A spectral line survey of IRC +10216 between 13.3 and 18.5 GHz

A spectral line survey of IRC +10216 between 13.3 and 18.5 GHz is carried out using the Shanghai Tian Ma 65 m Radio Telescope (TMRT-65m) with a sensitivity of < 7 mK. Thirty-five spectral lines of 12 different molecules and radicals are detected in total. Except for SiS, the detected molecules are all carbon-chain molecules, including HC3N, HC5N, HC7N, HC9N, C6H, C6H-, C8H, SiC2, SiC4, c-C3H2 and l-C5H. The presence of rich carbon-bearing molecules is consistent with the identity of IRC +10216 as a carbon-rich AGB star. The excitation temperatures and column densities of the observed species are derived by assuming a local thermodynamic equilibrium and homogeneous conditions.Comment: This is the authors' version of the manuscript; 16 pages, 5 figures, 6 tables; Accepted for publication in A&A 8/17/201

The properties of the SS-wave DsDˉsD_s\bar{D}_s bound state

In this work, we investigate possible bound states of the $D_s\bar{D}_s$ system in the Bethe-Salpeter formalism in the ladder and instantaneous approximations. By numerically solving the Bethe-Salpeter equation with a kernel that includes the contributions from $\phi$ and $J/\psi$ exchanges, we confirm the existence of a bound state in the $D_s\bar{D}_s$ system. We further investigate the partial decay widths of the $D_s\bar{D}_s$ bound state into $D\bar{D}$, $\eta_c\eta$, and $J/\psi\omega$, finding that these partial widths are sensitive to the parameter $\alpha$ in our model. Notably, we observe that the dominant decay channel for the $D_s\bar{D}_s$ bound state is that into $D\bar{D}$

Studying the Dˉ1K\bar{D}_1K molecule in the Bethe-Salpeter equation approach

We interpret the $X_1(2900)$ as an $S$-wave $\bar{D}_1K$ molecular state in the Bethe-Salpeter equation approach with the ladder and instantaneous approximations for the kernel. By solving the Bethe-Salpeter equation numerically with the kernel containing one-particle-exchange diagrams and introducing three different form factors (monopole, dipole, and exponential form factors) in the verties, we find the bound state exists. We also study the decay width of the decay $X_1(2900)$ to $D^-K^+$.Comment: 13 pages, 6 figures. arXiv admin note: text overlap with arXiv:2004.14085, arXiv:1906.0900

Study on Effects of Chinese Thought and Culture on Japanese Writing:Research on the Second Language Writing by Think Aloud

Think Aloud is one of the main research methods in psychological linguistic study. It plays an important role in foreign language teaching study. This thesis researches into the second language writing process of Japanese learners whose native language are Chinese and draws the conclusion that their writing process include the characteristics of two languages. It is the characteristics that cause Japanese learners are influenced by Chinese and culture, especially in sentence structure and vocabulary. Key Words: Chinese thought; culture; Think Aloud; the second language writin

Recombinant immunotoxin anti-c-Met/PE38KDEL inhibits proliferation and promotes apoptosis of gastric cancer cells

<p>Abstract</p> <p>Background</p> <p>Our study aims to evaluate the anti-growth effects of recombinant immunotoxin (IT) anti-c-Met/PE38KDEL on gastric cancer cells, and its mechnisms.</p> <p>Methods</p> <p>Gastric cancer cells were treated with increasing doses of IT and c-Met protein was quantified by Western blotting. Cell proliferation was determined by Cell Counting Kit-8 assay (CCK). [³H]-leucine incorporation assay was used to evaluate IT inhibition of protein synthesis. Cell apoptosis was quantified by flow cytometry. Caspase activities were measured using colorimetric protease assays.</p> <p>Results</p> <p>Cell growth and protein synthesis of the gastric cancer cell lines were suppressed by IT in a dose- and time-dependent manner. IT also induced apoptosis in a dose-dependent manner. The apoptosis rates of gastric cancer cell lines MKN-45 and SGC7901 were 19.19% and 27.37%, respectively when treated with 50 ng/ml of IT. There were significant increase ofcaspase-3 activity at 24 hr of IT treatment (100 ng/ml) (P < 0.01) in these gastric cancer cell lines.</p> <p>Conclusions</p> <p>IT anti-c-Met/PE38KDEL has anti-growth effects on the gastric cancer cell lines <it>in vitro</it>, and it provides an experimental basis for c-Met-targeted therapy towards <it>in vivo </it>testing.</p

