3 research outputs found

    Lewis Acid-Catalyzed Cyclization of Enaminones with Propargylic Alcohols: Regioselective Synthesis of Multisubstituted 1,2-Dihydropyridines

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    A highly efficient BF<sub>3</sub>·Et<sub>2</sub>O-catalyzed cascade reaction of enaminones with propargylic alcohols under mild reaction conditions has been developed. This methodology offers regioselective access to multisubstituted 1,2-dihydropyridines in good to excellent yields

    Lewis Acid-Catalyzed Cyclization of Enaminones with Propargylic Alcohols: Regioselective Synthesis of Multisubstituted 1,2-Dihydropyridines

    No full text
    A highly efficient BF<sub>3</sub>·Et<sub>2</sub>O-catalyzed cascade reaction of enaminones with propargylic alcohols under mild reaction conditions has been developed. This methodology offers regioselective access to multisubstituted 1,2-dihydropyridines in good to excellent yields

    Metal/Benzoyl Peroxide (BPO)-Controlled Chemoselective Cycloisomerization of (<i>o</i>‑Alkynyl)phenyl Enaminones: Synthesis of α‑Naphthylamines and Indeno[1,2‑<i>c</i>]pyrrolones

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    Synthetic methods involving chemoselective tandem reactions for the synthesis of α-naphthylamines and indeno­[1,2-<i>c</i>]­pyrrolones starting from (<i>o</i>-aklynyl)­phenyl enaminones are described. When reactions were carried out in <i>N,N</i>-dimethyl­formamide (DMF) using a AgNO<sub>3</sub> catalyst, α-naphthylamines were obtained in up to 89% isolated yields within 2 h. Whereas indeno­[1,2-<i>c</i>]­pyrrolones were produced in high isolated yields in the presence of benzoyl peroxide (BPO) and CuCl catalysis
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