12,967 research outputs found
Hybrid modelling methodology applied to microstructural evolution during hot deformation of aluminium alloys
This is the post print version of this article. The official published version can be accessed from the link below.This paper considers how data based neurofuzzy modelling techniques for the poorly understood relationships between changing process histories and the evolution of the internal state variables of dislocation density, subgrain size and subgrain boundary misorientation can be combined with physically-based models to investigate the effects of the internal state variables on the flow stress and recrystallisation behaviour. The model uses genetic algorithms to optimise the constants and is validated for data on a range of aluminium-magnesium alloys of both high and commercial purity. It is shown that this hybrid modelling methodology supported by a knowledge base offers a flexible way
to develop the microstructrural modelling as more data and better understanding of the evolution of the internal state variables become available.Financial support from the UK Engineering and Physical Sciences Research Council was used in this study
Reimagining career guidance: towards a pluralistic perspective
Difficulties concerning the identified mis-match between supply and demand sides of the labour market are discussed. The variability of career guidance services for young people across Europe is illustrated together with policy initiatives in some cases leading to problems of professional identity and limited support to clients of the service. The risks associated with a monoculture of ‘one size fits all’ approach to guidance practice are discussed. The principles of pluralistic approaches to counselling are discussed with the suggestion that this might prove to be a fertile way forward for career guidance practice
Scanner Invariant Representations for Diffusion MRI Harmonization
Purpose: In the present work we describe the correction of diffusion-weighted
MRI for site and scanner biases using a novel method based on invariant
representation.
Theory and Methods: Pooled imaging data from multiple sources are subject to
variation between the sources. Correcting for these biases has become very
important as imaging studies increase in size and multi-site cases become more
common. We propose learning an intermediate representation invariant to
site/protocol variables, a technique adapted from information theory-based
algorithmic fairness; by leveraging the data processing inequality, such a
representation can then be used to create an image reconstruction that is
uninformative of its original source, yet still faithful to underlying
structures. To implement this, we use a deep learning method based on
variational auto-encoders (VAE) to construct scanner invariant encodings of the
imaging data.
Results: To evaluate our method, we use training data from the 2018 MICCAI
Computational Diffusion MRI (CDMRI) Challenge Harmonization dataset. Our
proposed method shows improvements on independent test data relative to a
recently published baseline method on each subtask, mapping data from three
different scanning contexts to and from one separate target scanning context.
Conclusion: As imaging studies continue to grow, the use of pooled multi-site
imaging will similarly increase. Invariant representation presents a strong
candidate for the harmonization of these data
HTS high Q resonant controller
High Tc superconductor (HTS) technology has been used to develop an advanced high Q resonant circuit and its devices. With a HTS, a very high Q circuit can be achieved; consequently special aspects such as high voltage generation and high current control can be theoretically and practically realized. Theoretical study has been carried out, as well as a practical approach has been made for the concept verification. This paper describes the theory of this high Q resonant circuit and the operational principle of its high voltage generation and current control
Power electronic-controlled high Q resonator theory with HTS technology
Power electronic-controlled switch has been used with a high-temperature superconductor (HTS) to develop an advanced high Q resonant circuit. With a HTS, a very high Q circuit can be achieved; consequently special aspects such as high voltage generation can be theoretically and practically realized. Theoretical study has been carried out for this concept and method, and this paper describes the theory of this high Q resonant circuit and the operational principle. © 2006 IEEE
Metalloporphyrin-incorporated diphosphine ligands for metal ion-binding
Poster: no. P48Diphosphine ligands have been widely used in organometallic chemistry and catalysis.1 By incorporation of functional units such as metallomacrocycles, the resulting functionalized diphosphines could exhibit unusual properties or binding behavior. In this study, we prepared several examples of ruthenium porphyrin phosphine complexes [RuII(Por)(dppm)2] (1; Por = TTP, 4-MeO-TPP, F20-TPP; dppm = bis(diphenylphosphino)methane) by a similar method to that previously reported for their congeners.2 Reaction of complexes 1 with a number of metal …published_or_final_versio
Structural effects on SAPO-34 and ZIF-8 materials exposed to seawater solutions, and their potential as desalination membranes
Monitoring Partially Synchronous Distributed Systems using SMT Solvers
In this paper, we discuss the feasibility of monitoring partially synchronous
distributed systems to detect latent bugs, i.e., errors caused by concurrency
and race conditions among concurrent processes. We present a monitoring
framework where we model both system constraints and latent bugs as
Satisfiability Modulo Theories (SMT) formulas, and we detect the presence of
latent bugs using an SMT solver. We demonstrate the feasibility of our
framework using both synthetic applications where latent bugs occur at any time
with random probability and an application involving exclusive access to a
shared resource with a subtle timing bug. We illustrate how the time required
for verification is affected by parameters such as communication frequency,
latency, and clock skew. Our results show that our framework can be used for
real-life applications, and because our framework uses SMT solvers, the range
of appropriate applications will increase as these solvers become more
efficient over time.Comment: Technical Report corresponding to the paper accepted at Runtime
Verification (RV) 201
Core excitations across the neutron shell gap in ²⁰⁷Tl
The single closed-neutron-shell, one proton-hole nucleus 207Tl was populated in deep-inelastic collisions of a 208Pb beam with a 208Pb target. The yrast and near-yrast level scheme has been established up to high excitation energy, comprising an octupol
Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: The cellular mechanism
Extensive studies have revealed that berberine, a small molecule derived from Coptidis rhizoma (Huanglian in Chinese) and many other plants, has strong anti-tumor properties. To better understand berberine-induced cell death and its underlying mechanisms in cancer, we examined autophagy and apoptosis in the human hepatic carcinoma cell lines HepG2 and MHCC97-L. The results of this study indicate that berberine can induce both autophagy and apoptosis in hepatocellular carcinoma cells. Berberine-induced cell death in human hepatic carcinoma cells was diminished in the presence of the cell death inhibitor 3-methyladenine, or following interference with the essential autophagy gene Atg5. Mechanistic studies showed that berberine may activate mitochondrial apoptosis in HepG2 and MHCC97-L cells by increasing Bax expression, the formation of permeable transition pores, cytochrome C release to cytosol, and subsequent activation of the caspases 3 and 9 execution pathway. Berberine may also induce autophagic cell death in HepG2 and MHCC97-L cells through activation of Beclin-1 and inhibition of the mTOR-signaling pathway by suppressing the activity of Akt and up-regulating P38 MAPK signaling. This is the first study to describe the role of Beclin-1 activation and mTOR inhibition in berberine-induced autophagic cell death. These results further demonstrate the potential of berberine as a therapeutic agent in the emerging list of cancer therapies with novel mechanisms. © 2010 Wiley-Liss, Inc.postprin
- …