Protein Phosphatase 2C of Toxoplasma Gondii Interacts with Human SSRP1 and Negatively Regulates Cell Apoptosis

International audienceBiographical notes of the first authors: GAO Xue Juan, female, born in 1980, PhD, assistant researcher, majoring in protein-protein interaction and signaling pathways; FENG Jun Xia, female, born in 1989, majoring in pathogenic molecular mechanism of pathogenic microorganisms. Abstract Objective The protozoan Toxoplasma gondii expresses large amounts of a 37 kDa Type 2C serine-threonine phosphatase, the so-called TgPP2C which has been suggested to contribute to parasite growth regulation. Ectopic expression in mammalian cells also indicated that the enzyme could regulate growth and survival. In this study, we aimed to investigate the interaction of TgPP2C with human SSRP1 (structure-specific recognition protein 1) and the effects of TgPP2C on cell viability. Methods The yeast two hybrid system, His-tag pull-down and co-immunoprecipitation assays were used to confirm the interaction of TgPP2C with SSRP1 and determine the binding domain on SSRP1. The evaluation of cell apoptosis was performed using cleaved caspase-3 antibody and Annexin-V/PI kit combined with flow cytometry. Results We identified human SSRP1 as an interacting partner of TgPP2C. The C-terminal region of SSRP1 including the amino acids 471 to 538 was specifically mapped as the region responsible for interaction with TgPP2C. The overexpression of TgPP2C down-regulated cell apoptosis and negatively regulated apoptosis induced by DRB, casein kinase II (CKII) inhibitor, through enhanced interaction with SSRP1. Conclusion TgPP2C may be a parasitic factor capable of promoting cell survival through interaction with the host protein SSRP1, thereby creating a favorable environment for parasite growth

Impaired lipid metabolism in idiopathic pulmonary alveolar proteinosis

<p>Abstract</p> <p>Background</p> <p>It is well known that lipids abnormally accumulate in the alveoli during idiopathic pulmonary alveolar proteinosis (PAP). It is unclear, however, whether lipids also abnormally accumulate in serum. This study investigated the serum lipid panels in idiopathic PAP patients and explored the relationships between serum levels and the severity of idiopathic PAP.</p> <p>Methods and Results</p> <p>Clinical data including the level of serum lipids were evaluated in 33 non-diabetic idiopathic PAP patients and 157 healthy volunteers. Serum levels of triglyceride were higher in PAP patients than in healthy subjects (median: 192.00 mg/dl (<it>P</it>₂₅: 104.36, <it>P</it>₇₅: 219.00) <it>vs </it>119.56 mg/dl (<it>P</it>₂₅: 78.81, <it>P</it>₇₅: 193.03), <it>P </it>< 0.05), while high-density lipoprotein cholesterol (HDL-C) levels were lower in patients than in the control group (42.50 ± 10.30 <it>vs </it>51.34 ± 12.06 mg/dl, <it>P </it>< 0.01). Forced expiratory volume in one second and forced vital capacity in hypertriglyceridemia patients were lower than those in patients with normal triglyceride. Serum LDL-C and HDL-C ratio correlated negatively with PaO₂(r = -0.403, <it>P </it>< 0.05) and positively with lactate dehydrogenase (r = 0.381, <it>P </it>< 0.05).</p> <p>Conclusions</p> <p>PAP associates with high triglyceride and low HDL levels in the serum, and these lipids provide potential intervention strategy for treatment.</p