Ion Beam-Treated Space Polymers: Long-Term Stability in GEO-Simulated Environments

As part of a large program conducted between years 2010 and 2018, a number of ion beam surface treatments and proprietary coatings formed on advanced space polymers by direct ion beam deposition were developed at Integrity Testing Laboratory (ITL) Inc, in Canada. Thistechnology allowed producing surfaces with controlled surface resistivity in a wide range of charge dissipation values, with negligibly low additional RF losses and other important functional properties, that allowed using such treated materials and products in modern space antennae, solar arrays and other external applications on spacecrafts in GEO environment. This paper will present an overview of results achieved throughout the years on enhancement of radiation stability of space polymers that were ion beam treated and coated with special multifunctional thin coatings by direct ion beam deposition. The treated/coated subjects have been ground-based tested in a range of radiation conditions, simulating the GEO radiation environment, conducted in three world-recognized GEO simulation facilities

Downstream fining in a megaclast-dominated fluvial system: the Sabeto River of western Viti Levu, Fiji

Megaclast-dominated fluvial systems have been largely ignored by researchers. Yet megaclasts exert an important control on channel geomorphology, flow behaviour and sediment transport, and such systems are probably far more common than this neglect would suggest. Despite the explicit identification of megaclasts as the products of cataclysmic flow, observation of modern fluvial systems confirms that megaclasts can be entrained by flows that lie within the normal flow regime. The pattern of fining along the megaclast-dominated Sabeto River of western Viti Levu, Fiji reveals a strong negative exponential relationship between particle size and distance downstream, and a rate of downstream fining comparable with that of other gravel-bed rivers. The downstream fining pattern is straightforward and step-like discontinuities in the fining gradient are absent. This is suggestive of a sedimentary system only minimally disrupted by the supply of sediment from tributaries or the reworking of material from sources such as hillslopes and alluvial terraces. There is evidence, however, of anomalously coarse sub-populations at two sites. These coarser components must pre-date the other deposits at the sites. We speculate that they represent the products of earlier and higher-magnitude events. The bed sediments may thus be composite features, made up of individual components each transported by a specific event of particular magnitude. Our work confirms the relationship between the rate of downstream fining and particle size. This may arise because the distance over which individual particles are transported is likely to be size dependent. It is also possible that abrasion may be more effective in the case of larger particles than smaller ones, with the result that the coarser fraction of the river's bed sediment fines downstream more rapidly than the finer fraction. There is a long-standing debate about the relative roles of abrasion and sorting in downstream fining. Our data reveal little evidence for a downstream increase in the roundness of the river's gravels, implying that abrasion is likely to play a minor role in the fining process in this system

Firefly distribution and abundance on mangrove vegetation assemblages in Sepetang estuary, Peninsular Malaysia

Pteroptyx fireflies are commonly reported to congregate in large numbers in mangroves. Not much is known about the relationships between firefly distribution and abundance with specific mangrove vegetation assemblages. We conducted a study to investigate the vegetation assemblages that structure the distribution and abundance of Pteroptyx tener in Peninsular Malaysia. The distribution and abundance of fireflies were assessed along an 8 km stretch of mangroves in Sepetang estuary using visual assessment. Statistical analysis was carried out to test the correlation between length of display section and percentage cover of P. tener colonies and the relationship between percentage cover of fireflies with different vegetation assemblages. Five distinct vegetation assemblages were identified comprising different combination of four mangrove species. It was found that shorter display sections had higher percentage cover of P. tener colonies. In addition, vegetation assemblage which consisting of mainly Sonneratia caseolaris and Nypa fruticans was the most preferred type. The results of this study point to the necessity to consider not only a single mangrove species but the entire vegetation assemblage for firefly conservation

A requirement for filopodia extension toward Slit during Robo-mediated axon repulsion

Axons navigate long distances through complex 3D environments to interconnect the nervous system during development. Although the precise spatiotemporal effects of most axon guidance cues remain poorly characterized, a prevailing model posits that attractive guidance cues stimulate actin polymerization in neuronal growth cones whereas repulsive cues induce actin disassembly. Contrary to this model, we find that the repulsive guidance cue Slit stimulates the formation and elongation of actin-based filopodia from mouse dorsal root ganglion growth cones. Surprisingly, filopodia form and elongate toward sources of Slit, a response that we find is required for subsequent axonal repulsion away from Slit. Mechanistically, Slit evokes changes in filopodium dynamics by increasing direct binding of its receptor, Robo, to members of the actin-regulatory Ena/VASP family. Perturbing filopodium dynamics pharmacologically or genetically disrupts Slit-mediated repulsion and produces severe axon guidance defects in vivo. Thus, Slit locally stimulates directional filopodial extension, a process that is required for subsequent axonal repulsion downstream of the Robo receptor.National Institutes of Health (U.S.) (Grant F32-CA165700)National Institutes of Health (U.S.) (Grant R01-GM068678)National Institutes of Health (U.S.) (Grant P30-CA014051

NrCAM, a neuronal system cell-adhesion molecule, is induced in papillary thyroid carcinomas

NrCAM (neuron-glia-related cell-adhesion molecule) is primarily, although not solely, expressed in the nervous system. In the present study, NrCAM expression was analysed in a series (46) of papillary thyroid carcinomas (PTCs) and paired normal tissues (NT). Quantitative reverse transcriptase (QRT)-PCR revealed that NrCAM expression was upregulated in all PTCs compared to normal thyroid, whatever the stage or size of the primary tumour. NrCAM transcript levels were 1.3- to 30.7-fold higher in PTCs than in NT. Immunohistochemistry (IHC) confirmed that the expression of NrCAM was considerably higher in tumours (score 2+/3+) than in adjacent normal paratumoural thyroid tissue. The NrCAM protein was detected in all but three (93.3%) PTC samples, and it was mainly cytoplasmic; in some cases there was additional membranous localisation – basolateral and partly apical. In the normal thyroid and tissues surrounding tumours, focal NrCAM immunolabelling was seen only in follicles containing tall cells, where staining was restricted to the apical pole of thyrocytes. Western blot analysis corroborated the QRT–PCR and IHC results, showing higher NrCAM protein levels in PTCs than in paired NT. The level of overexpression of the NrCAM mRNA in tumourous tissue appeared to be independent of the primary tumour stage (pT) or the size of the PTC. These data provide the first evidence that NrCAM is overexpressed in human PTCs at the mRNA and protein levels, whatever the tumour stage. Thus, the induction and upregulation of NrCAM expression could be implicated in the pathogenesis and behaviour of papillary thyroid cancers