Quaternary amines exert anti-myocardial ischemia effects via regulation of energy metabolism and oxygen free radicals in myocardial cells in acute myocardial infarction rats

Purpose: To investigate the effect of quaternary amines on myocardial cells of a rat model of cardiac arrest, with respect to energy generation potential and oxygen free radicals. Methods: Forty-five Sprague-Dawley (SD) rats were assigned to sham, model and quaternary amine groups (each with 15 rats). After their corresponding treatments, lectrocardiogram (ECG) monitoring of the rats in the three groups at various time periods was carried out. Serum levels of myocardial enzymes, thromboxane B2 (TXB2), prostacyclin I2 (PGI2), serum carbon monoxide (CO), and changes in endothelial carbon monoxide synthase (eNOS) and endothelin (ET), were determined. Results: The levels of NO and eNOS were significantly reduced in model rats, relative to sham operation rats, while ET was significantly elevated in sham rats (p < 0.05). There were higher levels of NO and eNOS in the quaternary amine group than in model rats, but ET was higher in quaternary amine group than in model rats. Thromboxane B2 (TXB2) concentration was higher in model rats than in sham rats (p < 0.05). While PGI2 was markedly lower in quaternary group than in sham operation rats. TXB2 was lower in the quaternary amine group than in model rats, while PGI2 was significantly higher in quaternary amine group, relative to model rats (p < 0.05). Conclusion: Quaternary amines exert anti-myocardial effects by regulating energy metabolism and oxygen free radicals in myocardial cells of congestive heart failure rats, and thus are potentially useful for the management of acute myocardial infarction. Keywords: Quaternary amine; Acute myocardial infarction; Electrocardiogram; Serum myocardial enzymes; Myocardial cell

Danshensu exerts cardioprotective effects in rats with acute myocardial infarction via reduction of infiltration of inflammatory cells and mitigation of myocardial fibrosis

Purpose: To investigate the mitigative impact of danshensu on heart tissues in acute myocardial infarction (AMI) rats, and the mechanism of action involved. Methods: Seventy-five male Sprague-Dawley (SD) rats were used in this study. After successful induction of myocardial infarction, the rats were divided into model group (MG), low-dose danshensu group (LDG; 15 mg/kg), middle-dose danshensu group (MDG; 30 mg/kg), and high-dose danshensu group (HDG; 60 mg/kg), with 15 rats per group. Rats in sham group (SG; n = 15) served as control. Serum levels of biochemical indicators and expressions of various proteins in myocardial tissue were determined using Western blotting, and compared amongst the rat groups. Results: Serum cTnI concentrations in MDG and HDG were significantly decreased, relative to the corresponding concentrations in MDG. There were significantly lower serum concentrations of IL-1 in MDG and HDG than in model rats. Rats in HDG had lower serum IL-6 concentration than MG rats, while TNF-α levels were down-regulated in MDG and HDG, relative to MG (p < 0.05). Conclusion: Danshensu protects the heart function of rats with AMI by decreasing inflammationderived cells and mitigating myocardial fibrosis. Thus, it may be useful in the management of AMI in humans but clinical trials are necessary to ascertain this. Keywords: Danshens; Acute myocardial infarction; Myocardial ischemia-reperfusion; Myocardial fibrosi

Holographic Mutual Information of Two Disjoint Spheres

We study quantum corrections to holographic mutual information for two disjoint spheres at a large separation by using the operator product expansion of the twist field. In the large separation limit, the holographic mutual information is vanishing at the semiclassical order, but receive quantum corrections from the fluctuations. We show that the leading contributions from the quantum fluctuations take universal forms as suggested from the boundary CFT. We find the universal behavior for the scalar, the vector, the tensor and the fermionic fields by treating these fields as free fields propagating in the fixed background and by using the 1/n prescription. In particular, for the fields with gauge symmetries, including the massless vector boson and massless graviton, we find that the gauge parts in the propagators play indispensable role in reading the leading order corrections to the bulk mutual information.Comment: 37 pages, 1 figure; significant revisions, corrected the discussions on the computations of the mutual information in CFT, conclusions unchange

Asymptotics for kk-crank of kk-colored partitions

In this paper, we obtain asymptotic formulas for $k$-crank of $k$-colored partitions. Let $M_k(a, c; n)$ denote the number of $k$-colored partitions of $n$ with a $k$-crank congruent to $a$ mod $c$. For the cases $k=2,3,4$, Fu and Tang derived several inequality relations for $M_k(a, c; n)$ using generating functions. We employ the Hardy-Ramanujan Circle Method to extend the results of Fu and Tang. Furthermore, additional inequality relations for $M_k(a, c; n)$ have been established, such as logarithmic concavity and logarithmic subadditivity.Comment: 40 pages. arXiv admin note: text overlap with arXiv:1311.4344 by other author

Determinant representations for scalar products of the XXZ Gaudin model with general boundary terms

We obtain the determinant representations of the scalar products for the XXZ Gaudin model with generic non-diagonal boundary terms.Comment: Latex file, 17 page

Bis[2-(2-pyridylmethyl­amino)ethane­sulfonato-κ3 N,N′,O]zinc(II)

The title mononuclear complex, [Zn(C8H11N2O3S)2], is a zinc salt of 2-(2-pyridylmethyl­amino)ethane­sulfonic acid (Hpmt). The ZnII ion is located on an inversion centre and is octahedrally surrounded by four N and two O atoms. The deprotonated pmt− anion coordinates in a facial arrangement through its two N atoms and one of the sulfonate O atoms. The crystal packing is determined by inter­molecular N—H⋯O and C—H⋯O hydrogen bonds