Supplementary document for Mid-infrared large-aperture metalens design verification and double-layer micro-optical system optimization - 6865680.pdf

Revised supplementary materia

Supplementary document for Mid-infrared large-aperture metalens design verification and double-layer micro-optical system optimization - 6833107.pdf

Supplemental materia

Fluorine-Induced Highly Reproducible Resistive Switching Performance: Facile Morphology Control through the Transition between J- and H‑Aggregation

Improving the reproducibility and air-endurance of organic resistance switching (RS) devices, in particular multilevel-cell RS devices, is critical for the confirmation of its competency to realize big data storage capability. However, such enhancement still remains challenging. In this report, we demonstrated that fluorine (F)-embedding should be an effective way to enhance the overall performance of RS devices. Four new azo-cored analogues (IDAZO, FIDAZO, F₂IDAZO, and F₄IDAZO) have been designed and synthesized. These four compounds have similar structures with different numbers of F substituents. Interestingly, UV–vis measurements reveal that upon F-embedding, an exceptional transition from molecular J-aggregation to H-aggregation is achieved. As a result, the morphology of RS films becomes more and more uniform, as determined by AFM and XRD. Meanwhile, the hydrophobicity of RS film is promoted, which further improves the device atmospheric stability. The total RS reproducibility increases to 96% (the uppermost value), and the tristage RS reproducibility rises to 64%, accompanied by a more stable OFF state and lower logic SET voltages. Our study suggests F-embedding would be a promising strategy to achieve highly reproducible and air-endurable organic multilevel-cell RS devices

Boletín de Segovia: Número 84 - 1875 julio 7

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 200

Additional file 1 of Molecular characterization of extensively drug-resistant hypervirulent Pseudomonas aeruginosa isolates in China

Supplementary Material 1: Figure S1. Heatmap of XDR-hvPA carrying resistance genes; Figure S2. Heatmap of XDR-hvPA carrying virulence gene

Precision Synthesis of Sub‑3 nm Bimetallic Alloy Nanoparticles for Efficient and Selective Catalytic Hydrogenolysis of 5‑Hydroxymethylfurfural to 2,5-Dimethylfuran

Miniaturizing bimetallic alloy nanoparticles to sizes below the 3 nm threshold holds great potential to achieve distinct catalytic properties compared to single atoms and larger nanoparticles. However, conventional synthesis methods, including impregnation and nanocluster chemistry, often yield ultrasmall alloy nanoparticles with widely varied sizes or compositions. Herein, we introduce a thermodynamically driven mechanism for the precision synthesis of ultrasmall bimetallic alloy nanoparticles. Metal precursors are uniformly distributed into nanoscale compartments within a microemulsion at equilibrium. After solidifying these nanocompartments, stoichiometric metal alloying is achieved at elevated temperatures. Consequently, homogeneously alloyed bimetallic nanoparticles are synthesized within the sub-3 nm region with high precision in both size and composition. The precision synthesis enables the exploration of size- or composition-dependent catalytic properties. Notably, 1.2 nm-Pt3Co alloy nanoparticles exhibited optimal performance, outperforming other sizes (0.7–3.2 nm) and reported catalysts in the chemoselective hydrogenolysis of 5-hydroxymethylfurfural to 2,5-dimethylfuran, achieving a turnover frequency of 9733 h–1 with ∼100% selectivity. This synthesis unlocks a realm of sub-3 nm bimetallic alloy catalysts with precisely designable properties, holding significant promise for various catalytic processes

DataSheet_1_Detection of somatic copy number deletion of the CDKN2A gene by quantitative multiplex PCR for clinical practice.zip

