A new α-pyrone from the deep-sea actinomycete <i>Nocardiopsis dassonvillei</i> subsp. <i>dassonvillei</i> DSM 43111(T)

<p>A new α-pyrone, nocapyrone S (<b>1</b>), together with five known compounds (<b>2-6</b>), were isolated from the deep-sea actinomycete <i>Nocardiopsis dassonvillei</i> subsp. <i>dassonvillei</i> DSM 43111(T). Their structures were determined by spectroscopic analyses. The absolute configuration of <b>1</b> was established by quantum approaches. Cytotoxic activity of <b>1</b> was evaluated against K562, MCF-7, SGC7901, A375, Hela, and HepG2 cell lines.</p

A new sesquiterpene from the gorgonian coral <i>Menella</i> sp.

<p>A new sesquiterpene named menecubebane B (1) and a known analogue (2) were isolated from the gorgonian coral <i>Menella</i> sp. Their structures were elucidated by the extensive analyses of spectroscopic data and by the comparison with related literature. Cytotoxic effect against both Eca9706 and HeLa cell lines was evaluated, revealing 1 exhibited moderate cytotoxicity against the two cell lines involved with IC₅₀ values being 20.8 and 30.6 μM, respectively.</p