29 research outputs found
Shape Discrimination Using the Tongue: Implications for a Visual-to-Tactile Sensory Substitution Device
Sensory substitution devices have the potential
to provide individuals with visual impairments with more information about
their environments, which may help them recognize objects and achieve more
independence in their daily lives. However, many of these devices may require
extensive training and might be limited in the amount of information that they
can convey. We tested the effectiveness and assessed some of the limitations of
the BrainPort device, which provides stimulation through a 20 × 20 electrode grid array on
the tongue. Across five experiments, including one with blind individuals, we
found that subjects were unable to accurately discriminate between simple
shapes as well as different line orientations that were briefly presented on
the tongue, even after 300 trials of practice with the device. These experiments
indicate that such a minimal training regimen with the BrainPort is not
sufficient for object recognition, raising serious concerns about the usability
of this device without extensive training
Data_Sheet_1_Diazotrophic community in the sediments of Poyang Lake in response to water level fluctuations.docx
Water level fluctuations (WLFs) are typical characteristic of floodplain lakes and dominant forces regulating the structure and function of lacustrine ecosystems. The sediment diazotrophs play important roles in contributing bioavailable nitrogen to the aquatic environment. However, the relationship between the diazotrophic community and WLFs in floodplain lakes is unknown. In this paper, we carried out a comprehensive investigation on the alpha diversity, abundance, composition and co-occurrence network of the sediment diazotrophs during different water level phases in Poyang Lake. There were no regular variation patterns in the alpha diversity and abundance of the sediment diazotrophs with the water level phase transitions. The relative abundance of some diazotrophic phyla (including Alphaproteobacteria, Deltaproteobacteri, Euryarchaeota, and Firmicutes) and genera (including Geobacter, Deferrisoma, Desulfuromonas, Rivicola, Paraburkholderia, Methylophilus, Methanothrix, Methanobacterium, and Clostridium) was found to change with the water level phase transitions. The results of ANOSIM, PerMANOVA, and DCA at the OTU level showed that the diazotrophic community structure in the low water level phase was significantly different from that in the two high water level phases, while there was no significant difference between the two high water level phases. These results indicated that the diazotrophic community was affected by the declining water level in terms of the composition, while the rising water level contributed to the recoveries of the diazotrophic community. The diazotrophs co-occurrence network was disrupted by the declining water level, but it was strengthened by the rising water level. Moreover, redundancy analysis showed that the variation of the diazotrophic community composition was mostly related to sediment total nitrogen (TN) and total phosphorous (TP). Interestingly, the levels of sediment TN and TP were also found to vary with the water level phase transitions. Therefore, it might be speculated that the WLFs may influence the sediment TN and TP, and in turn influence the diazotrophic community composition. These data can contribute to broadening our understanding of the ecological impacts of WLFs and the nitrogen fixation process in floodplain lakes.</p
Fully Transient 3D Origami Paper-Based Ammonia Gas Sensor Obtained by Facile MXene Spray Coating
Developing high-performance chemiresistive
gas sensors with mechanical
compliance for environmental or health-related biomarker monitoring
has recently drawn increasing research attention. Among them, two-dimensional
MXene materials hold great potential for room-temperature hazardous
gas (e.g., NH3) monitoring regardless of the complicated
fabrication process, insufficient 2D/3D flexibilities, and poor environmental
sustainability. Herein, a Ti3C2Tx MXene/gelatin ink was developed for patterning electrodes
through a facile spray coating. Particularly, the patterned Ti3C2Tx-based coating
exhibited good adhesion on the paper substrate against repeated peeling-off
and excellent mechanical flexibility against 1000 cyclic stretching.
The porous morphology of the coating facilitated the NH3 sensing ability. As a result, the 2D kirigami-shaped NH3 sensor exhibited a good response of 7% to 50 ppm of NH3 with detectable concentrations ranging from 5–500 ppm, decent
selectivity over interferences, etc., which could be well-maintained
even at 50% stretched state. In addition, with the help of mechanically
guided compressive buckling, 3D mesostructured MXene origamis could
be obtained, holding promise for detecting the coming direction and
height distribution of hazardous gas, e.g., the NH3. More
importantly, the as-fabricated MXene/gelatin origami paper could be
fully degraded in PBS/H2O2/cellulase solution
within 19 days, demonstrating its potential as a high-performance,
shape morphable, and environmentally friendly wearable gas sensor
Fully Transient 3D Origami Paper-Based Ammonia Gas Sensor Obtained by Facile MXene Spray Coating
Developing high-performance chemiresistive
gas sensors with mechanical
compliance for environmental or health-related biomarker monitoring
has recently drawn increasing research attention. Among them, two-dimensional
MXene materials hold great potential for room-temperature hazardous
gas (e.g., NH3) monitoring regardless of the complicated
fabrication process, insufficient 2D/3D flexibilities, and poor environmental
sustainability. Herein, a Ti3C2Tx MXene/gelatin ink was developed for patterning electrodes
through a facile spray coating. Particularly, the patterned Ti3C2Tx-based coating
exhibited good adhesion on the paper substrate against repeated peeling-off
and excellent mechanical flexibility against 1000 cyclic stretching.
