A nodule on the forearm

Glomus tumors are benign tumors of the skin. Clinically, these tumors can present as solid, painful subcutaneous nodules, frequently seen on the hand (particularly subungual region). Glomangiomyomas are the least common histological type of glomus tumor. In the literature, there are only a few glomangiomyoma cases of the forearm location. We report a patient with a painful nodule, diagnosed as glomangiomyoma. Surgical excision was performed and no recurrence was observed after 5 years' follow-up

INFORMATION SYSTEM STRATEGY PLANNING RELAT-ED TO SEAM: A CASE STUDY OF EA AND DIGITAL TRANSFORMATION COMBINATION

Inconsistency always occurs between digital transformation (DT) strategy and information system（IS）and enterprise architecture (EA) planning. This symptom leads to repeated investment, de-lay, or failure in DT projects. In addition, it will create leakages in DT value. Moreover, in the dy-namic digital environment, the inconsistency of between DT strategy and EA planning process is exacerbated due to dynamic business strategies. This paper applies SEAM and BPM theories to explore the scenario method for applying EA to DT strategies operation to explain inconsistent strategic planning symptoms and outline the DT-EA strategy planning integration process frame-work. The research method of this paper is multiple case studies, and the data collection sources include semi-structured interviews of 106 interviewees, material collection, literature comparison, and observation. By comparing four critical cases, this research shows the relationship between DT and EA and reveals the dysfunction in DT strategic implementation from the SEAM and BPM perspective. In practice, this research integrates DT and EA to provide a context method for enter-prise DT strategy planning design

BPM OR CPM？A CASE STUDY OF CROSS-DEPARTMENT COMMUNICATION BUSINESS OPERATION AND HIDDEN COST RELATED TO AMBIDEXTERITY PERFORMANCE

Business process management (BPM) as a mature business operation management method has been applied by many enterprises. Its main concerns focus on solving the cross departmental communication problems. Cross-department communication is a visible symptom of the growing business problems of companies related to complexity，it is also a problem strongly related to BPM. These barriers will lead to low efficiency and poor-quality work, which is common in most organizations in China. This will bring hidden costs to the organization and even impact long-term performance. In the digital transformation age, organization ambidexterity is more important than ever to obtain short-term and long-term benefits. This case study suggests to combine the ambidextrous and hidden costs theory for outlining a collaborative network communication model (CNCM) and theory relationship model of hidden costs and ambidexterity BPM, in order to inves-tigate the effect between the cross-department communication operation structure and organiza-tional performance. This case study provided data collection by three data sources: 40 interviews of managers and employees, company records，observations over 3 months. The findings of the field study of this case are that cross-department communication operation structure has an effect on organizational performance and digital innovation. It also suggests that CNCM positively influences organizational exploration and exploitation ability. It can also alleviate cross-department communication obstacles, low efficiency, and poor-quality work

Genetically encoded biosensor for engineering branched-chain higher alcohol production pathway in saccharomyces cerevisiae

Branched-chain higher alcohols (BCHAs) including isobutanol, isopentanol, and 2-methyl-1-butanol, are promising alternatives to the first-generation biofuel ethanol. These alcohols have better fuel properties than ethanol, such as higher energy density, ease of refining, and better compatibility with existing gasoline engines and infrastructures 1. We have developed a genetically encoded biosensor to measure the metabolic activity of BCHA biosynthesis in Saccharomyces cerevisiae. This biosensor enables high-throughput screens to identify strains with higher metabolic flux to BCHA synthesis. The versatility of this tool has allowed us to use it in several applications, including in vivo BCHA metabolic pathway engineering/optimization and enzyme engineering. We have been able to screen for isobutanol hyper-producing stains with optimum combinations of genes from the mitochondrial isobutanol pathway (Mito-IbOH-pathway) 2. The ability of this biosensor to monitor the activity of both the mitochondrial 2 and cytosolic isobutanol pathways 3, has allowed us to engineer several enzymes and regulatory proteins involved in the isobutanol pathways in either compartment, boosting enzymatic activity by as much as 400%. Thus, we have demonstrated the use of this new technology to accelerate the development of strains and enzymes to boost BCHA production in mitochondria and the cytosol. Future applications include combining the biosensor with optogenetic regulation of BCHA biosynthesis for closed-loop dynamic control of this pathway, and using the biosensor to empower systems biology studies for gene discovery, enzyme evolving, and enzyme engineering to boost BCHA production. Please click Additional Files below to see the full abstract