these cells, the virus is not actively directing the synthesis of proteins. This eliminates reactivation of latent CMV in tumor tissue, or late infection of Kaposi's sarcoma cells as explanations for the elevated antibody titers to CMV and other evidence of CMV infection in patients with Kaposi's sarcoma. However, the possibility remains that exposure to CMV occurs as a primary event in the development of Kaposi's sarcoma. These findings indicate that, as in Kaposi's sarcoma of the elderly, the virus is inactive in Kaposi's sarcoma cells of patients with AIDS, and there is no difference between the two lesions in immunoperoxidase staining for CMV proteins
Axolotl as a Model to Study Scarless Wound Healing in Vertebrates: Role of the Transforming Growth Factor Beta Signaling Pathway
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Granular cell tumors of the skin contain myelin basic protein
Myelin basic protein, a substance found in neural structures, has been demonstrated in cutaneous granular cell tumors using a monoclonal antibody generated against myelin basic protein and an immunoperoxidase method. The substance was not found in fibrohistiocytic skin lesions. The presence of myelin basic protein in granular cell lesions of the skin supports the concept that this lesion is related closely to nerve structures
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Prekeratin immunohistochemistry in the diagnosis of undifferentiated carcinoma of the nasopharyngeal type
We investigated the value of prekeratin immunostaining in establishing the diagnosis of undifferentiated carcinoma of the nasopharyngeal type (lymphoepithelioma). As in squamous cell carcinoma of the nasopharynx, all seven lymphoepithelial carcinomas stained for prekeratin whereas other look-alike but histogenetically different neoplasms (malignant lymphoma, esthesioneuroblastoma, and small round cell sarcomas) did not stain. In addition to confirming the squamous epithelial nature of lymphoepithelioma, our findings indicated that immunoperoxidase staining for prekeratin is a useful diagnostic tool in the differential diagnosis of nasopharyngeal carcinomas in general and lymphoepithelioma in particular
Caractères structuraux et histoenzymologiques de l'astrocyte normal, réactionnel et tumoral
info:eu-repo/semantics/publishe
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Carcinoembryonic antigen in sweat-gland carcinomas
Using standard immunoperoxidase techniques, four cases of malignant sweat-gland carcinoma were examined for the presence of carcinoembryonic antigen (CEA). This substance was universally present in these lesions in spite of their wide spectrum of histologic features. CEA was mainly localized within the cytoplasm of tumor cells and in the lumina of neoplastic glands. The findings indicate that the presence of CEA in malignant skin adnexal tumors could help to identify and categorize these lesions as derived from eccrine or apocrine adnexal epithelium
Delineation of nevus cell nests in inflammatory infiltrates by immunohistochemical staining for the presence of S100 protein
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Immunohistologic identification of fungi in systemic and cutaneous mycoses
Using specific antibodies and the peroxidase-antiperoxidase technique, we were able to demonstrate a variety of fungal organisms in smears and sections of formaldehyde-fixed, paraffin-embedded tissue. The procedure is simple, fast, and accurate and may be used as an alternative to, or in conjunction with, cultural methods to identify fungi specifically