The porous morphology of the coating facilitated the NH3 sensing ability. As a result, the 2D kirigami-shaped NH3 sensor exhibited a good response of 7% to 50 ppm of NH3 with detectable concentrations ranging from 5–500 ppm, decent
selectivity over interferences, etc., which could be well-maintained
even at 50% stretched state. In addition, with the help of mechanically
guided compressive buckling, 3D mesostructured MXene origamis could
be obtained, holding promise for detecting the coming direction and
height distribution of hazardous gas, e.g., the NH3. More
importantly, the as-fabricated MXene/gelatin origami paper could be
fully degraded in PBS/H2O2/cellulase solution
within 19 days, demonstrating its potential as a high-performance,
shape morphable, and environmentally friendly wearable gas sensor
Mortality, SAH grading, body weight, and neurological score.
<p>A and B: Mortality and SAH grading, no significant difference between the SAH+vehicle group and the SAH+BBG group. C: SAH induced body weight loss, BBG administration increased body weight without a significant difference. D: BBG administration improved neurological deficits at 24 hours after SAH. B and C, Error bars represent mean ± standard error of the mean. D, Error bars represent median ±25th–75th interquartile percentiles. * <i>p</i><0.05 vs. Sham; ** <i>p</i><0.01 vs. Sham; # <i>p</i><0.05 vs. SAH+vehicle group.</p
Fully Transient 3D Origami Paper-Based Ammonia Gas Sensor Obtained by Facile MXene Spray Coating
Developing high-performance chemiresistive
gas sensors with mechanical
compliance for environmental or health-related biomarker monitoring
has recently drawn increasing research attention. Among them, two-dimensional
MXene materials hold great potential for room-temperature hazardous
gas (e.g., NH3) monitoring regardless of the complicated
fabrication process, insufficient 2D/3D flexibilities, and poor environmental
sustainability. Herein, a Ti3C2Tx MXene/gelatin ink was developed for patterning electrodes
through a facile spray coating. Particularly, the patterned Ti3C2Tx-based coating
exhibited good adhesion on the paper substrate against repeated peeling-off
and excellent mechanical flexibility against 1000 cyclic stretching.
The porous morphology of the coating facilitated the NH3 sensing ability. As a result, the 2D kirigami-shaped NH3 sensor exhibited a good response of 7% to 50 ppm of NH3 with detectable concentrations ranging from 5–500 ppm, decent
selectivity over interferences, etc., which could be well-maintained
even at 50% stretched state. In addition, with the help of mechanically
guided compressive buckling, 3D mesostructured MXene origamis could
be obtained, holding promise for detecting the coming direction and
height distribution of hazardous gas, e.g., the NH3. More
importantly, the as-fabricated MXene/gelatin origami paper could be
fully degraded in PBS/H2O2/cellulase solution
within 19 days, demonstrating its potential as a high-performance,
shape morphable, and environmentally friendly wearable gas sensor
Fully Transient 3D Origami Paper-Based Ammonia Gas Sensor Obtained by Facile MXene Spray Coating
Developing high-performance chemiresistive
gas sensors with mechanical
compliance for environmental or health-related biomarker monitoring
has recently drawn increasing research attention. Among them, two-dimensional
MXene materials hold great potential for room-temperature hazardous
gas (e.g., NH3) monitoring regardless of the complicated
fabrication process, insufficient 2D/3D flexibilities, and poor environmental
sustainability. Herein, a Ti3C2Tx MXene/gelatin ink was developed for patterning electrodes
through a facile spray coating. Particularly, the patterned Ti3C2Tx-based coating
exhibited good adhesion on the paper substrate against repeated peeling-off
and excellent mechanical flexibility against 1000 cyclic stretching.