BackgroundA feasible method to detect somatic copy number deletion (SCND) of genes is still absent to date.MethodsInterstitial base-resolution deletion/fusion coordinates for CDKN2A were extracted from published articles and our whole genome sequencing (WGS) datasets. The copy number of the CDKN2A gene was measured with a quantitative multiplex PCR assay P16-Light and confirmed with whole genome sequencing (WGS).ResultsEstimated common deletion regions (CDRs) were observed in many tumor suppressor genes, such as ATM, CDKN2A, FAT1, miR31HG, PTEN, and RB1, in the SNP array-based COSMIC datasets. A 5.1 kb base-resolution CDR could be identified in >90% of cancer samples with CDKN2A deletion by sequencing. The CDKN2A CDR covers exon-2, which is essential for P16INK4A and P14ARF synthesis. Using the true CDKN2A CDR as a PCR target, a quantitative multiplex PCR assay P16-Light was programmed to detect CDKN2A gene copy number. P16-Light was further confirmed with WGS as the gold standard among cancer tissue samples from 139 patients.ConclusionThe 5.1 kb CDKN2A CDR was found in >90% of cancers containing CDKN2A deletion. The CDKN2A CDR was used as a potential target for developing the P16-Light assay to detect CDKN2A SCND and amplification for routine clinical practices.</p

DataSheet_2_Detection of somatic copy number deletion of the CDKN2A gene by quantitative multiplex PCR for clinical practice.pdf

BackgroundA feasible method to detect somatic copy number deletion (SCND) of genes is still absent to date.MethodsInterstitial base-resolution deletion/fusion coordinates for CDKN2A were extracted from published articles and our whole genome sequencing (WGS) datasets. The copy number of the CDKN2A gene was measured with a quantitative multiplex PCR assay P16-Light and confirmed with whole genome sequencing (WGS).ResultsEstimated common deletion regions (CDRs) were observed in many tumor suppressor genes, such as ATM, CDKN2A, FAT1, miR31HG, PTEN, and RB1, in the SNP array-based COSMIC datasets. A 5.1 kb base-resolution CDR could be identified in >90% of cancer samples with CDKN2A deletion by sequencing. The CDKN2A CDR covers exon-2, which is essential for P16INK4A and P14ARF synthesis. Using the true CDKN2A CDR as a PCR target, a quantitative multiplex PCR assay P16-Light was programmed to detect CDKN2A gene copy number. P16-Light was further confirmed with WGS as the gold standard among cancer tissue samples from 139 patients.ConclusionThe 5.1 kb CDKN2A CDR was found in >90% of cancers containing CDKN2A deletion. The CDKN2A CDR was used as a potential target for developing the P16-Light assay to detect CDKN2A SCND and amplification for routine clinical practices.</p

Additional file 1 of Impact of cell wall polysaccharide modifications on the performance of Pichia pastoris: novel mutants with enhanced fitness and functionality for bioproduction applications

Supplementary Material

Mass Transport Mechanism of Cu Species at the Metal/Dielectric Interfaces with a Graphene Barrier

The interface between the metal and dielectric is an indispensable part in various electronic devices. The migration of metallic species into the dielectric can adversely affect the reliability of the insulating dielectric and can also form a functional solid-state electrolyte device. In this work, we insert graphene between Cu and SiO₂ as a barrier layer and investigate the mass transport mechanism of Cu species through the graphene barrier using density functional theory calculations, second-ion mass spectroscopy (SIMS), capacitance–voltage measurement, and cyclic voltammetry. Our theoretical calculations suggest that the major migration path for Cu species to penetrate through the multiple-layered graphene is the overlapped defects larger than 0.25 nm². The depth-profile SIMS characterizations indicate that the “critical” thickness of the graphene barrier for completely blocking the Cu migration is 5 times smaller than that of the conventional TaN barrier. Capacitance–voltage and cyclic voltammetry measurement reveal that the electrochemical reactions at the Cu/SiO₂ interface become a rate-limiting factor during the bias-temperature stressing process with the use of a graphene barrier. These studies provide a distinct roadmap for designing controllable mass transport in solid-state electrolyte devices with the use of a graphene barrier