The porous morphology of the coating facilitated the NH3 sensing ability. As a result, the 2D kirigami-shaped NH3 sensor exhibited a good response of 7% to 50 ppm of NH3 with detectable concentrations ranging from 5–500 ppm, decent
selectivity over interferences, etc., which could be well-maintained
even at 50% stretched state. In addition, with the help of mechanically
guided compressive buckling, 3D mesostructured MXene origamis could
be obtained, holding promise for detecting the coming direction and
height distribution of hazardous gas, e.g., the NH3. More
importantly, the as-fabricated MXene/gelatin origami paper could be
fully degraded in PBS/H2O2/cellulase solution
within 19 days, demonstrating its potential as a high-performance,
shape morphable, and environmentally friendly wearable gas sensor
Fully Transient 3D Origami Paper-Based Ammonia Gas Sensor Obtained by Facile MXene Spray Coating
Developing high-performance chemiresistive
gas sensors with mechanical
compliance for environmental or health-related biomarker monitoring
has recently drawn increasing research attention. Among them, two-dimensional
MXene materials hold great potential for room-temperature hazardous
gas (e.g., NH3) monitoring regardless of the complicated
fabrication process, insufficient 2D/3D flexibilities, and poor environmental
sustainability. Herein, a Ti3C2Tx MXene/gelatin ink was developed for patterning electrodes
through a facile spray coating. Particularly, the patterned Ti3C2Tx-based coating
exhibited good adhesion on the paper substrate against repeated peeling-off
and excellent mechanical flexibility against 1000 cyclic stretching.
The porous morphology of the coating facilitated the NH3 sensing ability. As a result, the 2D kirigami-shaped NH3 sensor exhibited a good response of 7% to 50 ppm of NH3 with detectable concentrations ranging from 5–500 ppm, decent
selectivity over interferences, etc., which could be well-maintained
even at 50% stretched state. In addition, with the help of mechanically
guided compressive buckling, 3D mesostructured MXene origamis could
be obtained, holding promise for detecting the coming direction and
height distribution of hazardous gas, e.g., the NH3. More
importantly, the as-fabricated MXene/gelatin origami paper could be
fully degraded in PBS/H2O2/cellulase solution
within 19 days, demonstrating its potential as a high-performance,
shape morphable, and environmentally friendly wearable gas sensor
Fully Transient 3D Origami Paper-Based Ammonia Gas Sensor Obtained by Facile MXene Spray Coating
Developing high-performance chemiresistive
gas sensors with mechanical
compliance for environmental or health-related biomarker monitoring
has recently drawn increasing research attention. Among them, two-dimensional
MXene materials hold great potential for room-temperature hazardous
gas (e.g., NH3) monitoring regardless of the complicated
fabrication process, insufficient 2D/3D flexibilities, and poor environmental
sustainability. Herein, a Ti3C2Tx MXene/gelatin ink was developed for patterning electrodes
through a facile spray coating. Particularly, the patterned Ti3C2Tx-based coating
exhibited good adhesion on the paper substrate against repeated peeling-off
and excellent mechanical flexibility against 1000 cyclic stretching.
The porous morphology of the coating facilitated the NH3 sensing ability. As a result, the 2D kirigami-shaped NH3 sensor exhibited a good response of 7% to 50 ppm of NH3 with detectable concentrations ranging from 5–500 ppm, decent
selectivity over interferences, etc., which could be well-maintained
even at 50% stretched state. In addition, with the help of mechanically
guided compressive buckling, 3D mesostructured MXene origamis could
be obtained, holding promise for detecting the coming direction and
height distribution of hazardous gas, e.g., the NH3. More
importantly, the as-fabricated MXene/gelatin origami paper could be
fully degraded in PBS/H2O2/cellulase solution
within 19 days, demonstrating its potential as a high-performance,
shape morphable, and environmentally friendly wearable gas sensor
Perinatal testosterone exposure potentiates vascular dysfunction by ERβ suppression in endothelial progenitor cells
<div><p>Recent clinical cohort study shows that testosterone therapy increases cardiovascular diseases in men with low testosterone levels, excessive circulating androgen levels may play a detrimental role in the vascular system, while the potential mechanism and effect of testosterone exposure on the vascular function in offspring is still unknown. Our preliminary results showed that perinatal testosterone exposure in mice induces estrogen receptor β (ERβ) suppression in endothelial progenitor cells (EPCs) in offspring but not mothers, while estradiol (E2) had no effect. Further investigation showed that ERβ suppression is due to perinatal testosterone exposure-induced epigenetic changes with altered DNA methylation on the ERβ promoter. During aging, EPCs with ERβ suppression mobilize to the vascular wall, differentiate into ERβ-suppressed mouse endothelial cells (MECs) with downregulated expression of SOD2 (mitochondrial superoxide dismutase) and ERRα (estrogen-related receptor α). This results in reactive oxygen species (ROS) generation and DNA damage, and the dysfunction of mitochondria and fatty acid metabolism, subsequently potentiating vascular dysfunction. Bone marrow transplantation of EPCs that overexpressed with either ERβ or a SIRT1 single mutant SIRT1-C152(D) that could modulate SIRT1 phosphorylation significantly ameliorated vascular dysfunction, while ERβ knockdown worsened the problem. We conclude that perinatal testosterone exposure potentiates vascular dysfunction through ERβ suppression in EPCs.</p></div